Volume 7.26 | Jul 17

Immune Regulation News 7.26 July 17, 2015
Immune Regulation News
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Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia
To improve the efficacy of JAK2 inhibition in B cell acute lymphoblastic leukemia (B-ALL), scientists developed the type II inhibitor CHZ868, which stabilizes JAK2 in an inactive conformation. CHZ868 potently suppressed the growth of CRLF2-rearranged human B-ALL cells, abrogated JAK2 signaling, and improved survival in mice with human or murine B-ALL. [Cancer Cell] Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
Production of IL-10 by CD4+ Regulatory T Cells during the Resolution of Infection Promotes the Maturation of Memory CD8+ T Cells
Researchers found that interleukin 10 (IL-10) derived from CD4+ regulatory T cells was necessary for the maturation of memory CD8+ T cells following acute infection with lymphocytic choriomeningitis virus. [Nat Immunol] Abstract

Steatohepatitis as Impaired Immune Metabolism Induced by Liver Resident Regulatory T-Cell Depletion
Investigators found that steatohepatitis was induced under the condition of temporary depletion of liver-resident regulatory T (Treg) cells combined with a high-fat diet. With the temporary depletion of Treg cells, interferon γ-secreting CD4+ T cells and CD8+ T cells were increased. [Hepatology] Abstract

Depletion of B Cells Induce Remission of Autoimmune Hepatitis in Mice through Reduced Antigen Presentation and Help to T Cells
Scientists aimed to understand the immunological changes underlying the autoimmune hepatitis (AIH) remission caused by B-cell depletion in an experimental model of AIH. [Hepatology] Abstract

Opposing Roles of STAT1 and STAT3 in IL-21 Function in CD4+ T Cells
Researchers investigated the role of STAT1 and showed that STAT1 and STAT3 have at least partially opposing roles in IL-21 signaling in CD4+ T cells. IL-21 induced STAT1 phosphorylation, and this was augmented in Stat3-deficient CD4+ T cells. [Proc Natl Acad Sci USA] Abstract

Self-Recognition Drives the Preferential Accumulation of Promiscuous CD4 T-Cells in Aged Mice
Scientists report that, while old mice contain fewer CD4+ T-cells compared with adults, those that remain have a higher intrinsic affinity for self-major histocompatibility complex molecules, as measured by CD5 expression. [Elife] Full Article

Selective Involvement of the Checkpoint Regulator VISTA in Suppression of B-Cell, but Not T-Cell, Responsiveness by Monocytic Myeloid Derived Suppressor Cells from Mice Infected by an Immunodeficiency-Causing Retrovirus
Researchers demonstrated augmentation of monocytic myeloid-derived suppressor cells whose suppression of not only T-, but also B-cell, responsiveness paralleled the immunodeficiency during LP-BM5 retrovirus infection. [J Virol] Abstract

Transcription Factor IRF8 Controls Th1-Like Regulatory T-Cell Function
Scientists discovered that transcription factor interferon regulatory factor 8 (IRF8) was selectively expressed in regulatory T and Th1 cells. IRF8-deficient Treg cells showed defective expression of CXCR3 and aberrant expression of the Il4 and Il17 genes. [Cell Mol Immunol] Abstract

PARP Inhibition by Olaparib or Gene Knockout Blocks Asthma-Like Manifestation in Mice by Modulating CD4+ T Cell Function
Investigators examined the efficacy of olaparib in blocking established allergic airway inflammation and hyperresponsiveness similar to those observed in human asthma in animal models of the disease. [J Transl Med] Full Article

Pre-Vaccination Frequencies of Th17 Cells Correlate with Vaccine-Induced T-Cell Responses to Survivin-Derived Peptide Epitopes
Scientists performed an exploratory analysis of a possible correlation of pre-vaccination Th17 cells, myeloid derived suppressor cells , and regulatory T cells with both vaccination-induced T-cell responses as well as clinical outcome in metastatic melanoma patients vaccinated with survivin-derived peptides. [PLoS One] Full Article

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Origin and Functions of Pro-Inflammatory Cytokine Producing Foxp3+ Regulatory T Cells
Toll-like receptor ligands and the pro-inflammatory cytokine milieu have been shown to play important roles in the induction of effector cytokines in CD4+CD25+Foxp3+ regulatory cells (Tregs). The authors review the mechanisms of development and the possible functions of pro-inflammatory cytokine producing Foxp3+ Tregs. [Cytokine] Abstract

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Immunovaccine and PharmAthene Sign Exclusive Worldwide License Agreement to Develop and Commercialize an Anthrax Vaccine Formulated in DepoVax™
Immunovaccine Inc. announced that it has entered into an exclusive worldwide license agreement with PharmAthene, Inc. to develop and commercialize a Recombinant Protective Antigen Anthrax vaccine candidate utilizing Immunovaccine’s proprietary DepoVax™ vaccine platform. [Immunovaccine Inc.] Press Release

Vanderbilt University Medical Center Joins Human Vaccines Project as First Scientific Hub
Vanderbilt University Medical Center (VUMC), the Human Vaccines Project and the International AIDS Vaccine Initiative are pleased to announce that VUMC has become the Project’s first scientific hub. [International AIDS Vaccine Initiative] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cell Symposium: Human Immunity and the Microbiome in Health and Disease
September 27-29, 2015
Montreal, Canada

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NEW Research Assistant – Immunotherapy for HIV Infection (California Institute of Technology)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Scientific Marketing Specialist – Immunology (STEMCELL Technologies Inc.)

Postdoctoral Position – Translational Immunology (University of Utah School of Medicine)

PhD Studentship – Veterinary and Animal Sciences (University of Milan)

Postdoctoral Researcher – Tumorigenesis and Immune Response (Nationwide Children Hospital-Ohio)

Senior Scientist – Immunology (Valera LLC)

Postdoctoral Fellow – Antibody Engineering/Immuno-Oncology (California Institute for Biomedical Research)

Associate Director/Director – Immunology (Valera)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

Process Facilitator (Opexa Therapeutics)

Assistant Professor – Immunology (Northwestern University)

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