Nanoparticles Target Anti-Inflammatory Drugs Where Needed
Researchers developed a system for precisely delivering anti-inflammatory drugs to immune cells gone out of control, while sparing their well-behaved counterparts. The system uses nanoparticles made of tiny bits of protein designed to bind to unique receptors found only on neutrophils, a type of immune cell engaged in detrimental acute and chronic inflammatory responses. [Press release from the University of Illinois at Chicago discussing online prepublication in Nature Nanotechnology]
Press Release|
Abstract
Central Memory CD8+ T Lymphocytes Mediate Lung Allograft Acceptance
Using a murine model, scientists found that costimulatory blockade-mediated lung allograft acceptance depended on the rapid infiltration of the graft by central memory CD8+ T cells (CD44hiCD62LhiCCR7+). Chemokine receptor signaling and alloantigen recognition were required for trafficking of these memory T cells to lung allografts. [J Clin Invest]
Full Article|Press Release
Foxp3+ T Cells Inhibit Antitumor Immune Memory Modulated by mTOR Inhibition
Inhibition of mTOR signaling enhances antitumor memory lymphocytes. However, pharmacologic mTOR inhibition also enhances regulatory T cell (Treg) activity. To counter this effect, Treg-control was added to mTOR inhibition in preclinical models. [Cancer Res]
Abstract
Regulation of Immune Responses by Extracellular Vesicles
Given the tremendous therapeutic potential of extracellular vesicles, this review focuses on their role in modulating immune responses, as well as their potential therapeutic applications. [Nat Rev Immunol]
Abstract
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INDUSTRY NEWS
THYMISTEM Researches Stem Cell Therapies for Damaged Immune Systems
Studies show that transplanting thymus cells into patients can be an effective way to repair and restore the immune system; however the lack of a source for these specialized cells represents a major barrier. In the previous studies, scientists used cells from newborn babies that had been removed as a normal part of heart surgery. Cells from adult donors are shown not to have the same effect. The THYMISTEM team seeks to overcome this by finding new methods of producing thymus stem cells in the lab as an alternative source of cells for therapy. [European Commission]
Press Release
ImmunoCellular Therapeutics Receives Orphan Drug Status for ICT-107 in Glioblastoma in the European Union
ImmunoCellular Therapeutics, Ltd. announced that the European Medicines Agency has granted orphan drug designation for ICT-107 for the treatment of patients with glioblastoma. ICT-107 is an intradermally administered autologous vaccine consisting of the patient’s dendritic cells pulsed with six synthetic tumor-associated antigens: AIM-2, MAGE-1, TRP-2, gp100, HER-2, IL-13Rα2. [ImmunoCellular Therapeutics, Ltd.]
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