Inflammation-Induced Disruption of SCS Macrophages Impairs B Cell Responses to Secondary Infection
Investigators show that infection and inflammation disrupt the organization of subcapsular sinus (SCS) macrophages in a manner that involves the migration of mature dendritic cells to the lymph node. This disrupted organization reduces the capacity of SCS macrophages to retain and present antigen in a subsequent secondary infection, resulting in diminished B cell responses. [Science] Abstract
Class-Switched Memory B Cells Remodel BCRs within Secondary Germinal Centers
The integrated specificity and function of individual memory B cell progeny revealed ongoing evolution of polyclonal antibody specificities through germinal center (GC)-specific transcriptional activity. Scientists demonstrate that vaccine boosts reactivate a cyclic program of GC function in class-switched memory B cells to remodel existing antibody specificities and enhance durable immunological protection. [Nat Immunol] Abstract|Press Release
FOXP3+ Regulatory T Cell Development and Function Require Histone/Protein Deacetylase 3
Scientists determined that histone/protein acetyltransferases and histone/protein deacetylase (HDAC)3 mediates both the development and function of the two main Treg subsets, thymus-derived Tregs and induced Tregs. They determined that HDAC3 and FOXP3 physically interact and that HDAC3 expression markedly reduces Il2 promoter activity. [J Clin Invest] Full Article
Targeting Cell Surface TLR7 for Therapeutic Intervention in Autoimmune Diseases
Investigators show that Toll-like receptor 7 (TLR7) is present on the cell surface of immune cells and that TLR7 responses can be inhibited by an anti-TLR7 antibody. TLR7 responses in dendritic cells, macrophages and B cells are all inhibited by the anti-TLR7 antibody. [Nat Commun] Abstract
B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke
The authors tested the hypothesis that a B-lymphocyte response to stroke could contribute to the onset of dementia. They discovered that, in mouse models, activated B-lymphocytes infiltrate infarcted tissue in the weeks after stroke. B-lymphocytes undergo isotype switching, and IgM, IgG, and IgA antibodies are found in the neuropil adjacent to the lesion. [J Neurosci] Abstract|Press Release
Soligenix Announces Presentation and Poster
Soligenix, Inc. announced that it will be presenting preclinical data from two biodefense programs. [Press release from Soligenix, Inc. discussing research to be presented at the 2015 American Society of Microbiology (ASM) Biodefense and Emerging Diseases Research Meeting, Washington, DC] Press Release
Manchester to Lead Project for Better Lupus Treatment
The University of Manchester is to lead a new £5.1 million consortium of universities and industry partners in a project aimed at eliminating the ‘trial and error’ approach to the treatment of lupus. [University of Manchester] Press Release
Penn Medicine’s New Immunotherapy Study Will Pit PD-1 Inhibitor against Advanced Lung Cancer
Penn Medicine researchers have begun a new immunotherapy trial with the checkpoint inhibitor known as pembrolizumab in patients with oligometastatic lung cancer who have completed conventional treatments and are considered free of active disease but remain at a high risk for recurrence. [The University of Pennsylvania] Press Release
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