Volume 7.29 | Aug 7

Immune Regulation News 7.29 August 7, 2015
Immune Regulation News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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New Insight into How the Immune System Sounds the Alarm
Researchers have discovered that T cell triggering relies on a dynamic protein network at the cell surface. The new discovery shows that T cell receptors are incredibly active—more like a bustling train station, with molecules rapidly coming and going at different intervals of time. [Press release from the Salk Institute discussing online prepublication in Nature Immunology] Press Release | Video | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Control of Signaling-Mediated Clearance of Apoptotic Cells by the Tumor Suppressor p53
Researchers identified a postapoptotic target gene of p53, death domain1α (DD1α), that is responsive to genotoxic stresses and expressed in immune cells. DD1α appeared to function as an immunoregulator of T cell tolerance. They hypothesized that p53 controls signaling-mediated phagocytosis of apoptotic cells through its target, DD1α. [Science] Abstract

Indoleamine 2,3-Dioxygenase Fine-Tunes Immune Homeostasis in Atherosclerosis and Colitis through Repression of Interleukin-10 Production
Investigators showed that indoleamine 2,3-dioxygenase 1 (Ido1) activity sustains an immunostimulatory potential through inhibition of interleukin (Il)10. The resistance of Ido1-deficient mice to enhanced immune activation is broken in Ido1/Il10 double-deficient mice, which show exaggerated immune responses and develop severe spontaneous colitis. [Cell Metab] Abstract | Graphical Abstract

Results of a Preclinical Randomized Controlled Multicenter Trial (pRCT): Anti-CD49d Treatment for Acute Brain Ischemia
Anti-CD49d antibodies, which inhibit the migration of leukocytes into the brain, were previously investigated in experimental stroke models by individual laboratories. To confirm the preclinical results and to test the feasibility of conducting a pRCT, six independent European research centers investigated the efficacy of anti-CD49d antibodies in two distinct mouse models of stroke in a centrally coordinated, randomized, and blinded approach. [Sci Transl Med] Abstract

CD163 Interacts with TWEAK to Regulate Tissue Regeneration after Ischemic Injury
Scientists showed that during ischemia, soluble CD163 functions as a decoy receptor for TWEAK, a secreted pro-inflammatory cytokine of the tumor necrosis factor family, to regulate TWEAK-induced activation of canonical nuclear factor-κB and Notch signaling necessary for myogenic progenitor cell proliferation. [Nat Commun] Full Article | Press Release

Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1
Researchers performed transcriptional profiling of memory phenotype CD4 T cells in high-fat-fed mice and identified acetyl-CoA carboxylase 1 (ACC1, the gene product of Acaca) as an essential regulator of Th17 cell differentiation in vitro and of the pathogenicity of Th17 cells in vivo. [Cell Rep] Full Article | Graphical Abstract

Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species
Researchers examined the mechanism by which plasmacytoid dendritic cells and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody development, which correlated with heightened IFN-γ production by natural killer cells. [Cell Rep] Full Article | Graphical Abstract

Regulatory T-Cell Depletion in the Gut Caused by Integrin β7 Deficiency Exacerbates DSS Colitis by Evoking Aberrant Innate Immunity
Scientists showed that integrin β7 deficiency results in colonic regulatory T cell depletion and exacerbates dextran sulfate sodium (DSS) colitis by evoking aberrant innate immunity. [Mucosal Immunol] Abstract

Non-Classical MHC I-E Negatively Regulates Macrophage Activation and Th17 Cell Development in NOD Mice
Scientists showed that transgenic expression of I-Ek alpha 16 molecule in NOD mice selectively reduced Th17 cells in the thymus and pancreatic draining lymph nodes. The reduction in Th17 cells was associated with both attenuated IL-6 production and decreased activation of macrophages. [Sci Rep] Full Article

A Novel Role of Numb as A Regulator of Pro-Inflammatory Cytokine Production in Macrophages in Response to Toll-Like Receptor 4
The role of Numb as a regulator of inflammatory responses in macrophages was investigated. Murine bone marrow-derived macrophages, in which expression of Numb was silenced, secreted significantly less TNFα, IL-6 and IL-12 and more IL-10 upon activation by lipopolysaccharide, a ligand for Toll-like receptor 4, despite increased Notch signaling. [Sci Rep] Full Article

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G-Protein-Coupled Receptor Kinases in Inflammation and Disease
The authors discuss the classical and the newly emerging functions of G-protein-coupled receptor kinases in the immune system and their role in inflammation and disease processes. [Genes Immun] Abstract

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MabVax Therapeutics and The Rockefeller University Enter into a Collaborative Research Agreement
MabVax Therapeutics Holdings, Inc. and The Rockefeller University’s Laboratory of Molecular Genetics and Immunology have entered into a research collaboration agreement to explore the mechanism of action of constant region variants of the HuMab 5B1 in the role of tumor clearance. [MabVax Therapeutics Holdings, Inc.] Press Release

Bristol-Myers Squibb Establishes Collaborative Immuno-Oncology Rare Population Malignancy (I-O RPM) Program in the U.S.
Bristol-Myers Squibb Company announced the establishment of the I-O RPM program in the U.S. As part of the I-O RPM program, Bristol-Myers Squibb, the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and the Northwestern Medicine Developmental Therapeutics Institute announced that they have entered into a collaboration agreement. [Bristol-Myers Squibb Company] Press Release

Advaxis’s ADXS-PSA Awarded Research Grants from the Prostate Cancer Foundation and the Movember Foundation
Advaxis, Inc. announced two research projects involving the company’s Lm Technology™ immunotherapy candidate ADXS-PSA, which is being developed for prostate cancer, have been selected as 2015 Movember Foundation-PCF Challenge Awards, sponsored by the Movember Foundation and the Prostate Cancer Foundation. [Advaxis, Inc.] Press Release

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NEW Postdoctoral Fellow – Immunology (The Henry M. Jackson Foundation)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Scientific Marketing Specialist – Immunology (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Biotechnology (Qu Biologics Inc.)

Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Positions – Cancer Research (Rutgers University)

Research Associate – Cell Biology (Editas Medicine)

Senior Research Associate – CRISPR-Based Therapeutics (Editas Medicine)

Research Assistant – Immunotherapy for HIV Infection (California Institute of Technology)

Postdoctoral Position – Translational Immunology (University of Utah School of Medicine)

PhD Studentship – Veterinary and Animal Sciences (University of Milan)

Postdoctoral Researcher – Tumorigenesis and Immune Response (Nationwide Children Hospital-Ohio)

Senior Scientist – Immunology (Valera LLC)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

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