Volume 7.46 | Dec 4

Immune Regulation News 7.46 December 4, 2015
Immune Regulation News
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Immune Cells Make Appendix ‘Silent Hero’ of Digestive Health
Scientists showed a network of immune cells helps the appendix play a pivotal role in maintaining digestive health, supporting the theory that the appendix isn’t a redundant organ. [Press release from the Walter and Eliza Hall Institute for Medical Research discussing online prepublication in Nature Immunology]
Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Transcriptome Analysis of GvHD Reveals Aurora Kinase A as a Targetable Pathway for Disease Prevention
Researchers measured the gene expression profile of nonhuman primate T cells during acute graft-versus-host disease (GvHD). They were able to identify transcriptomic signatures specific for alloreactive T cells and determine the impact of both mTOR (mechanistic target of rapamycin) and calcineurin inhibition on GvHD. [Sci Transl Med] Abstract | Press Release

Inhibition of the Kinase ITK in a Mouse Model of Asthma Reduces Cell Death and Fails to Inhibit the Inflammatory Response
Investigators found that a small-molecule selective inhibitor of interleukin-2 (IL-2)–inducible T cell kinase (ITK) blocked T cell receptor-mediated signaling in cultured T helper 2 (TH2) cells, including the tyrosine phosphorylation of phospholipase C–γ1 and the secretion of IL-2 and TH2-type cytokines. [Sci Signal] Abstract

Human Embryonic Stem Cell-Derived Mesenchymal Cells Preserve Kidney Function and Extend Lifespan in NZB/W F1 Mouse Model of Lupus Nephritis
Researchers showed that human embryonic stem cell-derived mesenchymal stromal cells (hESC-MSCs) prevent the progression of fatal lupus nephritis in NZB/W F1 (BWF1) mice. In vitro, co-culture of hESC-MSCs with lipopolysaccharide-stimulated BWF1 lymphocytes decreased lymphocyte secretion of tumor necrosis factor alpha and interleukin 6, and enhanced the percentage of putative regulatory T cells. [Sci Rep]
Full Article | Press Release

Specific Immunotherapy in Combination with Clostridium butyricum Inhibits Allergic Inflammation in the Mouse Intestine
An increase in the frequency of the interleukin (IL)-10-producing ovalbumin (OVA)-specific B cell (OVAsBC) was observed in mice in parallel to the inhibitory effect on the intestinal allergic inflammation. The in vitro treatment of the OVAsBCs with OVA increased the histone deacetylase-1 phosphorylation, modulated the transcription of the Bcl6 gene, and triggered the OVAsBCs to differentiate to the IgE-producing plasma cells. [Sci Rep] Full Article

Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes
Using tetramer analysis, scientists demonstrated that chromogranin A (ChgA)-reactive T cells are present in NOD.ChgA−/− mice but remain naive. In contrast, in NOD.ChgA+/+ mice, a majority of the ChgA-reactive T cells are Ag experienced. [J Immunol] Abstract

CD137 Agonist Therapy Can Reprogram Regulatory T Cells into Cytotoxic CD4+ T Cells with Antitumor Activity
The authors used the highly immunogenic Friend virus–induced FBL-3 tumor as a model to study the mechanisms of immunological tumor control by CD4+ T cells in the course of CD137 agonist immunotherapy in the absence of a CD8 T cell response. [J Immunol] Abstract

Pore-Formation by Adenylate Cyclase Toxoid Activates Dendritic Cells to Prime CD8+ and CD4+ T Cells
Scientists showed that the pore-forming activity confers on the adenylate cyclase toxin-hemolysin-AC toxoid a capacity to trigger Toll-like receptor and inflammasome signaling-independent maturation of CD11b-expressing dendritic cells. [Immunol Cell Biol] Abstract

The Role of Regulatory CD4 T Cells in Maintaining Tolerance in a Mouse Model of Autoimmune Hepatitis
Scientists investigated the impact of regulatory CD4 T cells (Treg) in a model of autoimmune hepatitis. Treg isolated from inflamed livers of TF-OVA mice were tested for their functionality in vitro. [PLoS One] Full Article

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Immunopathogenesis of IBD: Current State of the Art
The authors review current knowledge of the classic immune components and will expand the concept of IBD immunopathogenesis to include various cells, mediators and pathways that have not been traditionally associated with disease mechanisms, but that profoundly affect the overall intestinal inflammatory process. [Nat Rev Gastroenterol Hepatol] Abstract

Notch and Its Ligands in Alloimmunity and Rejection
The authors provide an overview of the mechanisms of Notch signaling, focusing on new insights into its diverse functions in T-cell activation, differentiation and memory subset formation, and the consequences thereof in transplantation. [Curr Opin Organ Transplant] Abstract

Visit our reviews page to see a complete list of reviews in the Immune Regulation research field.
Amgen and Merck Announce Cancer Immunotherapy Collaboration for Patients with Non-Hodgkin Lymphoma
Amgen and Merck announced a cancer immunotherapy collaboration to support a Phase Ib/III study investigating BLINCYTO® (blinatumomab) in combination with KEYTRUDA® (pembrolizumab) in patients with diffuse large B-cell lymphoma. [Amgen Inc.] Press Release

TxCell Signs Strategic Agreement with MaSTherCell for European Manufacturing of Its Cell Therapy Products
TxCell SA announced it has signed a five-year agreement with MaSTherCell. TxCell already appointed MaSTherCell for the manufacturing of TxCell’s lead product Ovasave® for the ongoing CATS29 study. CATS29 is a Phase IIb trial of Ovasave conducted in refractory Crohn’s diseases patients. [TxCell SA] Press Release

Andrew and Mary Weinberg Foundation Supports Cancer Immunotherapy Research at UH Cancer Center
The Andrew and Mary Weinberg Foundation has donated $150,000 to establish the Andrew and Mary Weinberg Cancer Immunotherapy Fund at the University of Hawaiʻi (UH) Cancer Center. [University of Hawaiʻi] Press Release

Immunovaccine’s DPX-Survivac Induces an Immune Response in Diffuse Large B Cell Lymphoma
Immunovaccine Inc. announced that the initial results from a Phase II study demonstrated that DPX-Survivac can induce a strong immune response in diffuse large B cell lymphoma tumors. [Immunovaccine Inc.] Press Release

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NEW Cell & Gene Therapy World
January 25-27, 2016
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NEW Open Scientist Positions – Gene and Cell Therapy (Autolus)

NEW Postdoctoral Position – Cancer Immunotherapy (Bayer HealthCare AG)

NEW Researchers – Immunotherapy (ISPIC Consortium Members)

NEW Postdoctoral Position – Immunology (Albert Einstein College of Medicine)

Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.)

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Scientist – Preclinical Immunology (Kanyos Bio)

Postdoctoral Fellow – Regulatory Functions of Immune-Checkpoint Proteins (Medical College of Wisconsin)

Postdoctoral Fellow – Metastatic Breast Cancer (Purdue University Center for Cancer Research)

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