Researchers Expose How ‘James Bond’ Cells Are Made
Researchers revealed how immune cell ‘spies’ are created, providing clues on how the immune system could be manipulated to better fight disease. [Press release from the Walter and Eliza Hall Institute discussing online prepublication in Nature Immunology] Press Release|Abstract
Active Targeting of Chemotherapy to Disseminated Tumors Using Nanoparticle-Carrying T Cells
In a murine model of disseminated lymphoma, researchers expanded autologous polyclonal T cells ex vivo under conditions that retained homing receptors mirroring lymphoma cells, and functionalized these T cells to carry SN-38–loaded nanocapsules on their surfaces. Nanocapsule-functionalized T cells were resistant to SN-38 but mediated efficient killing of lymphoma cells in vitro. [Sci Transl Med] Abstract
Inflammation Negatively Regulates FOXP3 and Regulatory T-Cell Function via DBC1
The authors report that Deleted in breast cancer 1 (DBC1) is a key subunit of the forkhead box P3 (FOXP3) complex. Treg cells from Dcb1-deficient mice were more resistant to inflammation-mediated abrogation of Foxp3 expression and function and delayed the onset and severity of experimental autoimmune encephalomyelitis and colitis in mice. [Proc Natl Acad Sci USA] Abstract
Focusing and Sustaining the Antitumor CTL Effector Killer Response by Agonist Anti-CD137 mAb
The marked synergistic effects of adoptive T cell and agonist anti-CD137 monoclonal Ab (mAbs) therapies were studied, providing in vivo evidence for improved, more sustained and focused tumoricidal functions of antitumor cytotoxic T lymphocytes (CTLs) when under the influence of CD137-targeted pharmacological stimulation with immunostimulatory monoclonal antibodies. [Proc Natl Acad Sci USA] Abstract
Immunosuppressive Potential of Human Amnion Epithelial Cells in the Treatment of Experimental Autoimmune Encephalomyelitis
Scientists investigated the immunoregulatory effects of human amnion epithelial cells (hAECs) as a potential therapy in a multiple sclerosis-like disease, experimental autoimmune encephalomyelitis, in mice. In vitro, hAECs suppressed both specific and non-specific T cell proliferation, decreased pro-inflammatory cytokine production, and inhibited the activation of stimulated T cells. [J Neuroinflammation] Full Article
Relevance of Foxp3+ Regulatory T Cells for Early and Late Phases of Murine Sepsis
To specifically evaluate the role of Foxp3+ regulatory T cells (Tregs) in the early and late phases of sepsis, investigators induced sepsis by cecal ligation and puncture and subsequent Pseudomonas aeruginosa lung infection in a DEREG mouse model. They found an increase of Foxp3+ Tregs to all CD4+ T cells during murine sepsis. [Immunology] Abstract
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SCIENCE NEWS
Prothena’s NEOD001 Protein Immunotherapy Clinical Data Highlighted in Oral Presentation
Prothena Corporation plc announced that Dr. Michaela Liedtke of Stanford University School of Medicine presented data from the ongoing Phase I/II trial of NEOD001 in patients with AL amyloidosis and persistent organ dysfunction in an oral presentation. [Press release from Prothena Corporation plc discussing research presented at the 20th Congress of the European Hematology Association (EHA), Vienna] Press Release
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