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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
Functional CRISPR Screens in T Cells Reveal New Opportunities for Cancer Immunotherapies
[Molecular Cancer] Investigators bridge the gap between discovering element genes to a specific process of T cell activities and apprehending these genes in the global T cell life cycle, deepened the understanding of T cell biology in tumour immunity, and outline CRISPR screens resources that might facilitate the development and implementation of cancer immunotherapies in the clinic.
Tertiary Lymphoid Structural Heterogeneity Determines Tumour Immunity and Prospects for Clinical Application
[Molecular Cancer] The authors explore the dynamic interactions among T and B cell subpopulations of varying phenotypes that contribute to the structural and functional diversity of TLS, examining both existing and emerging techniques for TLS imaging and induction, focusing on cancer immunotherapies and biomaterials.
Immunogenic Material Vaccine for Cancer Immunotherapy by Structure-Dependent Immune Cell Trafficking and Modulation
[Advanced Materials] Scientists manipulated the immunopotentiator manganese into six differing structures that resemble the architectures of two types of pathogens. They revealed that innate immune cells accurately sense and respond to the architectures, of which two outperformed material candidates showedhigher competence in creating local pro-inflammatory environment with promoted innate immune cell influx and stimulatory effects on multiple subsets of dendritic cells.
Tumor-Targeted Therapy with BRAF-Inhibitor Recruits Activated Dendritic Cells to Promote Tumor Immunity in Melanoma
[Journal For Immunotherapy Of Cancer] Scientists investigated therapy-mediated immunological alterations in the tumor microenvironment and tumor-draining lymph nodes in the D4M.3A preclinical melanoma mouse model by using high-dimensional multicolor flow cytometry in combination with multiplex immunohistochemistry.
Organoids as a Tool to Study Homeostatic and Pathological Immune–Epithelial Interactions in the Gut
[Clinical & Experimental Immunology] Researchers provided an overview of how intestinal organoids are being co-cultured with immune cells leading to substantial advances in our understanding of immune–epithelial interactions in the gut.
Spatial Distribution of Tumor-Associated Macrophages in an Orthotopic Prostate Cancer Mouse Model
[Pathology and Oncology Research] Researchers examined the spatial-temporal dynamics of three different immune cell types infiltrating tumors using QuPath image analysis software. Immunohistochemistry staining revealed that F4/80+ tumor-associated macrophages were the most abundant immune cells in all groups, irrespective of time or treatment.
Respiratory Complex I Regulates Dendritic Cell Maturation in Explant Model of Human Tumor Immune Microenvironment
[Journal For Immunotherapy Of Cancer] Scientists established a patient-derived explant culture model of breast cancer, which retained the immune contexture of the primary tumor, recapitulating cytokine profiles and CD8+ T cell cytotoxic activity.
Surface-Functionalized Microgels as Artificial Antigen-Presenting Cells to Regulate Expansion of T Cells
[Advanced Materials] Investigators showed that microgels with tailored surface biochemical properties can serve as aAPCs to mediate T cell activation and expansion.
Blockade of TGF-β and PD-L1 by Bintrafusp Alfa Promotes Survival in Preclinical Ovarian Cancer Models by Promoting T Effector and NK Cell Responses
[British Journal Of Cancer] The authors tested whether coordinated blockade of TGF-β and PD-L1 with bintrafusp alfa could provoke anti-tumour immune responses in preclinical high-grade serous ovarian cancer models.
CCR5 and Inflammatory Storm
[Ageing Research Reviews] Scientists illuminate the regulatory axes modulating signaling pathways in inflammatory cells by providing a comprehensive overview of the pathogenic processes associated with CCR5 and its ligands across various disorders.
Long COVID Linked to Signs of Ongoing Inflammatory Responses in Blood
[New Scientist] People with long-COVID after a serious COVID-19 infection have raised levels of many immune molecules in their blood. Better understanding how these molecules can vary could lead to more targeted treatments
Evolution of T Cells in the Cancer-Resistant Naked Mole-Rat
[Nature Communications] Using single-cell transcriptomics, researchers found that that naked mole rats had a large circulating population of γδT cells, which in mice and humans mostly reside in peripheral tissues and induce anti-cancer cytotoxicity.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
