Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

First Pig Kidney Transplant in a Person: What It Means for the Future

[Nature] Early success in the first transplant of a pig kidney into a living person has raised researchers’ hopes for larger clinical trials involving pig organs. Such trials could bring ‘xenotransplantation’, the use of animal organs in human recipients, into the clinic.

The ω-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid Enhances NK-Cell Antitumor Effector Functions

[Cancer Immunology Research] Investigators explored whether docosahexaenoic acid (DHA), a type of ω-3 PUFA, had an immunomodulatory role in promoting tumour growth in immunocompetent mice. The number of natural killer (NK) cells but not the number of T or B cells was decreased by DHA supplementation in various tissues under physiological conditions.

Gene Features of Tumor-Specific T Cells Relevant to Immunotherapy, Targeted Therapy and Chemotherapy in Lung Cancer

[Heliyon] Researchers defined tumor-specific T cells and their features (TSTGs) by single-cell RNA sequencing. They applied LASSO regression to filter out the most survival-relevant TSTGs to form the Tumor-specific T cell score (TSTS). Immunological characteristics, enriched pathways, and mutation were evaluated in high- and low TSTS groups.

Intestinal Tuft Cell Immune Privilege Enables Norovirus Persistence

To examine how tuft cells promote immune escape, investigators interrogated tuft cell interactions with CD8+ T cells by adoptively transferring just EGFP death inducing...

IFN-λ Drives Distinct Lung Immune Landscape Changes and Antiviral Responses in Human Metapneumovirus Infection

[mBio] Scientists showed that type III interferon (IFN-λ) was highly upregulated during human metapneumovirus infection in vitro in human and mouse airway epithelial cells and in vivo in mice. They found through several immunological and molecular assays that type II alveolar cells are the primary producers of IFN-λ.

Metformin Suppresses Both PD-L1 Expression in Cancer Cells and Cancer-Induced PD-1 Expression in Immune Cells to Promote Antitumor Immunity

[Annals Of Laboratory Medicine] Scientists identified the inhibitory molecular mechanisms of metformin on programmed death ligand 1 expression in cancer cells and programmed death 1 expression in immune cells.

Quantification of Adaptive Immune Responses Against Protein Binding Interfaces in the Streptococcal M1 Protein

[Molecular & Cellular Proteomics] Investigators used affinity-purification combined with quantitative mass spectrometry to examine the level of competition between antigen-specific antibodies and host-pathogen protein interaction networks using the M1 protein from Streptococcus pyogenes as a model system.

Regulatory T Cells Subgroups in the Tumor Microenvironment Cannot Be Overlooked: Their Involvement in Prognosis and Treatment Strategy in Melanoma

[Environmental Toxicology] Researchers employed single-cell analysis to unveil the intricate nature of Tregs in human melanoma.

TOLLIP Inhibits Lipid Accumulation and the Integrated Stress Response in Alveolar Macrophages to Control Mycobacterium tuberculosis Infection

[Nature Microbiology] Researchers showed that tuberculosis severity was increased in Tollip−/− mice, characterized by macrophage- and T cell-driven inflammation, foam cell formation, and lipid accumulation.

IKK2 Controls the Inflammatory Potential of Tissue-Resident Regulatory T Cells in a Murine Gain of Function Model

[Nature Communications] Investigators showed that mice heterozygous for an Ikbkb gain-of-function mutation develop psoriasis. Doubling the gene dose results in dactylitis, spondylitis, and characteristic nail changes, which are features of psoriatic arthritis.

Harnessing Innate Immune Pathways for Therapeutic Advancement in Cancer

[Signal Transduction And Targeted Therapy] Scientists observed that the role of the innate immune pathway demonstrated heterogeneity, linked to the tumor development stage, pathway status, and specific cell types. They proposed that within the tumor microenvironment, the innate immune pathway exhibited multidimensional diversity.

Antibody-Suppressor CXCR5+CD8+ T Cells Are More Potent Regulators of Humoral Alloimmunity after Kidney Transplant in Mice Compared to CD4+ Regulatory T Cells

The authors investigated the potency of novel Ab-suppressor CXCR5+CD8+ T cells in comparison with conventional CD25highFoxp3+CD4+ Tregs for suppression of humoral alloimmunity in a...

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.

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