Volume 8.01 | Jan 15

Immune Regulation News 8.01 January 15, 2016
Immune Regulation News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation
Scientists showed that after hematopoietic stem cell transplantation, cytotoxic T lymphocytes (CTLs) exhibited different killing activity in distinct tissues, being highest in the liver and lowest in lymph nodes. [Immunity] Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function
Apoptosis inducing factor (Aif)-deficiency in T cells led to decreased peripheral T cell numbers and defective homeostatic proliferation, but thymic T cell development was unaffected. In contrast, Aif-deficient B cells developed and functioned normally. [Immunity] Abstract | Graphical Abstract

Conditioning of Naive CD4+ T Cells for Enhanced Peripheral Foxp3 Induction by Nonspecific Bystander Inflammation
Investigators showed that nonspecific bystander inflammation conditions naive CD4+ T cells for enhanced peripheral Foxp3 induction and reduced effector differentiation. This results in inhibition of immune responses in vivo via a Foxp3-dependent effect on antigen-specific naive CD4+ T cell precursors. [Nat Immunol] Abstract

Enhanced Efferocytosis by Dendritic Cells Underlies Memory T-Cell Expansion and Susceptibility to Autoimmune Disease in CD300f-Deficient Mice
Scientists showed that, in contrast to CD300f function in macrophages, its expression inhibits efferocytosis by DC, and its deficiency leads to enhanced antigen processing and T-cell priming by these DC. [Cell Death Differ] Abstract

TRAIL-Coated Leukocytes that Prevent the Bloodborne Metastasis of Prostate Cancer
Scientists demonstrated an approach using nanoscale liposomes conjugated with E-selectin adhesion protein and Apo2L/TRAIL (TNF-related apoptosis-inducing ligand) apoptosis ligand that attach to the surface of leukocytes and rapidly clear viable cancer cells from circulating blood in the living mouse. [J Control Release] Abstract | Press Release | Video

TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-Pneumococcal Immunity
Researchers found that, in both humans and mice, circulating monocyte phenotype and function was altered with age due to increasing levels of tumor necrosis factor (TNF) in the circulation that occur as part of the aging process. [PLoS Pathog] Full Article | Press Release

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
cGAMP enhances innate immune responses by inducing production of cytokines such as interferon-β, interferon-γ, and stimulating dendritic cells activation, which induces the cross-priming of CD8+ T cells. [Sci Rep] Full Article

Antigen-Specific T Cells Fully Conserve Antitumor Function following Cryopreservation
Scientists showed that cryopreservation fully conserves the differentiation potential of effector T cells, secretion of pro-inflammatory cytokines, cytotoxic function and does not impair the three-dimensional scanning motility of T cells or their capacity to infiltrate and reject tumors. [Immunol Cell Biol] Full Article

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REVIEWS
The Immune System and Cancer Evasion Strategies: Therapeutic Concepts
The authors review the current understanding of cancer immunology in general, including immune surveillance and immunoediting, with a detailed look at immune cells, immune checkpoints and regulators, sialic acid-binding immunoglobulin-like lectins and other mechanisms. [J Intern Med] Full Article

Visit our reviews page to see a complete list of reviews in the Immune Regulation research field.

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INDUSTRY NEWS
Historic National Coalition Formed to Accelerate Next Generation Immunotherapy in Cancer
Leaders from large pharma including Celgene and Amgen, biotech including NantWorks, NantKwest, Etubics, Altor Bioscience, and Precision Biologics, major academic cancer centers and community oncologists announced the launch of The National Immunotherapy Coalition, a historic alliance—in collaboration with Independence Blue Cross—with a singular focus: accelerating the potential of combination immunotherapies as the next generation standard of care in patients with cancer. [National Immunotherapy Coalition (Business Wire)] Press Release

GE Healthcare, FedDev Ontario Commit CAD $40 Million for New CCRM-Led Center to Solve Cell Therapy Manufacturing Challenges
GE Healthcare, the Federal Economic Development Agency for Southern Ontario (FedDev Ontario), and the Center for Commercialization of Regenerative Medicine (CCRM) are building a center for advanced therapeutic cell technologies in Toronto with an investment of $40 million from GE and FedDev Ontario. [Center for Commercialization of Regenerative Medicine] Press Release

New Study to Investigate How Good Antibodies Go Bad
New research, led by University at Buffalo oral biology researcher Jill Kramer, aims to re-examine whether IgM is pathogenic, or capable of causing disease. The research, “Analysis of the Source and Significance of IgM in Sjögren’s syndrome,” is one of several studies funded through a $16 million Clinical and Translational Science Award provided to UB from the National Institutes of Health. [University at Buffalo] Press Release

Researcher Gets Grant to Study How Immune System Can Prevent Inflammatory Bowel Diseases
A Georgia State University researcher has received a private grant of nearly $300,000 to investigate how the immune system can prevent inflammatory bowel disease. Benoit Chassaing, assistant professor in the Institute for Biomedical Sciences, will study how the adaptive immune system, which protects the body against pathogens, can control intestinal bacteria to prevent inflammation in the gut. [Georgia State University] Press Release

Gritstone Oncology Enters Into Exclusive Licensing Agreement and Collaboration with Memorial Sloan Kettering Cancer Center
Gritstone Oncology announced that the company has entered into an exclusive, worldwide licensing agreement and collaboration with Memorial Sloan Kettering Cancer Center. [Gritstone Oncology] Press Release

Immunotherapy for Epstein-Barr Related Lymphomas: First Health Canada Green Light Goes for Clinical Trial
Health Canada approved, for the first time in Canada, a clinical project for a Phase I study aimed at treating lymphomas associated with the Epstein-Barr virus (EBV) through adoptive cellular immunotherapy that is specific to EBV. [University of Montréal] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Immune Checkpoint Inhibitors 2016
March 15-17, 2016
Boston, United States

Visit our events page to see a complete list of events in the Immune Regulation community.
 
JOB OPPORTUNITIES
NEW Research Fellow – Immunology (Boston Children’s Hospital Harvard Medical School)

Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Cell Therapy (Toronto Western Hospital)

Postdoctoral Position – Immunology (Indiana University)

Postdoctoral Position – Immunology (VIB)

PhD Position – Immunology (VIB)

Postdoctoral Research Fellow – Immunity (Massachusetts General Hospital & Harvard Medical School)

Postdoctoral Position – Immunotherapy Targeting Cancer Stem Cells (Ecole Polytechnique Fédérale de Lausanne)

Postdoctoral Position – Cancer Immunotherapy (Bayer HealthCare AG)

Researchers – Immunotherapy (ISPIC Consortium Members)


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