Volume 7.05 | Feb 13

Immune Regulation News 7.05 February 13, 2015
Immune Regulation News
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Scientists Reveal Dual Role for Key T Cell Factor
When fighting chronic viral infections or cancers, a key division of the immune system, known as CD8 T cells, sometimes loses its ability to effectively fight foreign invaders. Scientists report that the shift is masterminded in part by NFAT, short for nuclear factor of activated T cells, and best known for its crucial role in getting CD8 T cells battle-ready. [Press release from La Jolla Institute for Allergy and Immunology discussing publication in Immunity] Press Release | Abstract | Graphical Abstract
Free Nature Reviews Immunology Poster: The Immune Response to HIV
PUBLICATIONS (Ranked by impact factor of the journal)
The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury
Scientists identified the nuclear alarmin, interleukin (IL)-33, as an important regulator of the innate immune response after CNS injury. IL-33 is released immediately after CNS injury from damaged oligodendrocytes, acting on local astrocytes and microglia to induce chemokines critical for monocyte recruitment. [Neuron] Abstract | Press Release

Immature Myeloid Cells Directly Contribute to Skin Tumor Development by Recruiting IL-17-Producing CD4+ T Cells
To identify the direct role of CD33+S100A9+ cells in tumor development, investigators used S100A9 transgenic mice to create the conditions for topical accumulation of these cells in the skin in the absence of infection or tissue damage. [J Exp Med] Abstract | Press Release

Imaging Regulatory T Cell Dynamics and ​CTLA4-Mediated Suppression of T Cell Priming
​Foxp3+ regulatory T cells (Tregs) are identified as two non-overlapping populations in the T-zone and follicular regions of the lymph node. In the T-zone, Tregs migrate more rapidly than conventional T cells (Tconv), extend longer processes and interact with resident dendritic cells and Tconv. [Nat Commun] Abstract

Suppression of Systemic Autoimmunity by the Innate Immune Adaptor STING
Investigators report that stimulator of interferon genes (STING) potently suppresses inflammation in a model of systemic lupus erythematosus. STING-deficient macrophages failed to express negative regulators of immune activation and thus were hyperresponsive to TLR ligands, producing abnormally high levels of proinflammatory cytokines. [Proc Natl Acad Sci USA] Abstract

PTEN Regulates Natural Killer Cell Trafficking In Vivo
Scientists used a natural killer (NK) cell-specific phosphatase and tensin homolog (PTEN)-deletion mouse model to define the ramifications of intrinsic NK cell PTEN loss in vivo. They investigated the ability of PTEN-deficient NK cells to traffic to a site of tumor challenge. [Proc Natl Acad Sci USA] Abstract

Heme Oxygenase-1 Regulates Myeloid Cell Trafficking in AKI
Researchers investigated whether heme oxygenase-1 expression, which is protective in ischemia-reperfusion injury, regulates trafficking of myeloid-derived immune cells in the kidney. [J Am Soc Nephrol]
Abstract | Press Release

Immunomodulation of Selective Naive T Cell Functions by p110δ Inactivation Improves the Outcome of Mismatched Cell Transplantation
In a mouse model of fully mismatched hematopoietic cell transplantation, scientists show that genetic inactivation of p110δ in T cells leads to milder graft versus host disease, whereas graft versus leukemia is preserved. [Cell Rep] Full Article | Graphical Abstract

Subdominant H60 Antigen-Specific CD8 T-Cell Response Precedes Dominant H4 Antigen-Specific Response during the Initial Phase of Allogenic Skin Graft Rejection
To understand the mechanism underlying the subdominance of H60 during allogeneic skin transplantation, scientists investigated the dynamics of the H60-specific CD8 T cells in B6 mice transplanted with allogeneic BALB.B tail skin. [Exp Mol Med] Full Article

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A New System for High-Throughput Cell Isolation Directly from Whole Blood
Potential Effector and Immunoregulatory Functions of Mast Cells in Mucosal Immunity
Investigators discuss evidence suggesting that mast cells can perform diverse effector and immunoregulatory roles that contribute to homeostasis or pathology in mucosal tissues. [Mucosal Immunol] Abstract

Understanding of Molecular Mechanisms in Natural Killer Cell Therapy
Although immune cells can suppress cancer cell growth, cancer cells can evade immune cell attack via immune escape mechanisms. The authors discuss the overall procedures and strategies of NK cell therapy against cancer. [Exp Mol Med] Full Article

Visit our reviews page to see a complete list of reviews in the immune regulation research field.

