Volume 7.48 | Dec 18

Immune Regulation News 7.48 December 18, 2015
Immune Regulation News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
Like Us on Facebook   IRN on Twitter
 
TOP STORY
Polysialylation Controls Dendritic Cell Trafficking by Regulating Chemokine Recognition
Researchers showed that CCR7, the central chemokine receptor controlling immune cell trafficking to secondary lymphatic organs, carries polysialic acid. As a consequence, dendritic cell trafficking is abrogated in polysialyltransferase deficient mice, manifesting in disturbed lymph node homeostasis and unresponsiveness to inflammatory stimuli. [Science] Abstract
Perform automated cell isolation from up to 16 samples at once with RoboSep™-16.
 
PUBLICATIONS (Ranked by impact factor of the journal)
Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells
Using a mouse model of PTEN-deficient uterine cancer, scientists describe a surprising inhibitory role for polymorphonuclear neutrophils (PMNs) in epithelial carcinogenesis. By inducing tumor cell detachment from the basement membrane, PMNs impeded early-stage tumor growth and retarded malignant progression. [Cancer Cell] Abstract | Graphical Abstract

T-Box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate
Researchers showed that CD8+CD103+ tissue-resident memory T cells, independent of circulating memory T cells, were sufficient for protection against infection and described molecular elements that were crucial for their development in skin and lung. [Immunity] Abstract

Oligodendrocyte Death Results in Immune-Mediated CNS Demyelination
To investigate whether oligodendrocyte death could cause this autoimmune response, investigators examined the oligodendrocyte ablation Plp1-CreERT;ROSA26-eGFP-DTA mouse model. Late-onset disease was associated with increased numbers of T lymphocytes in the CNS and myelin oligodendrocyte glycoprotein-specific T cells in lymphoid organs. [Nat Neurosci] Abstract | Press Release

AKAP9 Regulates Activation-Induced Retention of T Lymphocytes at Sites of Inflammation
Researchers generated mice with a T cell-specific deletion of the scaffold protein A kinase anchoring protein 9 (AKAP9) and use models of inflammatory disease to demonstrate that AKAP9 is dispensable for T cell priming and migration into tissues and lymph nodes, but is required for T cell retention in tissues. [Nat Commun] Full Article

T Cell Intrinsic USP15 Deficiency Promotes Excessive IFN-γ Production and an Immunosuppressive Tumor Microenvironment in MCA-Induced Fibrosarcoma
Investigators found that the USP15-deficient mice are hypersensitive to methylcholantrene (MCA)-induced fibrosarcomas. Excessive IFN-γ production in USP15-deficient mice promotes expression of the immunosuppressive molecule PD-L1 and the chemokine CXCL12, causing accumulation of T-bet+ regulatory T cells and CD11b+Gr-1+ myeloid-derived suppressor cells at tumor site. [Cell Rep]
Full Article | Graphical Abstract

Transpresentation of Interleukin-15 by IL-15/IL-15Rα mRNA-Engineered Human Dendritic Cells Boosts Antitumoral Natural Killer Cell Activity
Investigators engineered monocyte-derived dendritic cells to produce interleukin (IL)-15 and/or IL-15 receptor alpha (IL-15Rα) using mRNA electroporation. The addition of IL-15Rα to the protocol, enabling IL-15 transpresentation to neighboring natural killer (NK) cells, resulted in significantly better NK-cell activation compared to IL-15 alone. [Oncotarget] Full Article

Suppression of Established Hepatocarcinoma in Adjuvant Only Immunotherapy: Alum Triggers Anti-Tumor CD8+ T Cell Response
The authors report that injection of alum, the most widely used human adjuvant, into mice carrying H22 hepatocarcinoma resulted in a significant reduction of tumor growth with extended animal survival. This effect was associated with an increased specific CD8+ T cell activation and an inflammatory environment, yet with minimal overt side effects. [Sci Rep] Full Article

Accumulation Mechanisms of CD4+CD25+FOXP3+ Regulatory T Cells in EBV-Associated Gastric Carcinoma
Because regulatory T cells (Tregs) are regarded as a critical hurdle in anti-tumour immunity, the authors assessed the distribution of Tregs in 45 cases of Epstein-Barr virus (EBV)-associated gastric carcinomas (EBVaGCs) and 45 cases of EBV-negative gastric carcinoma (EBVnGC) with matched clinicopathological parameters by immunohistochemistry. They showed that Tregs were significantly increased in EBVaGC compared to EBVnGC. [Sci Rep] Full Article

Don’t forget to subscribe to Human Immunology News and Immunology of Infectious Disease News!

Isolate particle-free human CD4+CD127lowCD25+ regulatory T cells (Tregs) in less than one hour. Request a sample today.
 
REVIEWS
Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions
The authors compare and contrast the effects of human genetic mutations of and therapeutic interventions targeted at T helper 17 (Th17) cell molecules. They discuss that although there are similarities when Th17 cell pathway molecules are modulated, each molecule has unique non-Th17 cell features that lead to different functional outcomes. [Immunity] Abstract

Visit our reviews page to see a complete list of reviews in the immune regulation research field.
 
INDUSTRY NEWS
NewLink Genetics Corporation Completes Enrollment of Phase III PILLAR Trial Evaluating Algenpantucel-L for Patients with Locally Advanced Pancreatic Cancer
NewLink Genetics Corporation announced the completion of enrollment in the Phase III PILLAR (Pancreatic Immunotherapy with algenpantucel-L for Locally Advanced non-Resectable cancer) clinical trial of algenpantucel-L for patients with borderline resectable or locally advanced unresectable pancreatic cancer. [NewLink Genetics Corporation] Press Release

Treatment of Lupus : Lupuzor™ Enters Phase III
Lupuzor™ may become the first specific and non-immunosuppressant therapy for lupus, a disabling autoimmune disease that is currently incurable. This peptide is the subject of a CNRS patent and has already successfully completed Phases I and II of its regulatory clinical trials. [CNRS] Press Release

Neovacs Signs a Strategic Partnering Agreement with the Korean Company CKD Pharmaceutical Corp.
NEOVACS announced the signature of an exclusive licensing agreement with Chong Kun Dang (CKD) Pharmaceutical Corp. to market the IFNα-Kinoïd for the indications of lupus and dermatomyositis, in South Korea. [Neovacs SA] Press Release

From our sponsor: Learn how to isolate cells from whole blood in 25 minutes. Watch the video.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Advances in Immuno-Oncology Congress 2016
May 12-13, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the immune regulation community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Immunology (VIB)

NEW PhD Position – Immunology (VIB)

NEW Postdoctoral Research Fellow – Immunity (Massachusetts General Hospital & Harvard Medical School)

Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Position – Immunotherapy Targeting Cancer Stem Cells (Ecole Polytechnique Fédérale de Lausanne)

Postdoctoral Position – Cancer Immunotherapy (Bayer HealthCare AG)

Researchers – Immunotherapy (ISPIC Consortium Members)

Associate Professor – Immuno-Engineering (University of Chicago)

Research Technician – Preclinical and Translational Research (Qu Biologics Inc.)

Postdoctoral Fellow – Regulatory Functions of Immune-Checkpoint Proteins (Medical College of Wisconsin)


Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
 

Have we missed an important article or publication in Immune Regulation News? Click here to submit!

Comments or suggestions? Submit your feedback here
Learn more about Immune Regulation News: Archives | Events | Contact Us