Volume 12.23 | Jun 26

2020-26-06 | IRN 12.23
Immune Regulation News by STEMCELL Technologies
Vol. 12.23 – 26 June, 2020
TOP STORY

Tet2 and Tet3 in B Cells Are Required to Repress CD86 and Prevent Autoimmunity

The authors report that deficiency of ten–eleven translocation (Tet) DNA demethylase family members Tet2 and Tet3 in B cells led to hyperactivation of B and T cells, autoantibody production and lupus-like disease in mice.
[Nature Immunology]

Abstract
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Chemical Genetics Strategy to Profile Kinase Target Engagement Reveals Role of FES in Neutrophil Phagocytosis

Researchers describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.
[Nature Communications]

Full Article

NCX1 Represents an Ionic Na+ Sensing Mechanism in Macrophages

Scientists showed that the Na+/Ca2+ exchanger 1 played a critical role in high salt-triggered Na+ influx, concomitant Ca2+ efflux, and subsequent augmented NFAT5 accumulation.
[PLoS Biology]

Full Article

A Recombinant Protein rLZ-8, Originally Extracted from Ganoderma lucidum, Ameliorates OVA-Induced Lung Inflammation by Regulating Th17/Treg Balance

Investigators examined whether Ling‐Zhi 8 (rLZ‐8) would ameliorate pulmonary inflammation in a model of asthma‐like mice.
[Journal of Leukocyte Biology]

Abstract

Oncolytic Virus-Derived Type I Interferon Restricts CAR T Cell Therapy

Investigators tested whether the inflammatory nature of oncolytic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the functionality of CAR T cells.
[Nature Communications]

Full Article

Switch of Macrophage Fusion Competency by 3D Matrices

Scientists introduced a collagen-based 3D matrix to embed Raw264.7 cell line and primary rat bone marrow-derived macrophages.
[Scientific Reports]

Full Article

Exosomes Released by Breast Cancer Cells under Mild Hyperthermic Stress Possess Immunogenic Potential and Modulate Polarization In Vitro in Macrophages

Cytotoxicity of different hyperthermic temperatures and treatment durations were tested in normal murine macrophages and breast cancer cell lines.
[International Journal of Hyperthermia]

Full Article

Gut Dysbiosis Modulates the Immune Response to Factor VIII in Murine Hemophilia A

Investigators demonstrate that a disrupted gut microbiota could be created in a mouse model of hemophilia A using a broad-spectrum antibiotic.
[Blood Advances]

Full Article Graphical Abstract

PD-L1 Expression by Dendritic Cells Is a Key Regulator of T-Cell Immunity in Cancer

Investigators demonstrated that dendritic cells represented a critical source of PD-L1, despite being vastly outnumbered by PD-L1+ macrophages.
[Nature Cancer]

Abstract

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REVIEWS

The Cancer–Natural Killer Cell Immunity Cycle

Investigators discuss how the role of NK cells evolves with tumor progression, presenting new opportunities to target NK cell function to enhance cancer immunotherapy response rates across a more diverse range of cancers.
[Nature Reviews Cancer]

Abstract

Thymic Development of Unconventional T Cells: How NKT Cells, MAIT Cells and γδ T Cells Emerge

Scientists describe the thymic development of NK T cells, mucosal-associated invariant T (MAIT) cells and γδ T cells and highlight some of the key differences between conventional and unconventional T cell development.
[Nature Reviews Immunology]

Abstract

Immunotherapies and Metastatic Cancers: Understanding Utility and Predictivity of Human Immune Cell Engrafted Mice in Preclinical Drug Development

Pre-clinical immuno-oncology models for studying metastases have long been limited to syngeneic or carcinogenesis-inducible models that have murine cancer and immune cells.
[Cancers]

Full Article

INDUSTRY AND POLICY NEWS

NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]

Editorial

Gender Gap in Research Output Widens during Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]

Editorial

Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]

Editorial

Aduro Biotech Announces First Patient Dosed in Phase I Study of BION-1301 in IgA Nephropathy

Aduro Biotech, Inc. announced that the first patient with IgA nephropathy has been dosed in a Phase I clinical trial of BION-1301, an investigational humanized IgG4 monoclonal antibody that blocks APRIL binding to both the BCMA and TACI receptors.
[Audro Biotech, Inc.]

Press Release

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