Volume 7.08 | Mar 6

Immune Regulation News 7.08 March 6, 2015
Immune Regulation News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Researchers Find Inhaling Supplemental Oxygen Can Awaken Anti-​​Tumor Cells
Researchers have found that inhaling sup­ple­mental oxygen—40 to 60 percent oxygen as opposed to the 21 percent oxygen in air—can weaken immuno­sup­pres­sion and awaken anti-​​tumor cells. [Press release from Northeastern University discussing an online publication in Science Translational Medicine]
Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
NK Cells Link Obesity-Induced Adipose Stress to Inflammation and Insulin Resistance
Obesity drove the upregulation of ligands of the natural killer (NK) cell-activating receptor NCR1 on adipocytes; this stimulated NK cell proliferation and interferon-γ production, which in turn triggered the differentiation of proinflammatory macrophages and promoted insulin resistance. [Nat Immunol] Abstract

Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance
Scientists showed that trans-signaling recruited macrophages into adipose tissue (ATM). Moreover, blocking trans-signaling with soluble gp130Fc protein prevented high-fat diet-induced ATM accumulation, but did not improve insulin action. [Cell Metab] Abstract | Graphical Abstract

The Cholesterol Transporter ​ABCG1 Links ​Cholesterol Homeostasis and Tumor Immunity
Investigators showed that reduced tumor growth in ​ATP-binding cassette transporter G1 (​Abcg1)−/− mice was myeloid cell intrinsic and was associated with a phenotypic shift of the macrophages from a tumor-promoting M2 to a tumor-fighting M1 within the tumor. [Nat Commun] Abstract

Generation of Cellular Immune Memory and B-Cell Immunity Is Impaired by Natural Killer Cells
Researchers showed that mouse natural killer cells inhibited generation of long-lived virus-specific memory T- and B cells as well as virus-specific antibody production after acute infection. [Nat Commun] Abstract

Coincidental Loss of DOCK8 Function in NLRP10-Deficient and C3H/HeJ Mice Results in Defective Dendritic Cell Migration
Using a proteomic approach, researchers discovered that dendritic cells from Nlrp10 (NLR family, pyrin domain containing 10) knockout mice lacked the guanine nucleotide exchange factor DOCK8 (dedicator of cytokinesis 8), which regulated cytoskeleton dynamics in multiple leukocyte populations; in humans, loss-of-function mutations in Dock8 resulted in severe immunodeficiency. [Proc Natl Acad Sci USA] Abstract

Nuclear Matrix Binding Protein SMAR1 Regulates T-Cell Differentiation and Allergic Airway Disease
The authors report an essential role of the matrix attachment region (MAR)-binding protein SMAR1 in regulating immune response during allergic airway disease. Conditional knockout of SMAR1 in T cells rendered the mice resistant to eosinophilic airway inflammation against ovalbumin allergen with low immunoglobulin E and interleukin-5 levels. [Mucosal Immunol] Full Article

Control of IL-17 Receptor Signaling and Tissue Inflammation by the p38α-MKP-1 Signaling Axis in a Mouse Model of Multiple Sclerosis
Researchers describe the time- and tissue-specific roles of the mitogen-activated protein kinase p38α in mediating T helper 17 cell-induced tissue inflammation. [Sci Signal] Abstract

miR-21 Controls In Situ Expansion of CCR6+ Regulatory T Cells through PTEN/AKT Pathway in Breast Cancer
Investigators reported that miR-21 was highly expressed in CCR6+ regulatory T cells (Tregs) in tumor tissues from a murine breast cancer model and silencing of miR-21 could significantly reduce the proliferation of CCR6+ Tregs in vitro. [Immunol Cell Biol] Abstract

Tolerance of Activated Pathogenic CD4+ T Cells by Transcriptional Targeting of Dendritic Cells
The authors demonstrate that targeted expression of myelin oligodendrocyte glycoprotein to dendritic cells with self-inactivating-lentivirus vectors induces tolerance of activated antigen-specific CD4+ T cells and completely protects mice from passive experimental autoimmune encephalomyelitis induction. [Gene Ther] Abstract

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March Magnet Maddness: Free EasySep™ Magnet with Purchase of Cell Isolation Reagents
 
REVIEWS
From Mysterious Supernatant Entity to miRNA-150 in Antigen-Specific Exosomes: A History of Hapten-Specific T Suppressor Factor
The authors briefly summarize their studies on T suppressor factor that led to the discovery of regulating miRNA that acts antigen specifically to suppress immune response. [Arch Immunol Ther Exp] Full Article

Visit our reviews page to see a complete list of reviews in the immune regulation research field.

Register for Immune Checkpoint Inhibitors!
 
INDUSTRY NEWS
FDA Approves Opdivo (Nivolumab) for the Treatment of Patients with Previously Treated Metastatic Squamous Non-Small Cell Lung Cancer
Bristol-Myers Squibb Company announced that the U.S. Food and Drug Administration (FDA) has approved Opdivo injection, for intravenous use, for the treatment of patients with metastatic squamous non-small cell lung cancer with progression on or after platinum-based chemotherapy. [Bristol-Myers Squibb Company] Press Release

BioMmune Announces Anti-Cancer Activity Achieved by Restoring Immune Recognition and Killing of Tumor Cells
BioMmune Technologies Inc. has demonstrated in vivo, effective anti-cancer activity induced by new small molecule drugs that make cancer cells more visible to the immune system. [BioMmune Technologies Inc. (Marketwire LP)] Press Release

arGEN-X Expands Preclinical Pipeline with ARGX-115: A Novel Simple Antibody™ for Cancer Immunotherapy
arGEN-X N.V. announced that it has exercised its option to exclusively license a first-in-class, preclinical therapeutic antibody candidate, now ARGX-115, to target GARP, a novel immune checkpoint with potential in cancer immunotherapy. [arGEN-X N.V.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 24th Annual Canadian Association for HIV Research (CAHR) Conference 2015
April 30-May 3, 2015
Toronto, Canada

Visit our events page to see a complete list of events in the immune regulation community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Fellow – Molecular Aspects of Autoimmunity (Singapore Immunology Network A*STAR)

Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

PhD Studentship – Mouse Models of Asthma (University of Queensland)

Lecturer – Cancer Immunology (Plymouth University)

Postdoctoral Researcher – Tumor Immunology and Immunotherapy (Cleveland Clinic Lerner Research Institute)

Postdoctoral Associate – Oligonucleotide Aptamer-Based Compounds to Protect Tumor Vaccine-Induced Immune Cells (University of Miami)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Assistant/Associate Professor – Gastroenterology (North Carolina State University College of Veterinary Medicine)

Postdoctoral Position – HIV and Ebolavirus (University of Missouri)


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