Volume 6.03 | Jan 31

Immune Regulation News 6.03 January 31, 2014
Immune Regulation News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
Cell Therapy News on Facebook  Immune Regulation News on Twitter
Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium
Researchers report that three distinct phagocyte subsets play highly coordinated roles in bacterial urinary tract infection. Ly6C macrophages acted as tissue-resident sentinels that attracted circulating neutrophils and Ly6C+ macrophages. [Cell] Abstract | Graphical Abstract
New EasySep™ 15-Minute Mouse Cell Isolation Kits - Calculate Time Savings
PUBLICATIONS (Ranked by impact factor of the journal)
The Transcriptional Regulator Aire Coopts the Repressive ATF7ip-MBD1 Complex for the Induction of Immunotolerance
Mbd1−/− mice developed pathological autoimmunity and had a defect in Aire-dependent thymic expression of genes encoding tissue-specific antigens, which underscores the importance of Aire’s interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance. [Nat Immunol] Abstract

The Unfolded-Protein-Response Sensor IRE-1α Regulates the Function of CD8α+ Dendritic Cells
Investigators found that dendritic cells constitutively activated the unfolded protein response sensor IRE-1α and its target, the transcription factor XBP-1, in the absence of endoplasmic reticulum stress. [Nat Immunol] Abstract

The Transcription Factor IRF8 Activates Integrin-Mediated TGF-β Signaling and Promotes Neuroinflammation
By studying the role of interferon regulatory factor 8 (IRF8) in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, scientists found that Irf8−/− mice are resistant to EAE. Expression of IRF8 in antigen-presenting cells such as macrophages, dendritic cells, and microglia, but not in T cells, facilitated disease onset and progression through multiple pathways. [Immunity] Abstract | Graphical Abstract

Oral Tolerance Can Be Established via Gap Junction Transfer of Fed Antigens from CX3CR1+ Macrophages to CD103+ Dendritic Cells
Researchers showed an unanticipated division of labor among antigen-presenting cells for the establishment of oral tolerance. Chemokine receptor CX3CR1+ macrophages were found to take up soluble fed antigens and quickly transfer them to CD103+ dendritic cells. [Immunity] Abstract | Graphical Abstract

In Vitro Membrane Reconstitution of the T-Cell Receptor Proximal Signaling Network
Scientists reconstituted the T-cell receptor phosphorylation signaling network using purified enzymes on liposomes, recapitulating the membrane environment in which they normally interact. [Nat Struct Mol Biol] Abstract

Intramuscular Therapeutic Vaccination Targeting HPV16 Induces T Cell Responses that Localize in Mucosal Lesions
The authors report marked immunologic changes in the target lesion microenvironment after intramuscular therapeutic vaccination targeting human papillomavirus serotype 16 (HPV16) E6/E7 antigens, in subjects with cervical intraepithelial neoplasias who had modest detectable responses in circulating T lymphocytes. [Sci Transl Med] Abstract | Press Release

PTPN2 Attenuates T-Cell Lymphopenia-Induced Proliferation
Researchers showed that protein tyrosine phosphatase N2 (PTPN2) is elevated in naive T cells leaving the thymus to restrict homoeostatic T-cell proliferation and prevent excess responses to self-antigens in the periphery. [Nat Commun] Abstract

Mst1/Mst2 Regulate Development and Function of Regulatory T Cells through Modulation of Foxo1/Foxo3 Stability in Autoimmune Disease
Investigators report that Mst1 regulates Foxp3 expression and regulatory T cell (Treg) development/function and inhibits autoimmunity through modulating Foxo1 and Foxo3 stability. They found that Mst1 deficiency impairs Foxp3 expression and Treg development and function in mice. [J Immunol] Abstract

LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct Pathways
The authors made transgenic mice with enforced expression of Lmo2 in T-cells by the CD2 promoter/enhancer. These transgenic mice developed highly penetrant T-ALL by two distinct patterns of gene expression: one in which there was concordant activation of Lyl1, Hhex, and Mycn or alternatively, with Notch1 target gene activation. [PLoS One] Full Article

Subscribe to our sister publications: Human Immunology News and Immunology of Infectious Disease News!

