Volume 7.11 | Mar 27

Immune Regulation News 7.11 March 27, 2015
Immune Regulation News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Zinc Deficiency Linked to Immune System Response, Particularly in Older Adults
Researchers set out to better understand the relationship between zinc deficiency and inflammation. They conducted experiments that indicated zinc deficiency induced an increase in inflammatory response in cells. [Press release from Oregon State University discussing online prepublication in Molecular Nutrition & Food Research] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
CD5 Instructs Extrathymic Regulatory T Cell Development in Response to Self and Tolerizing Antigens
Investigators report that CD5, whose expression is upregulated in T cells by self and tolerizing antigens in the thymus and periphery, governed extrathymic regulatory T (Treg) cell development. CD5 modified effector cell-differentiating signals that inhibit Treg cell induction. [Immunity] Abstract | Graphical Abstract

Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus
Researchers showed that selective ablation of inducible T cell costimulator ligand (ICOSL) in CD11c+ cells, but not in B cells, dramatically ameliorated kidney and lung inflammation in lupus-prone MRL.Faslpr mice. Autoantibody formation was largely unaffected by ICOSL deficiency in CD11c+ cells. [Immunity] Abstract

A Dynamic Spectrum of Monocytes Arising from the In Situ Reprogramming of CCR2+ Monocytes at a Site of Sterile Injury
Using spinning-disk confocal intravital microscopy, scientists were able to track the dynamic spectrum of monocytes that enter a site of sterile hepatic injury in vivo. These monocytes transitioned, in situ, from CCR2hiCx3CR1low to CX3CR1hiCCR2low within the ringlike structure and then entered the injury site. [J Exp Med] Abstract

Myeloid Cell-Derived ​Inducible Nitric Oxide Synthase Suppresses M1 Macrophage Polarization
Researchers showed that ​inducible nitric oxide synthase (NOS)-deficient mice displayed enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2 macrophages. ​Endothelial NOS and ​​neuronal NOS mutant mice showed comparable M1 macrophage polarization compared with wild-type control mice. [Nat Commun] Full Article

Orphan Receptor ​IL-17RD Regulates Toll-Like Receptor Signaling via SEFIR/TIR Interactions
Researchers describe a role for the orphan receptor ​interleukin-17 receptor D (​IL-17RD) in negatively regulating Toll-like receptor (TLR)-induced responses. Deficiency of ​IL-17RD expression in cells leads to enhanced pro-inflammatory signaling and gene expression in response to TLR stimulation, and ​Il17rd−/− mice are more susceptible to TLR-induced septic shock. [Nat Commun] Abstract

Dynamin 2-Dependent Endocytosis Sustains T-Cell Receptor Signaling and Drives Metabolic Reprogramming in T Lymphocytes
Using genetic inhibition of endocytosis, scientists showed that T-cell receptor (TCR) internalization promoted continued TCR signaling and T-lymphocyte proliferation. T-cell-specific deletion of dynamin 2, an essential component of endocytosis, resulted in reduced TCR signaling strength, impaired homeostatic proliferation, and the inability to undergo clonal expansion in vivo. [Proc Natl Acad Sci USA] Abstract

Age-Associated Inflammation Connects RAS-Induced Senescence to Stem Cell Dysfunction and Epidermal Malignancy
Investigators showed that mutant H-Ras activation in mouse epidermis, a frequent event in cutaneous squamous cell carcinoma, elicits a differential outcome in aged versus young mice. Progression was associated with increased inflammation, pronounced accumulation of immune cells including T cells, macrophages and mast cells as well as excessive cell senescence. [Cell Death Dis] Abstract

Antigen Design Enhances the Immunogenicity of Semliki Forest Virus-Based Therapeutic Human Papillomavirus Vaccines
Scientists generated, characterized and evaluated the efficacy of recombinant Semliki Forest virus replicon particles expressing human papillomavirus E6 and/or E7 proteins fused to several helper T-cell epitopes and an ER targeting signal. They showed that inclusion of a helper cassette and an ER targeting signal enhanced protein stability and markedly augmented the frequencies of human papillomavirus-specific T cells. [Gene Ther] Abstract

