| | | PUBLICATIONS (Ranked by impact factor of the journal) |
The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway
Investigators found that interleukin-33 (IL-33)-ST2 signals selectively licensed memory T helper 2 (Th2) cells to induce allergic airway inflammation via production of IL-5 and that the p38 MAP kinase pathway was a central downstream target of IL-33-ST2 in memory Th2 cells. [Immunity] Abstract
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The Chromatin-Modifying Enzyme Ezh2 Is Critical for the Maintenance of Regulatory T Cell Identity after Activation
Scientists showed that CD28 co-stimulation, an extracellular cue intrinsically required for regulatory T (Treg) cell maintenance, induced the chromatin-modifying enzyme, Ezh2. Treg-specific ablation of Ezh2 resulted in spontaneous autoimmunity with reduced Foxp3+ cells in non-lymphoid tissues and impaired resolution of experimental autoimmune encephalomyelitis. [Immunity] Abstract
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Rational Development and Characterization of Humanized Anti-EGFR Variant III Chimeric Antigen Receptor T Cells for Glioblastoma
Investigators generated a panel of humanized single-chain variable fragments (scFvs) and tested their specificity and function as soluble proteins and in the form of chimeric antigen receptor (CAR)-transduced T cells. Lead candidate scFv was tested in vitro for its ability to direct CAR-transduced T cells to specifically lyse, proliferate, and secrete cytokines in response to antigen-bearing targets. [Sci Transl Med]
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Press Release
Normalization of CD4+ T Cell Metabolism Reverses Lupus
CD4+ T cells rely on glycolysis for inflammatory effector functions, but recent studies have shown that mitochondrial metabolism supports their chronic activation. Researchers show that both glycolysis and mitochondrial oxidative metabolism are elevated in CD4+ T cells from lupus-prone B6.Sle1.Sle2.Sle3 mice as compared to non-autoimmune controls. [Sci Transl Med] Abstract
Dendritic Cells Induce Th2-Mediated Airway Inflammatory Responses to House Dust Mite via DNA-Dependent Protein Kinase
Investigators demonstrate that pharmacological inhibition of DNA-dependent protein kinase (DNA-PK), as well as the specific deletion of DNA-PK in dendritic cells, attenuates the induction of allergic sensitization and Th2 immunity via a mechanism that involves the impaired presentation of mite antigens. [Nat Commun] Abstract
Defined TLR3-Specific Adjuvant that Induces NK and CTL Activation without Significant Cytokine Production In Vivo
Scientists created an RNA ligand for Toll-like receptor 3 (TLR3) with no ability to activate the RIG-I/MDA5 pathway. The activation of TLR3/TICAM-1 pathway by phosphorothioate ODN-guided dsRNA effectively induced natural killer (NK) and cytotoxic T cells in tumor-loaded mice, establishing antitumor immunity. [Nat Commun] Abstract
Self-Restrained B Cells Arise following Membrane IgE Expression
Scientists demonstrate a self-controlled membrane immunoglobulin E (mIgE)+ B cell stage. Primary or transfected mIgE+ cells relocate the B cell receptors into spontaneously internalized lipid rafts, lose mobility to chemokines, and change morphology. [Cell Rep] Full Article
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Press Release
Estrogen Regulates T Helper 17 Phenotype and Localization in Experimental Autoimmune Arthritis
Researchers investigated the effects of estrogen on interleukin-17-producing T helper (Th17) cells in experimental arthritis. They report that 17β-estradiol treatment results in an increase of Th17 cells in lymph nodes during the early phase of arthritis development, but a decrease of Th17 in joints during established arthritis. [Arthritis Res Ther] Abstract
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| | | SCIENCE NEWS |
Kineta to Present New, Positive Data for ShK-186 in Autoimmune Eye Diseases and in ANCA Vasculitis
Kineta, Inc. announced that new data from two separate studies for its lead compound, ShK-186, have been accepted for upcoming scientific conference presentations. [Press release from Kineta, Inc. discussing research to be presented at the 7th Ocular Diseases Drug Discovery Conference, San Diego and the 17th International ANCA and Vasculitis Workshop, London] Press Release
Celsion Corporation Presents Clinical and Preclinical Data for GEN-1 IL-12 Immunotherapy in Ovarian Cancer
Celsion Corporation presented clinical and preclinical data demonstrating the safety, biological activity and clinical benefits of GEN-1, its DNA-based immunotherapy, as a single agent in advanced platinum-resistant and recurrent ovarian cancer patients. [Press release from Celsion Corporation discussing research presented at the Molecular Medicine TRI-Conference, San Francisco] Press Release
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Presentation
From our sponsor: Free Nature Reviews Immunology poster – Immune Response to HIV. Request a copy.
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