Volume 5.48 | Dec 13

Immune Regulation News 5.48 December 13, 2013
Pulmonary Cell News
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New Insights into the Immune System of the Gastrointestinal Tract
Lymphotoxin regulates the immune system of the digestive tract, which is made up of immune cells, immunoglobulins as well as intestinal bacteria. Scientists discovered how this complex interaction functions and how lymphotoxin controls the production of immunoglobulins in the gut. [Press release from Helmholtz Zentrum München discussing online prepublication in Science] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Two Waves of Distinct Hematopoietic Progenitor Cells Colonize the Fetal Thymus
Scientists found that thymopoiesis was initiated by a first wave of T cell lineage-restricted progenitor cells with limited capacity for population expansion but accelerated differentiation into mature T cells. [Nat Immunol] Abstract

Regulatory T Cell Proliferative Potential Is Impaired in Human Autoimmune Disease
Investigators report that proliferation of regulatory T cells after T cell receptor stimulation is impaired in subjects with relapsing-remitting multiple sclerosis because of altered interleukin-2 (IL-2) secretion and IL-2 receptor-signal transducer and activator of transcription 5 signaling. [Nat Med] Abstract

Therapeutic Activation of Macrophages and Microglia to Suppress Brain Tumor-Initiating Cells
Scientists examined whether the microglia and macrophages that are abundant in gliomas alter brain tumor initiating cell (BTIC) growth. They found that microglia derived from non-glioma human subjects markedly mitigated the sphere-forming capacity of glioma patient-derived BTICs in culture by inducing the expression of genes that control cell cycle arrest and differentiation. [Nat Neurosci] Abstract | Press Release

Diverting T Helper Cell Trafficking through Increased Plasticity Attenuates Autoimmune Encephalomyelitis
Investigators used an autoimmune encephalomyelitis model and found that Th17 cells deficient in the transcription factor BCL11B upregulated the Th2-associated proteins GATA3 and IL-4 without decreasing RAR-related orphan receptor γ, IL-17, and GM-CSF levels. [J Clin Invest] Full Article

CD4+ T Cells from IPEX Patients Convert into Functional and Stable Regulatory T Cells by FOXP3 Gene Transfer
The authors showed that when CD4+ T cells are converted into regulatory T cells after lentivirus-mediated forkhead box P3 (FOXP3) gene transfer, the resulting CD4FOXP3 T cell population displays stable phenotype and suppressive function, especially when naïve T cells are converted. [Sci Transl Med] Abstract

Genetic Disruption of CD8+ Treg Activity Enhances the Immune Response to Viral Infection
Researchers studied a cellular interaction that may enhance the antiviral immune response and constrain immunopathology. They analyzed the contribution of Qa-1-restricted CD8+ regulatory T (Treg) cells to antiviral immunity after infection by lymphocytic choriomeningitis virus. [Proc Natl Acad Sci USA] Abstract

Gene Trap Mice Reveal an Essential Function of Dusp16/MKP-7 in Perinatal Survival and Regulation of TLR-Induced Cytokine Production
Scientists investigated the function of dual specificity phosphatase 16 (Dusp16)/MKP-7 in the innate immune system. The Dusp16 isoforms A1 and B1 were inducibly expressed in macrophages and DC following TLR stimulation. [J Biol Chem]
| Full Article
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Follicular Dendritic Cells: Origin, Phenotype, and Function in Health and Disease
Recent studies have provided fundamental insights into the multiple functions of follicular dendritic cells (FDCs) in both physiological and pathophysiological contexts and into their origin. The authors review these findings, and discuss current concepts related to FDC histogenesis both in lymphoid organs and in inflammatory lymphoneogenesis. [Trends Immunol] Abstract

Foxp3+ Treg Cells in Humoral Immunity
Scientists discuss the effects of regulatory T (Treg) cells on humoral immunity and the mechanisms by which they exert their regulatory function. [Int Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the immune regulation field.
Adaptimmune Announces Interim Results from a Phase I/II Trial of Engineered T Cells Targeting Cancer Testis Antigens in Multiple Myeloma
Adaptimmune announced the release of interim results from a Phase I/II clinical trial using patients’ own T cells that have been genetically altered to attack multiple myeloma cells. [Press release from Adaptimmune discussing research presented at the 55th Annual Meeting of the American Society of Hematology (ASH), New Orleans] Press Release

MacroGenics Announces Presentation of Pre-Clinical Data on DART(R) Molecule Targeting CD123-Positive Leukemic Stem Cells
MacroGenics, Inc. announced the presentation of pre-clinical data for its proprietary DART® molecule, MGD006. These data demonstrate activity of MGD006, a bispecific molecule that redirects T cells against CD123-positive leukemic cells and results in the clearance of acute myeloid leukemia blasts in vitro and in vivo. [Press release from MacroGenics, Inc. discussing research presented at the 55th Annual Meeting of the American Society of Hematology (ASH), New Orleans] Press Release

Novartis Highlights Research on Investigational, Personalized T Cell Therapy CTL019 in Patients with Forms of Acute and Chronic Leukemia
Novartis is highlighting new research from members of the faculty at the University of Pennsylvania’s Perelman School of Medicine on the investigational chimeric antigen receptor therapy, CTL019. [Press release from Novartis AG discussing research presented at the 55th Annual Meeting of the American Society of Hematology (ASH), New Orleans] Press Release

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CEO Dr. Joseph Kim to Discuss Inovio’s Innovative Approach to Treating Cervical Cancer in an Expert Panel
Inovio Pharmaceuticals, Inc. announced that Dr. J. Joseph Kim, President and CEO, has been invited to participate on an expert panel titled, Ovarian & Cervical Cancer – Evaluating the Role of Immunotherapy Exploring Three Approaches – Dendritic Cells, DNA Plasmids & Liposomal Delivery. Dr. Kim will discuss Inovio’s DNA immunotherapy VGX-3100, which was designed to treat cervical pre-cancers and cancers, head & neck cancers, and anogenital cancers caused by human papillomavirus. [Inovio Pharmaceuticals, Inc.] Press Release

LifeSci Advisors Initiates Coverage of Immune Pharmaceuticals
LifeSci Advisors, LLC announced that it has initiated coverage of Immune Pharmaceuticals Inc., a clinical stage biopharmaceutical company focused on developing antibody therapeutics for inflammatory diseases and cancer. Immune Pharmaceuticals’ lead development program is bertilimumab, currently in Phase II clinical trials for treatment of ulcerative colitis, Crohn’s disease and bullous pemphigoid, an orphan, autoimmune dermatological condition. [Marketwire L.P.] Press Release
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NEW ThymOz International Conference: An International Workshop on T Lymphocytes
April 2-6, 2014
Heron Island, Australia

Visit our events page to see a complete list of events in the immune regulation community.
NEW Postdoctoral Position – Food Induced Modulation of the Intestinal Immune Barrier (TI Food and Nutrition)

Chief Medical Officer – Novel Therapeutics in Oncology and Autoimmune Disease (Immunomedics, Inc.)

Clinical MD – Clinical Development Program for Oncology and Autoimmune Diseases (Immunomedics, Inc.)

Postdoctoral Research Position – Immunology (SANOFI R&D)

PhD Studentship – Systems Biology and Lymphocyte Activation (University of Oxford)

Research Studentship – Imaging Membrane Lipid in Activating T Cells (King’s College London)

PhD Research Position – Molecular and Cellular Mechanisms of Immune Tolerance and Autoimmunity (Weizmann Institute of Science)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

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