Volume 7.01 | Jan 16

Immune Regulation News 7.01 January 16, 2015
Immune Regulation News
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A Critical Role for Transcription Factor Smad4 in T Cell Function that Is Independent of Transforming Growth Factor β Receptor Signaling
Scientists demonstrate an essential role for Smad4 in promoting T cell function during autoimmunity and anti-tumor immunity. Smad4 deletion rescued the lethal autoimmunity resulting from transforming growth factor-beta receptor deletion and compromised T-cell-mediated tumor rejection. [Immunity] Abstract
Free Poster: Quick Reference for Mouse Immune Cell Frequencies and Percentages
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Myeloid Cell-Derived Reactive Oxygen Species Externally Regulate the Proliferation of Myeloid Progenitors in Emergency Granulopoiesis
Scientists found that reactive oxygen species (ROS) concentrations in the bone marrow (BM) were elevated during acute infection in a phagocytic NADPH oxidase-dependent manner in myeloid cells. Inflammation-induced ROS production in the BM played a critical role in myeloid progenitor expansion during emergency granulopoiesis. [Immunity] Abstract | Graphical Abstract

Selective NFAT Targeting in T Cells Ameliorates GvHD while Maintaining Antitumor Activity
Investigators explored the specific contribution of individual nuclear factor of activated T cells (NFAT) factors in donor T cells in animal models of graft-versus-host disease (GvHD) and graft-versus-leukemia. Ablation of NFAT1, NFAT2, or a combination of both resulted in ameliorated GvHD, due to reduced proliferation, target tissue homing, and impaired effector function of allogenic donor T cells. [Proc Natl Acad Sci USA] Abstract

Autophagy-Independent Functions of UVRAG Are Essential for Peripheral Naïve T-Cell Homeostasis
Scientists generated T-cell-specific UV radiation resistance-associated gene (UVRAG)-deficient mice that lacked UVRAG expression specifically in T cells. UVRAG-deficient T-cells exhibited normal mitochondrial clearance and activation-induced autophagy, suggesting that UVRAG has an autophagy-independent role that is critical for peripheral naive T-cell homeostatic proliferation. [Proc Natl Acad Sci USA] Abstract | Full Article

CD11b Is Protective in Complement-Mediated Immune Complex Glomerulonephritis
Researchers found experimental immune complex-mediated glomerulonephritis is associated with accumulation of M1 macrophages and CD4+ T cells in kidneys and functional renal insufficiency. [Kidney Int] Full Article

Interleukin (IL)-21 Promotes Intestinal IgA Response to Microbiota
Investigators found that intestinal immunoglobulin A (IgA) was impaired in mice deficient in IL-17 or IL-21 signaling. IL-21, but not IL-17, is able to augment B-cell differentiation to IgA+ cells as mediated by transforming growth factor β1 and accelerate IgA class switch recombination. [Mucosal Immunol] Abstract

Homeostatic Control of Memory Cell Progenitors in the Natural Killer Cell Lineage
Investigators show that memory natural killer (NK) cells predominantly arise from killer cell lectin-like receptor G1 (KLRG1)-negative NK cell progenitors, whereas KLRG1-positive NK cells have limited capacity for expansion during infection with mouse cytomegalovirus. [Cell Rep] Full Article | Graphical Abstract

Insulin-Like Growth Factor-1 Endues Monocytes with Immune Suppressive Ability to Inhibit Inflammation in the Intestine
Researchers investigated the mechanism by which insulin-like growth factor-1 (IGF1) modulates monocyte (Mo) properties to inhibit immune inflammation in the intestine. IGF1-primed Mos showed the immune suppressive effect on inhibiting the immune inflammation in the mouse colon. [Sci Rep] Full Article

