Volume 7.07 | Feb 27

Immune Regulation News 7.07 February 27, 2015
Immune Regulation News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Regulation of Immune Responses to Protein Therapeutics by Transplacental Induction of T Cell Tolerance
Scientists demonstrate that Fc-fused antigens administered to pregnant mice reach fetal lymphoid organs in an Fc receptor-dependent manner, accumulate in antigen-presenting cells of myeloid origin, and promote the generation of both thymic and peripheral antigen-specific regulatory T cells. [Sci Transl Med] Abstract
March Magnet Maddness: Free EasySep™ Magnet with Purchase of Cell Isolation Reagents
 
PUBLICATIONS (Ranked by impact factor of the journal)
Developing In Vitro Expanded CD45RA+ Regulatory T Cells as an Adoptive Cell Therapy for Crohn’s Disease
To define the optimum population for regulatory T (Treg) cell therapy in Crohn’s disease, CD4+CD25+CD127loCD45RA+ and CD4+CD25+CD127loCD45RA Treg subsets were isolated from patients’ blood and expanded in vitro using a workflow that can be readily transferred to a good manufacturing practice background. [Gut] Full Article

Deltex1 Antagonizes ​HIF-1α and Sustains the Stability of Regulatory T Cells In Vivo
Researchers identified a requirement for ​Deltex1 (​DTX1), a contributor to T-cell anergy and ​Foxp3 protein level maintenance in vivo. ​Dtx1−/− regulatory T cells (Tregs) are as effective as WT Tregs in the inhibition of ​CD4+​CD25 T-cell activation in vitro. However, the suppressive ability of ​Dtx1−/− Tregs is greatly impaired in vivo. [Nat Commun] Full Article

TGF-β3-Expressing ​CD4+​CD25​LAG3+ Regulatory T Cells Control Humoral Immune Responses
The authors demonstrate that CD4+​CD25​LAG3+ regulatory T cells (​LAG3+ Treg) produce high amounts of ​TGF-β3 in an ​Egr2 and ​Fas-dependent manner. ​LAG3+ Treg require ​TGF-β3 to suppress B-cell responses in a murine model of lupus. [Nat Commun] Full Article

Dendritic Cell SIRT1-HIF1α Axis Programs the Differentiation of CD4+ T Cells through IL-12 and TGF-β1
Investigators found that sirtuin 1, a type III histone deacetylase, plays an essential role in mediating proinflammatory signaling in dendritic cells, consequentially modulating the balance of proinflammatory T helper type 1 cells and antiinflammatory Foxp3+ regulatory T cells. [Proc Natl Acad Sci USA] Abstract

β-Catenin in Dendritic Cells Exerts Opposite Functions in Cross-Priming and Maintenance of CD8+ T Cells through Regulation of IL-10
The authors report that activation of β-catenin in dendritic cells inhibits cross-priming of CD8+ T cells by up-regulating mTOR-dependent IL-10, suggesting blocking β-catenin/mTOR/IL-10 signaling as a viable approach to augment CD8+ T-cell immunity. [Proc Natl Acad Sci USA] Abstract

IκBNS Regulates Murine Th17 Differentiation during Gut Inflammation and Infection
Scientists analyzed the role of the unusual inhibitor of NF-κB, IκBNS, in the proliferation and effector cytokine production of murine Th17 cells. They demonstrated that nuclear IκBNS is crucial for murine Th17 cell generation. [J Immunol] Abstract

Chitosan Hydrogel Vaccine Generates Protective CD8 T Cell Memory against Mouse Melanoma
Investigators found that vaccination with chitosan hydrogel or dendritic cells using ovalbumin protein as a model antigen and Quil-A adjuvant provided protection in a subcutaneous melanoma challenge 30 days later. [Immunol Cell Biol] Abstract

The Roles of T Helper Type 17/Regulatory T Cells in Acute Rejection after Liver Transplantation in Rats
Scientists investigated the imbalance between T helper type 17 and CD4+CD25+Foxp3+ regulatory T cells during hepatic allograft rejection in a rodent grafts model. [Transplantation] Abstract

Exosomes from Dendritic Cells Loaded with Chaperone-Rich Cell Lysates Elicit a Potent T Cell Immune Response against Intracranial Glioma in Mice
The dendritic cell (DC)-derived exosomes (DEXs) generated from DCs loaded with chaperone-rich cell lysates (CRCLs) derived from GL261 glioma cells were found to promote cell proliferation and cytotoxic T lymphocyte activity of CD4+ and CD8+ T cells in vitro compared with DEX (GL261)-DCs, which were loaded with DEXs derived from DCs loaded with GL261 tumor cell lysates. [J Mol Neurosci] Abstract

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REVIEWS
Emerging Role of IL-16 in Cytokine-Mediated Regulation of Multiple Sclerosis
The authors outline immune pathogenesis of the disease necessary to understand significance of cytokines and IL-16 in multiple sclerosis (MS) regulation. They revisit cytokine regulation with emphasis on involvement of IL-16 mechanisms, implicated in MS progression and important for development of new therapies. [Cytokine] Abstract

Visit our reviews page to see a complete list of reviews in the immune regulation research field.
 