Got Cells? Rare progenitor and immune cells ready for your research.
Homeostatic Control of Regulatory T Cell Diversity
The authors highlight how differing local milieu might drive context-specific regulatory T cell function and restoration of immune homeostasis, and how dysregulation of these processes can precipitate disease. [Nat Rev Immunol] Abstract

The New Normal: Immunomodulatory Agents against Sepsis Immune Suppression
Recent studies from animal sepsis models and patient samples suggest that cytokines such as interleukin-7 (IL-7), IL-15, granulocyte macrophage colony-stimulating factor, as well as co-inhibitory molecule blockade, such as anti-programmed cell death receptor-1 and anti-B and T lymphocyte attenuator, may have utility in alleviating the clinical morbidity associated with sustained sepsis. This review discusses some of these novel immunomodulatory agents and evaluates their potential use as therapeutics. [Trends Mol Med] Abstract

Visit our reviews page to see a complete list of reviews in the immune regulation field.
Quest PharmaTech Announces Third Combinatorial Immunotherapy Clinical Trial for Oregovomab with a TLR3 agonist, Hiltonol®
Quest PharmaTech Inc. announced that it has entered into a license agreement with U.S. based Oncovir, Inc. to evaluate the clinical utility of combining Quest’s antibody immunotherapy technology with Oncovir’s immune activator, Hiltonol®, in a twenty patient ovarian cancer Phase II clinical trial. [Quest PharmaTech Inc.]
Press Release

Kiadis Pharma Initiates Collaboration for Personalized Immunotherapies Using ATIR™ with Technische Universität München within Munich Biotech Cluster
Kiadis Pharma B.V. announced that it has initiated a collaboration to identify and characterize leukemia-specific T-cells in Kiadis Pharma’s lead product ATIR™ that would be responsible for the Graft-versus-Leukemia effect of the T-cell immunotherapy product. [Kiadis Pharma B.V.] Press Release

Medigene Acquires Trianta Immunotherapies
Medigene AG has acquired Trianta Immunotherapies GmbH, a spin-off of the Helmholtz Zentrum München. Trianta is developing three complementary immunotherapy platforms with programs in clinical development to treat various tumor types. [Medigene AG] Press Release

From our sponsor: Free human hematopoietic progenitors wallchart. Request your copy.
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Imaging in 2020: 2014 Conference
September 21-25, 2014
Jackson Hole, United States

Visit our events page to see a complete list of events in the immune regulation community.
NEW Principal Investigator – Inflammation Research (Northwestern University)

NEW Assistant Professor – Development of Novel Biologicals for Immune-based Disorders (Leiden Academic Centre For Drug Research)

Fellowship – Blockade of Immune Checkpoints to Increase the Efficacy of HER2 Vaccine (University of Turin)

Postdoctoral Position – Cell Signaling in the Immune System (Baylor Institute for Immunology Research)

Immunology Research Associate Position (Shanghai Jiaotong University School of Medicine)

Postdoctoral Position – Epigenetic Regulation of Interleukin-12 Family Members (Université Libre de Bruxelles)

Postdoctoral Position – Molecular/Cellular Immunology (National Institute of Allergy and Infectious Disease/National Institutes of Health)

PhD Position – Biology/Immunology (Saarland University)

Postdoctoral Position – Immunology/Cardiovascular Disease (Medical University of Innsbruck)

PhD Research Position – Molecular and Cellular Mechanisms of Immune Tolerance and Autoimmunity (Weizmann Institute of Science)

Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Immune Regulation News? Click here to submit!

Comments or Suggestions? Submit your feedback here.
Learn more about Immune Regulation News: Archives | Events | Contact Us