Volume 7.33 | Sep 4

Immune Regulation News 7.33 September 4, 2015
Immune Regulation News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Aspirin Could Hold the Key to Supercharged Cancer Immunotherapy
Combining immunotherapy with aspirin or other COX inhibitors substantially slowed bowel and melanoma skin cancer growth in mice, compared to immunotherapy alone. [Press release from The Francis Crick Institute discussing online prepublication in Cell] Press Release | Full Article | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
CD47 Blockade Triggers T Cell–Mediated Destruction of Immunogenic Tumors
Using syngeneic immunocompetent mouse tumor models, investigators revealed that the therapeutic effects of CD47 blockade depend on dendritic cell but not macrophage cross-priming of T cell responses. The therapeutic effects of anti-CD47 antibody therapy were abrogated in T cell–deficient mice. [Nat Med]
Abstract | Press Release

IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses
Scientists found that IL-36γ stimulated CD8+ T cells, NK cells, and γδ T cells synergistically with TCR signaling and/or IL-12. Importantly, IL-36γ exerted profound antitumor effects in vivo and transformed the tumor microenvironment in favor of tumor eradication. [Cancer Cell] Abstract | Graphical Abstract

The Transcription Factor ATF7 Mediates Lipopolysaccharide-Induced Epigenetic Changes in Macrophages Involved in Innate Immunological Memory
Researchers identified an important role for the stress-response transcription factor ATF7 in innate immunological memory. ATF7 suppressed a group of genes encoding factors involved in innate immunity in macrophages by recruiting the histone H3K9 dimethyltransferase G9a. [Nat Immunol] Abstract | Press Release

Double-Negative αβ T Cells Are Early Responders to AKI and Are Found in Human Kidney
Scientists phenotypically and functionally characterized murine kidney CD4CD8 (double-negative) T cells in the steady state and in response to ischemia-reperfusion injury. [J Am Soc Nephrol] Abstract

Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1low Monocytes
The authors report that in the presence of elevated levels of triglyceride-rich lipoproteins, induced by administration of poloxamer 407, the blood numbers of non-classical Ly6C/Gr1low monocytes drop, while the number of bone marrow progenitors remains similar. [Cell Rep]
Full Article | Graphical Abstract | Press Release

Efficacy of Systemic Adoptive Transfer Immunotherapy Targeting NY-ESO-1 for Glioblastoma
Investigators utilized human glioblastoma cell cultures to induce expression of New York–esophageal squamous cell carcinoma (NY-ESO-1) following in vitro treatment with the demethylating agent decitabine. They examined the in vivo application of this immune therapy using an intracranially implanted xenograft model for in situ T cell trafficking, survival, and tissue studies. [Neuro Oncol] Abstract | Press Release

Inhibition of FOXP3/NFAT Interaction Enhances T Cell Function after TCR Stimulation
Researchers found that a short synthetic peptide able to inhibit FOXP3/NFAT interaction impaired suppressor activity of conventional regulatory T cells in vitro. Specific inhibition of FOXP3/NFAT interaction with this inhibitory peptide revealed that FOXP3 downregulates NFAT-driven promoter activity of CD40L and IL-17. [J Immunol] Abstract

Plasma Phospholipid Transfer Protein (PLTP) Modulates Adaptive Immune Functions through Alternation of T Helper Cell Polarization
Scientists demonstrated that PLTP deficiency in mice has a profound effect on CD4+ Th0 cell polarization, with a shift towards the anti-inflammatory Th2 phenotype under both normal and pathological conditions. [Cell Mol Immunol] Abstract

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Effector T Cell Differentiation: Are Master Regulators of Effector T Cells Still the Masters?
Significant progress has been made in understanding the transcriptional network that drives CD4 T cell differentiation, revealing novel points of regulation mediated by transcription factors, cell surface receptors, cytokines and chemokines. [Curr Opin Immunol] Abstract

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MD Anderson and Cellectis Announce Pre-Clinical and Clinical Alliance in Cancer Immunotherapy
Cellectis and The University of Texas MD Anderson Cancer Center have entered into a research and development alliance aimed at bringing novel cellular immunotherapies to patients suffering from different types of liquid tumors. [The University of Texas MD Anderson Cancer Center] Press Release

Yale Cancer Center Receives $11 Million from National Cancer Institute for Lung Cancer Research
Armed with an $11 million grant from the National Cancer Institute, Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven will launch a new research program in non-small cell lung cancer. Known as a Specialized Program of Research Excellence, or SPORE, the new research program harnesses the strengths of academic cancer centers by bringing together experts in oncology, immunobiology, pharmacology, molecular biology, pathology, epidemiology, and addiction science to collaborate on projects. [Yale University] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW BioChina International 2015 Summit
October 27-28, 2015
Shanghai, China

NEW Global Cancer Summit
November 18-20, 2015
Bangalore, India

NEW Keystone Symposia: T Follicular Helper Cells and Germinal Centers
February 26-March 1, 2016
Monterey, United States

Visit our events page to see a complete list of events in the Immune Regulation community.
NEW Postdoctoral Position – Immunology (Shanghai Institute of Immunology)

Postdoctoral Position – Immunology/Vascular Biology/Cancerology (University of Toulouse)

Postdoctoral Position – Neuroimmunology (Brain and Spine Institute (ICM))

Postdoctoral Research Fellow – Development and Pathogenesis of Pancreatic Cancer (University College London)

Senior Research Technician (Qu Biologics Inc.)

Postdoctoral Fellow – Immunology (The Henry M. Jackson Foundation)

Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Positions – Cancer Research (Rutgers University)

Research Associate – Cell Biology (Editas Medicine)

Senior Research Associate – CRISPR-Based Therapeutics (Editas Medicine)

Research Assistant – Immunotherapy for HIV Infection (California Institute of Technology)

PhD Studentship – Veterinary and Animal Sciences (University of Milan)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

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