Volume 5.34 | Sep 6

Immune Regulation News 5.34 September 6, 2013
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
IL-27 Acts on DCs to Suppress the T Cell Response and Autoimmunity by Inducing Expression of the Immunoregulatory Molecule CD39
Investigators found that interleukin 27 (IL-27) signaling in mouse dendritic cells (DCs) limited the generation of effector cells of the TH1 and TH17 subsets of helper T cells and the development of experimental autoimmune encephalomyelitis. [Nat Immunol] Abstract
Free Sample: The Only Kit to Isolate Th17 Cells Without Cell Activation
 
PUBLICATIONS (Ranked by impact factor of the journal)
Myeloid-Derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor C-Terminal Binding Protein-2
The authors examined the interaction between myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) in patients with ovarian carcinoma and showed that MDSCs inhibited T cell activation and enhanced CSC gene expression, sphere formation, and cancer metastasis. [Immunity]
Abstract
| Graphical Abstract | Press Release

The TACI Receptor Regulates T-Cell-Independent Marginal Zone B Cell Responses through Innate Activation-Induced Cell Death
Scientists showed that marginal zone (MZ) B cells undergo activation-induced cell death in response to TLR4 activation in vivo. The transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) receptor and Toll-like receptor 4 cooperate to upregulate expression of both FasL and Fas on MZ B cells and also to repress inhibitors of Fas-induced apoptosis signaling. [Immunity] Abstract | Press Release

CD4+ T Cells Are Trigger and Target of the Glucocorticoid Response that Prevents Lethal Immunopathology in Toxoplasma Infection
Researchers showed that glucocorticoids are induced during acute Toxoplasma gondii infection and directly control the T cell response to the parasite. [J Exp Med] Abstract

Quantal and Graded Stimulation of B Lymphocytes as Alternative Strategies for Regulating Adaptive Immune Responses
Investigators applied quantitative methods to study B-cell responses in vitro. Their results reveal that B cells stimulated through two Toll-like receptors require minimal external direction to undergo the basic pattern typical of immunity. [Nat Commun] Full Article

Macrophages Mediate Gemcitabine Resistance of Pancreatic Adenocarcinoma by Upregulating Cytidine Deaminase
The authors showed for the first time that tumor-associated macrophages (TAMs) can induce chemoresistance of pancreatic ductal adenocarcinoma by reducing gemcitabine-induced apoptosis. Macrophages co-cultured with cancer cells or TAM-conditioned medium significantly reduced apoptosis and activation of the caspase-3 pathway during gemcitabine treatment. [Oncogene] Abstract

Distinct Molecular Signature of Human Skin Langerhans Cells Denotes Critical Differences in Cutaneous Dendritic Cell Immune Regulation
Genome-wide comparison of the transcriptional profiles of human skin migratory CD1a+ Langerhans cells (LCs) and CD11c+ dermal dendritic cells (DDCs) demonstrated significant differences between these ‘dendritic cell’ types, including preferential expression of 625 genes in LCs and 914 genes in DDC. Analysis of the temporal regulation of molecular networks activated after stimulation with TNF-α confirmed the unique molecular signature of LCs. [J Invest Dermatol] Abstract

Lectin-Like Receptor Ly49s3 on Dendritic Cells Contributes to the Differentiation of Regulatory T Cells in the Rat Thymus
The Hirosaki hairless rat (HHR), derived from the Sprague-Dawley rat, was shown to have decreased peripheral lymphocyte number, small thymus, and leukocyte infiltration in its dermis. In the HHR thymus, the medulla was underdeveloped and regulatory T cells number was decreased. [J Immunol] Abstract

CD47 Plays a Critical Role in T-Cell Recruitment by Regulation of LFA-1 and VLA-4 Integrin Adhesive Functions
Researchers tested the hypothesis that CD47 regulates adhesive functions of T-cell α4β1 (VLA-4) and αLβ2 (LFA-1) in in vivo and in vitro models of inflammation. [Mol Biol Cell] Abstract

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A New System for High-Throughput Cell Isolation Directly from Whole Blood
 
REVIEWS
BamHI-A Rightward Frame 1, an Epstein-Barr Virus-Encoded Oncogene and Immune Modulator
The authors discuss recent insights on the regulation of BamHI-A rightward frame 1 expression and aspects of structure-function relating to its oncogenic and immune suppressive properties. [Rev Med Virol]
Full Article


Cellular Stress Response and Innate Immune Signaling: Integrating Pathways in Host Defense and Inflammation
The review describes the regulation of innate immune cell activation by cell stress pathways, present detailed descriptions of the types of stress response proteins and their crosstalk with immune signaling intermediates that are essential in host defense, and illustrate the relevance of these interactions in diseases characteristic of aberrant immune responses, such as chronic inflammatory diseases, autoimmune disorders, and cancer. [J Leukoc Biol] Abstract

Review Series on Immune Responses in Neurodegenerative Diseases: Oligodendrocyte-Microglia Cross-Talk in the CNS
The authors review evidence that oligodendrocytes have strong immune functions, express a wide variety of innate immune receptors, and produce and respond to chemokines and cytokines that modulate immune responses in the central nervous system (CNS). [Immunology] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the immune regulation field.
 
INDUSTRY NEWS
TNI BioTech, Inc. Signs Manufacturing Agreement for IRT-103[TM] LDN
TNI BioTech, Inc. (TNIB) and Laboratorios Ramos announced that they entered a manufacturing and supply agreement for the production of Low Dose Naltrexone (LDN) for commercial use. This agreement enables TNIB to focus on the development and commercialization of therapeutic treatments for cancer, HIV/AIDS and autoimmune diseases by combating these fatal diseases through the activation and modulation of the body’s immune system. [TNI BioTech, Inc.] Press Release

Four UCLA Stem Cell Researchers Receive CIRM Early Translational Grants
Four researchers from University of California, Los Angeles’ (UCLA’s) Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have received Early Translational Research Awards totaling approximately $13 million from the California Institute for Regenerative Medicine (CIRM), the state’s stem cell agency. [University of California, Los Angeles] Press Release

Immune Design Appoints Richard T. Kenney, M.D., Chief Medical Officer
Immune Design announced the appointment of Richard T. Kenney, M.D., FACP, as its Chief Medical Officer. A distinguished leader in vaccine development, Dr. Kenney brings extensive experience in the research, clinical, and regulatory fields from the biopharmaceutical industry, public health, and governmental environments. [GlobeNewswire, Inc.] Press Release

From our sponsor: Free Nature Reviews Immunology poster – Immune Response to HIV. Request a copy.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 8th World Immune Regulation Meeting
March 19-22, 2014
Davos, Switzerland

Visit our events page to see a complete list of events in the immune regulation community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellowships – Immunology (Trinity College Dublin)

PhD/Postdoctoral Positions – Quantitative T-Cell Immunology (University of Leeds)

Postdoctoral Position – Identification of Novel Components of the Nlrp10 Pathway and their Effects on Dendritic Cell Mediated Immune Function

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Scientist – Immune System Signaling (University of Pennsylvania)

Postdoctoral Position – Innate Immune Signaling in the Developing Intestine (University of Connecticut Health Center)

Postdoctoral Fellowship – Immunology (Johns Hopkins University School of Medicine)

PhD Research Position – Molecular and Cellular Mechanisms of Immune Tolerance and Autoimmunity (Weizmann Institute of Science)


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