Volume 7.25 | Jul 10

Immune Regulation News 7.25 July 10, 2015
Immune Regulation News
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The Role of the Microbiota in Preventing Allergies
It is well established that a loss of bacterial symbionts promotes the development of allergies. Scientists have succeeded in explaining this phenomenon, and demonstrate how the microbiota acts on the balance of the immune system: the presence of microbes specifically blocks the immune cells responsible for triggering allergies. [Press release from Institut Pasteur discussing online prepublication in Science]
Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
An Interactive Reference Framework for Modeling a Dynamic Immune System
Researchers set out to initiate an immune system reference framework to provide a working definition of immune organization and enable the integration of new data sets. [Science] Abstract

A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner
Investigators found that under physiologic conditions and during autoimmune inflammation or viral infection, some immunological functions of microRNA (miRNA)-155 were fully or largely attributable to the regulation of SOCS1, whereas others could be accounted only partially or not at all by this interaction. [Immunity] Abstract

The Transcription Factor XBP1 Is Selectively Required for Eosinophil Differentiation
Scientists discovered an unexpectedly selective and absolute requirement for XBP1 in eosinophil differentiation without an effect on the survival of basophils or neutrophils. [Nat Immunol]
Abstract | Press Release | Video

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease
Investigators showed that a high-fat diet (HFD)-derived ileum microbiota is responsible for a decrease in Th17 cells of the lamina propria in axenic colonized mice. The HFD also changed the expression profiles of intestinal antigen-presenting cells and their ability to generate Th17 cells in vitro. [Cell Metab]
Abstract | Graphical Abstract

Spontaneous Restoration of Transplantation Tolerance after Acute Rejection
Using a mouse model of cardiac transplantation, scientists showed that when Listeria monocytogenes infection precipitates acute rejection, thus abrogating transplantation tolerance, the donor-specific tolerant state re-emerges, allowing spontaneous acceptance of a donor-matched second transplant. [Nat Commun]
Full Article | Press Release

CD300f Associates with IL-4 Receptor α and Amplifies IL-4–Induced Immune Cell Responses
Researchers identified the myeloid-associated Ig receptor CD300f as an IL-4–induced molecule in macrophages. Using Cd300f−/− cells and receptor cross-linking experiments, they established that CD300f amplified IL-4Rα–induced responses by augmenting IL-4/IL-13–induced signaling, mediator release, and priming. [Proc Natl Acad Sci USA] Abstract

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging
The authors demonstrate an increase in the ratio of inhibitory T follicular regulatory cells to stimulatory T follicular helper cells in aged mice. [Cell Rep] Full Article | Graphical Abstract

Critical Role of the NKG2D Receptor for NK Cell-Mediated Control and Immune Escape of B-Cell Lymphoma
By using transplantable tumors as well as a λ-myc-transgenic model of endogenously arising lymphoma and NK group 2D (NKG2D)-deficient mice, investigators showed that NK cells eliminate tumor cells in vivo after receiving two signals. [Eur J Immunol] Abstract | Press Release

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Only One of These Antibodies Will Work for Your Cell Analysis. We Take the Guesswork Out of Finding the Right
The Multifaceted Biology of Plasmacytoid Dendritic Cells
The authors summarize recent progress in the field of plasmacytoid dendritic cell (pDC) biology, focusing on the molecular mechanisms that regulate the development and functions of pDCs, the pathways involved in their sensing of pathogens and endogenous nucleic acids, their functions at mucosal sites, and their roles in infection, autoimmunity and cancer. [Nat Rev Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the immune regulation research field.
Ludwig Cancer Research and the Cancer Research Institute Evaluate Immunotherapeutic Strategies for Brain Cancer and Other Types of Solid Tumors
Ludwig Cancer Research and the Cancer Research Institute have launched clinical trials evaluating an immunotherapy for the treatment of the brain cancer glioblastoma multiforme and a combination of immunotherapies for a variety of solid tumors. [Ludwig Cancer Research] Press Release

Ludwig Cancer Research and University of Oxford Launch Cancer Immunotherapy Spinout
Isis Innovation, the University of Oxford’s technology commercialization company, and Ludwig Cancer Research announced the launch of a new spinout company, iOx Therapeutics. iOx Therapeutics will develop a novel cancer immunotherapy discovered through a collaboration between Ludwig Cancer Research and Professor Vincenzo Cerundolo within the University of Oxford’s Weatherall Institute of Molecular Medicine. [Ludwig Cancer Research] Press Release

apceth and University of Cologne to Join Forces on Combination Cellular Immunotherapies for Cancer
apceth announced a broad partnership with the Center for Molecular Medicine Cologne, University of Cologne, to combine technologies and expertise, on the development of immunotherapies for solid tumors and hematological malignancies. [apceth®] Press Release

TSRI Scientists Win $1.2 Million Grant to Study Environmental Triggers of Lupus and Rheumatoid Arthritis
Researchers from The Scripps Research Institute (TSRI) have received a grant of more than $1.2 million from the National Institute of Environmental Health Sciences’ ViCTER (Virtual Consortium for Translational/Transdisciplinary Environmental Research) program to augment existing research into how environmental factors trigger such autoimmune diseases. [The Scripps Research Institute] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Frontiers in Basic Immunology 2015
October 8-9, 2015
Bethesda, United States

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NEW Postdoctoral Position – Translational Immunology (University of Utah School of Medicine)

NEW PhD Studentship – Veterinary and Animal Sciences (University of Milan)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Scientific Marketing Specialist – Immunology (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Tumorigenesis and Immune Response (Nationwide Children Hospital-Ohio)

Senior Scientist – Immunology (Valera LLC)

Postdoctoral Fellow – Antibody Engineering/Immuno-Oncology (California Institute for Biomedical Research)

Associate Director/Director – Immunology (Valera)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

Process Facilitator (Opexa Therapeutics)

Postdoctoral Fellow – Immune Tolerance (Stanford University)

Assistant Professor – Immunology (Northwestern University)

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