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REVIEWS
Eosinophils in Mucosal Immune Responses
The authors review the basic biology of eosinophils and focus on new emerging concepts about their role in mucosal immune homeostasis, particularly maintenance of intestinal IgA. They review emerging data about their development and regulation and describe new concepts concerning mucosal eosinophilic diseases. [Mucosal Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the immune regulation research field.
 
SCIENCE NEWS
New Data Investigating Merck’s KEYTRUDA® (Pembrolizumab) in Advanced Non-Small Cell Lung Cancer and Mesothelioma
Merck announced that new data evaluating KEYTRUDA®, the company’s anti-PD-1 therapy, in both advanced non-small cell lung cancer and malignant pleural mesothelioma will be presented. [Press release from Merck & Co., Inc. discussing research to be presented at the American Association for Cancer Research (AACR) Annual Meeting, Philadelphia] Press Release

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INDUSTRY NEWS
Qu Biologics Begins Research Collaboration with the University of Rochester, New York
Qu Biologics Inc. announced it has initiated a research collaboration with the laboratory of Dr. Michael R. Elliott of the University of Rochester School of Medicine and Dentistry. [Qu Biologics Inc.] Press Release

Taconic Biosciences and Cellaria Biosciences Agree to Scientific Collaboration to Facilitate Xenograft Use in Oncology Research
Taconic Biosciences and Cellaria Biosciences announced that the two companies have entered into a scientific collaboration designed to facilitate and improve the utility of patient-derived xenografts in animal models for oncology and immuno-oncology research. [Taconic Biosciences, Inc.] Press Release

Sanofi Pasteur Announces FDA Approval of Quadracel DTaP-IPV Vaccine for Children Four through Six Years of Age
Sanofi Pasteur announced that the U.S. Food and Drug Administration (FDA) has approved use of Quadracel™ vaccine for active immunization against diphtheria, tetanus, pertussis and poliomyelitis in children four through six years of age. [Sanofi Pasteur SA] Press Release

THERAVECTYS Granted Authorization by the French National Agency for Medicines to Produce Lentiviral Vectors for Clinical Use and CAR-T Cell Therapies under GMP Standards
THERAVECTYS announced that its manufacturing plant has been granted the status of a GMP pharmaceutical manufacturing establishment, by the French National Agency for Medicines and Health Products Safety. [THERAVECTYS] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Webinar – Effectively Targeting the Kv1.3 Channel: A New Approach to Address Multiple Autoimmune Diseases
April 2, 2015 10:00 AM PDT
Online

NEW Signal Transduction in the Immune System
June 7-12, 2015
Big Sky, United States

NEW International Workshop on Artificial Immune Systems (AIS 2015)
July 17-18, 2015
Taormina, Italy

Visit our events page to see a complete list of events in the immune regulation community.
 
JOB OPPORTUNITIES
NEW Faculty Position – Immunology (Northwestern University)

NEW Postdoctoral Position – Immunology (The Broad Institute of MIT and Harvard)

NEW Immunology Research Fellow (Boston Children’s Hospital)

Postdoctoral Position – Genome Dynamics in the Immune System (Imagine Institute)

Manufacturing Manager – Cell Therapy (Opexa Therapeutics)

Postdoctoral Research Fellow – Molecular Aspects of Autoimmunity (Singapore Immunology Network A*STAR)

PhD Studentship – Mouse Models of Asthma (University of Queensland)

Postdoctoral Researcher – Tumor Immunology and Immunotherapy (Cleveland Clinic Lerner Research Institute)

Assistant/Associate Professor – Gastroenterology (North Carolina State University College of Veterinary Medicine)


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