Volume 12.24 | Jul 3

2020-07-03 | IRN 12.24
Immune Regulation News by STEMCELL Technologies
Vol. 12.24 – 3 July, 2020

Structural Cells Are Key Regulators of Organ-Specific Immune Responses

To advance our understanding of immunology outside the hematopoietic system, researchers systematically investigate the regulation of immune genes in the three major types of structural cells: epithelium, endothelium and fibroblasts.

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Chd4 Choreographs Self-Antigen Expression for Central Immune Tolerance

Scientists found that the chromatin remodeler Chd4, also called Mi-2β, played a key role in the self-antigen expression in medullary thymic epithelial cells.
[Nature Immunology]


Sex Differences in Neutrophil Biology Modulate Response to Type I Interferons and Immunometabolism

The authors showed that Rab44 was highly expressed in bone marrow cells among various mouse tissues.
[Proceedings of the National Academy of Sciences of the United States of America]


Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy

Researchers established an apoptosis inhibitor of macrophage (AIM)-deficient IgAN model using CRISPR/Cas9 and compared its phenotype with that of wild-type gddY with or without recombinant AIM administration. An IgA-deficient IgAN model was also generated to further determine the role of AIM.
[Journal of the American Society of Nephrology]


MCL-1 Is Essential for Survival but Dispensable for Metabolic Fitness of FOXP3+ Regulatory T Cells

Investigators elucidated the relative importance of these distinct biological functions of MCL-1 in T regulatory cells to assess whether MCL-1 inhibition might impact upon the metabolism of cells able to resist apoptosis.
[Cell Death & Differentiation]


PD-L1+ Exosomes from Bone Marrow-Derived Cells of Tumor-Bearing Mice Inhibit Antitumor Immunity

Researchers report that exosomes from bone marrow-derived cells in tumor-bearing mice, but not in healthy mice, carried PD-L1. PD-L1 on these exosomes was biofunctional and could inhibit CD8+ T cell proliferation and activation in vitro and in vivo.
[Cellular & Molecular Immunology]


Expression and Localisation of Rab44 in Immune-Related Cells Change during Cell Differentiation and Stimulation

Investigators performed RNA sequencing on circulating neutrophils from healthy adult females and males. Female neutrophils displayed significant up-regulation of type I IFN-stimulated genes.
[Scientific Reports]

Full Article

Extracellular Glucose Is Crucially Involved in the Fate Decision of LPS-Stimulated RAW264.7 Murine Macrophage Cells

The authors showed that lipopolysaccharide (LPS) stimulation of RAW264.7 murine macrophage celled results in pyroptosis when cells were cultured in high glucose medium.
[Scientific Reports]

Full Article

Learn about immunological considerations for hPSC banking by watching Dr. David Turner's webinar from the Nature Research Round Table on hPSC Quality

ACOD1 in Immunometabolism and Disease

Mechanistically, several immune receptors, adapter proteins, ubiquitin ligases, and transcription factors formed complex signal transduction networks to control ACOD1 expression in a context-dependent manner.
[Cellular & Molecular Immunology]



United Kingdom Plans ‘Office for Talent’ to Smooth Entry for Top Scientists

The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.


Hong Kong Universities Rattled by New Security Law

Academics in Hong Kong are facing new worries after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom.


Amidst Uncertainty, Flexibility Is Key in Higher Ed, Faculty Say

Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
[The Scientist]



The New York Stem Cell Foundation (NYSCF) Conference

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Postdoctoral Researcher – Microbiome in Chronic Diseases

University of Luxembourg – Luxembourg, Luxembourg

Postdoctoral Researcher – RNA Epitranscriptomics and Immune Cells

Lund University – Lund, Sweden

Research Associate – Cancer Immunology

King’s College London – London, United Kingdom

Professor – Immunology

Lund University – Scania, Sweden

Postdoctoral Researcher – Genetic Engineering of Dendritic Cells

Aarhus University – Aarhus C, Denmark

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