ROR Inverse Agonist Suppresses Insulitis and Prevents Hyperglycemia in a Mouse Model of Type 1 Diabetes
To investigate the roles and therapeutic potential for targeting retinoic acid receptor-related orphan receptors (RORs) in type 1 diabetes, scientists administered SR1001, a selective RORα/γ inverse agonist, to non-obese diabetic mice. SR1001 reduced pro-inflammatory cytokine expression, particularly TH17-mediated cytokines, reduced autoantibody production, and increased the frequency of CD4+Foxp3+ T regulatory cells. [Endocrinology] Abstract | Full Article

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Regulation of CD4 T-Cell Differentiation and Inflammation by Repressive Histone Methylation
The authors review the role of repressive histone modifications in the differentiation and function of CD4+ T helper cells in health and disease. [Immunol Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the immune regulation research field.
Intrexon, ZIOPHARM and MD Anderson in Exclusive CAR T Pact
Intrexon Corporation and its oncology partner, ZIOPHARM Oncology, announced a broad exclusive licensing agreement with The University of Texas MD Anderson Cancer Center, including an exclusive sublicensing agreement through MD Anderson for intellectual property developed at the University of Minnesota for the development of non-viral adoptive cellular cancer immunotherapies. [The University of Texas MD Anderson Cancer Center] Press Release

New Approach, New Hope: State Investment Will Fast-Track Innovative Roswell Park Research in Ovarian Cancer
Researchers at Roswell Park Cancer Institute have received a prestigious grant of nearly $12 million from the New York State Stem Cell Science Program to develop new therapies for advanced ovarian cancer. Using an approach known as adoptive T-cell therapy, the Roswell Park team will take stem cells from patients’ blood, re-engineer them and infuse the reprogrammed cells back into those patients. [Roswell Park Cancer Institute] Press Release

Boehringer Ingelheim and Yale University Collaborate to Investigate Novel Immunotherapy Targets across Several Therapeutic Areas
Boehringer Ingelheim announced a collaboration with Yale University with the goal of researching novel therapeutic targets in the field of immune-modulation. [Boehringer Ingelheim GmbH] Press Release

Academia-Industry Alliance towards Autoimmune Disease
Monash University announced that it has signed a research collaboration agreement with Janssen-Cilag Pty Ltd. The collaboration, facilitated by Johnson & Johnson Innovation, Asia Pacific, will focus on ground-breaking research at Monash University to develop potential new medicines to treat autoimmune diseases and disorders. [Monash University] Press Release

Kymab Partners with Cancer Immunotherapy Expert on Anti-Cancer Therapeutics
Kymab and Dr. Stephen Gillies will collaborate in the development of new immunocytokine-based drugs that seek to exploit the synergistic potential of combining antibodies directed against immuno-oncology drug targets with the proven anti-tumor activity of selected cytokine molecules. [Kymab Ltd.] Press Release

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Nature Owner Merges with Publishing Giant
Consolidation is afoot in scientific publishing. Macmillan Science and Education, the London-based publisher of Nature and Scientific American, will merge with Berlin-based Springer Science+Business Media, one of the world’s largest science publishers. [Nature News] Editorial

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Immune Checkpoint Inhibitors
March 24-26, 2015
Boston, United States

Visit our events page to see a complete list of events in the immune regulation community.
NEW Postdoctoral Fellowship – CNS Inflammation (Rutgers University)

NEW Director (California Institute for Regenerative Medicine)

NEW Senior Scientist – Immuno-Oncology (Merus B.V.)

Postdoctoral Position – Immunology (Inserm)

Postdoctoral Position – HIV and Ebolavirus (University of Missouri)

Postdoctoral Position – Immunology (Hospital for Special Surgery)

Faculty Position – Immunology (Dana-Farber Cancer Institute and Harvard Medical School)

Postdoctoral Position – Immunology (The University of Alabama at Birmingham)

Postdoctoral Position – Immunology (Blood Research Institute, Blood Center of Wisconsin)

Product Manager Global Marketing – Autoimmunity (Thermo Fisher Scientific)

Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

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