SCIENCE NEWS
Celsion Corporation Presents Clinical and Preclinical Data for GEN-1 IL-12 Immunotherapy in Ovarian Cancer
Celsion Corporation presented clinical and preclinical data demonstrating the safety, biological activity and clinical benefits of GEN-1, its DNA-based immunotherapy, as a single agent in advanced platinum-resistant and recurrent ovarian cancer patients. [Press release by Celsion Corporation discussing research presented at the Molecular Medicine TRI-Conference, San Francisco] Press Release

Nodality Inc. Presents Data from Immuno-Oncology Program Applying Company’s Novel Single Cell Network Profiling (SCNP) Platform
Nodality, Inc. announced research results from its lead immuno-oncology efforts based on applications of the company’s SCNP technology. [Press release by Nodality, Inc. discussing research presented at the Molecular Medicine TRI-Conference, San Francisco] Press Release

Advaxis to Present at International Anal Neoplasia Society Scientific Meeting 2015
Advaxis, Inc. announced that an abstract related to ADXS-HPV, the Company’s lead Lm-LLO immunotherapy product candidate, has been selected for oral presentation. [Press release from Advaxis, Inc. discussing research presented at the International Anal Neoplasia Society (IANS) Scientific Meeting 2015, Atlanta] Press Release

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INDUSTRY NEWS
Orca Pharmaceuticals and AstraZeneca Announce Development Partnership to Identify Best-in-Class RORγ Inhibitors to Treat Autoimmune Disease
Orca Pharmaceuticals, and AstraZeneca announced a three year collaboration to develop inhibitors of retinoic acid–related orphan nuclear receptor gamma (RORγ). [Orca Pharmaceuticals] Press Release

A Novel Immunotherapy Technique to Treat Patients with Osteosarcoma and Neuroblastoma
A novel Phase I clinical trial that leverages T-cell immunotherapy is now under way at Karmanos Cancer Institute and Memorial Sloan-Kettering Cancer Center; bringing new hope to children and young adults with osteosarcoma and neuroblastoma. [Solving Kids’ Cancer] Press Release

Gradalis, Inc. Announces Initiation of a Phase III Registration Study for Vigil™ in Ovarian Cancer
Gradalis Inc. announced that it has initiated a Phase III registration trial for its proprietary autologous immunotherapy, Vigil™, in the treatment of women with stage III/IV ovarian cancer. [Gradalis Inc.] Press Release

ISA Pharmaceuticals Announces Start of First Phase I/II Clinical Trial of Its SLP®-AMPLIVANT® Conjugates
ISA Pharmaceuticals B.V. announced the start of an investigator-initiated Phase I/II clinical trial of a novel immunotherapeutic based on ISA Pharmaceuticals´ platform technology. The trial will be conducted by the Department of Clinical Oncology at Leiden University Medical Center in The Netherlands. [ISA Pharmaceuticals B.V.] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW CAR-T CELLS Stem Memory versus Mature T Cells
March 18, 2015 11:00 AM PST
Online

NEW Immunogenicity 2015
June 29-30, 2015
London, United Kingdom

Visit our events page to see a complete list of events in the immune regulation community.
 
JOB OPPORTUNITIES
NEW PhD Studentship – Mouse Models of Asthma (University of Queensland)

Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Lecturer – Cancer Immunology (Plymouth University)

Postdoctoral Researcher – Tumor Immunology and Immunotherapy (Cleveland Clinic Lerner Research Institute)

Postdoctoral Associate – Oligonucleotide Aptamer-Based Compounds to Protect Tumor Vaccine-Induced Immune Cells (University of Miami)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Assistant/Associate Professor – Gastroenterology (North Carolina State University College of Veterinary Medicine)

Postdoctoral Fellowship – CNS Inflammation (Rutgers University)

Postdoctoral Position – HIV and Ebolavirus (University of Missouri)


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