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IOmet Pharma Demonstrates Superior In Vivo PK/PD Properties in Pre-Clinical IDO, TDO and Dual IDO/TDO Cancer Immunotherapy Programs
IOmet Pharma presented data demonstrating superior pharmacokinetic/pharmacodynamic (PK/PD) properties in its pre-clinical IDO, TDO and IDO/TDO Dual Inhibitor programs. [Press release from IOmet Pharma discussing research presented at the Keystone Tumor Immunology Symposium, Banff] Press Release

Heat Biologics Presents Positive Preclinical Data on a Novel Approach to Combination Immunotherapy
Heat Biologics, Inc. announced data demonstrating the incorporation of T-cell costimulatory fusion proteins into Heat’s gp96-Ig vaccine platform. [Press release from Heat Biologics discussing research presented at the Keystone Tumor Immunology Symposium, Banff] Press Release

Biothera Immunotherapy Binds to Multiple Immune Cell Receptors to Kill Cancer
Biothera’s late stage cancer immunotherapy drug binds to multiple innate immune cell receptors to exert enhanced cytotoxicity against tumor cells. [Press release from Biothera discussing research presented at the Keystone Tumor Immunology Symposium, Banff] Press Release

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SPARC Consortium Provides $1.9 Million for Autoimmune Disease Research
The first grants from the Strategic Pharma-Academic Research Consortium for Translational Medicine will provide over $1.9 million to advance research on autoimmune disease at several medical research universities across the Midwest. [Indiana University School of Medicine] Press Release

Juno Therapeutics Establishes Manufacturing Presence in Washington State
Juno Therapeutics, Inc. announced that it has entered into a lease agreement for a facility in Bothell, Washington to manufacture the company’s cell therapy products. [Juno Therapeutics, Inc.] Press Release

Panacea Pharmaceuticals Engages Accelovance for Clinical Development of Its Novel Nanoparticle-Based Therapeutic Cancer Vaccine
Panacea Pharmaceuticals, Inc. and Accelovance Inc. announced the establishment of a clinical development services agreement to develop and advance Panacea’s oncology immunotherapy pipeline. [Panacea Pharmaceuticals, Inc. (PR Newswire Association LLC)] Press Release

Advaxis Forms Clinical Trial Collaboration with Incyte to Evaluate Investigational Combination of Two Novel Cancer Immunotherapies for Early Stage Cervical Cancer
Advaxis, Inc. has entered into a clinical trial collaboration agreement with Incyte Corporation to evaluate the combination of Advaxis’s Lm-LLO cancer immunotherapy, ADXS-HPV, with Incyte’s investigational oral indoleamine 2,3-dioxygenase 1 inhibitor, epacadostat. [Advaxis, Inc.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Keystone Symposium – T Cells: Regulation and Effector Function
March 29-April 3, 2015
Snowbird, United States

NEW International Congress of Mucosal Immunology (ICMI) 2015
July 14-18, 2015
Berlin, Germany

Visit our events page to see a complete list of events in the immune regulation community.
NEW Postdoctoral Associate – Oligonucleotide Aptamer-Based Compounds to Protect Tumor Vaccine-Induced Immune Cells (University of Miami)

Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Assistant/Associate Professor – Gastroenterology (North Carolina State University College of Veterinary Medicine)

Postdoctoral Position – Immunology Animal Models (The Technical University of Denmark)

Postdoctoral Position – Inflammatory Bowel Disease (The Technical University of Denmark)

Postdoctoral Fellowship – CNS Inflammation (Rutgers University)

Senior Scientist – Immuno-Oncology (Merus B.V.)

Postdoctoral Position – HIV and Ebolavirus (University of Missouri)

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