Volume 4.41 | Oct 26

Immune Regulation News 4.41 October 26, 2012
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
The CD46-Jagged1 Interaction Is Critical for Human TH1 Immunity
CD4+ T cells from CD46-deficient patients and patients with hypomorphic mutations in the gene encoding Jagged1 failed to mount appropriate T helper type 1 (TH1) responses in vitro and in vivo, which suggested that CD46-Jagged1 crosstalk is responsible for the recurrent infections in subpopulations of these patients. [Nat Immunol] Abstract

Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
PUBLICATIONS (Ranked by impact factor of the journal)

Control of RelB during Dendritic Cell Activation Integrates Canonical and Noncanonical NF-κB Pathways
Researchers report that RelB promoted dendritic cell activation not as the expected RelB-p52 effector of the noncanonical NF-κB pathway, but as a RelB-p50 dimer regulated by canonical IκBs, IκBα and IκBε. [Nat Immunol] Abstract

Identification of Key Regulatory Pathways of Myeloid Differentiation Using an mESC-Based Karyotypically Normal Cell Model
Investigators showed that myeloid progenitors can be derived from embryonic stem cells (ESCs), immortalized, and applied to the study of the mechanisms underlying myeloid differentiation. The ESC-derived myeloid progenitors, when immortalized with estrogen-regulated Hoxb8 protein, demonstrate normal karyotyping, are genetically tractable, and can be differentiated into functional neutrophils. [Blood]
Abstract | Press Release

Intraperitoneal Influx of Neutrophils in Response to IL-33 Is Mast Cell Dependent
Findings revealed that interleukin-33 (IL-33) activates mast cells in vivo to recruit neutrophils, a mechanism dependent on IL-33R-expression on peritoneal mast cells. [Blood] Abstract

PI3K-PKB Hyperactivation Augments Human Plasmacytoid Dendritic Cell Development and Function
Researchers investigated the role of the PI3K-PKB-mTOR axis in human plasmacytoid dendritic cells development, survival and function. [Blood] Abstract

Microglial Repopulation Model Reveals a Robust Homeostatic Process for Replacing CNS Myeloid Cells
The authors report a model in which a niche for myeloid cells was created through microglia depletion. They showed that microglia-depleted brain regions of CD11b-HSVTK transgenic mice are repopulated with new Iba-1-positive cells within two weeks. The engrafted cells expressed high levels of CD45 and CCR2 and appeared in a wave-like pattern frequently associated with blood vessels, suggesting the engrafted cells were peripheral monocytes. [Proc Natl Acad Sci USA] Abstract | Press Release

T Cell Receptor/CARMA1/NF-κB Signaling Controls T-Helper (Th) 17 Differentiation
Using genetic mouse models that impede T-cell-nuclear factor κB (NF-κB) signaling either downstream of the T-cell receptor or of IκB kinase β, researchers demonstrated that NF-κB signaling controls not only survival and proliferation of activated T cells, but, if cell survival and cell-cycle progression are enabled, has an additional role in promoting completion of Th17 differentiation. [Proc Natl Acad Sci USA] Abstract

Adoptive Transfer of Autologous T Cells Improves T Cell Repertoire Diversity and Long Term B Cell Function in Pediatric Patients with Neuroblastoma
Researchers found that the infusion of activated T cells can improve immunologic function especially when given early after hematopoietic stem cell transplantation for children with high-risk neuroblastoma. [Clin Cancer Res] Abstract

HIV-1 gp120 Impairs the Induction of B Cell Responses by TLR9-Activated Plasmacytoid Dendritic Cells
Data showed that HIV type 1 (HIV-1) gp120 impairs plasmacytoid dendritic cell functions, including activation of B cell responses, implying that TLR9 ligands may not be good adjuvants to use in combination with envelope glycoprotein vaccines. [J Immunol] Abstract

In the Presence of IL-21 Human Cord Blood T Cells Differentiate to IL-10 Producing Th1 but Not Th17 or Th2 Cells
In umbilical cord blood, researchers demonstrated that interleukin (IL)-21 polarized naive CD4+ T cells into Th1 cells, producing IL-10, a key negative regulator during certain infections and autoimmunity. [Int Immunol] Abstract

Induction of M2-Like Macrophages in Recipient NOD-scid Mice by Allogeneic Donor CD4+CD25+ Regulatory T Cells
The effect of allogeneic donor CD4+CD25+ regulatory T cells (Tregs) on recipient mouse resident F4/80+macrophages was investigated using a mouse model in which allogeneic donor CD4+CD25+ Tregs were adoptively transferred into the peritoneal cavity of host NOD-scid mice. [Cell Mol Immunol] Abstract

Learn more about the new smartphone app for human blood cell frequencies

REVIEWS

Harnessing the Power of the Immune System to Target Cancer
In this review, researchers describe four of the most effective immunotherapeutic approaches currently used in the clinic: cancer vaccines, immunostimulatory agents, adoptive T cell therapy, and immune checkpoint blockade. [Annu Rev Med] Abstract

Defining the Nature of Human γδ T Cells: A Biographical Sketch of the Highly Empathetic
This review gives an overview of the latest insights revealing the unfolding story of human γδ T cells, providing a biographical sketch of these unique lymphocytes in an attempt to capture the essence of their fundamental nature and events that influence their life trajectory. [Cell Mol Immunol] Abstract

INDUSTRY NEWS

CEL-SCI Corporation Announces Results of Interim Review of Data from Its Ongoing Phase III Head and Neck Cancer Trial by Independent Data Monitoring Committee (IDMC)
CEL-SCI Corporation announced that an interim review of the safety data from its open label, randomized, controlled, pivotal Phase III study of Multikine (Leukocyte Interleukin, Injection) investigational immunotherapy by an IDMC raised no safety concerns. The IDMC also indicated that no safety signals were found that would call into question the benefit/risk of continuing the study. [CEL-SCI Corporation] Press Release

Association Establishes the AABB Center for Cellular Therapies
AABB (formerly the American Association of Blood Banks) has established the AABB Center for Cellular Therapies, a functional unit within AABB that will focus on activities designed to foster patient safety and responsible innovation in the cellular therapy and regenerative medicine field. [AABB] Press Release

The C4C Consortium Announces the Implementation of France’s First Ever Facility for the Industrialization of Cell Therapeutics and Presents the Five Drugs under Development for Use in Personalized Medicine
The C4C consortium announced the implementation of France’s first ever dedicated technical facility for the manufacture of cell therapy products. [Business Wire] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 2012 Annual Meeting of the Japanese Society for Immunology
December 5-7, 2012
Kobe, Japan

Visit our events page to see a complete list of events in the immune regulation community.
JOB OPPORTUNITIES

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)


Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)


Product Manager – Hematopoietic (STEMCELL Technologies, Inc.)

Product Quality Scientist (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cell Research (STEMCELL Technologies, Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies, Inc.)

Postdoctoral Position – Immunology (San Raffaele Scientific Institute)


Postdoctoral Positions – Immunity and Inflammation (CNRS & University of Toulouse, France)


Research Associate – Quality Assurance (University of California)

Postdoctoral & PhD Student Positions – NK Cell-Based Anti-Cancer Immunotherapies (Medical University of Vienna)

Research Fellowship in Immune Cell Biology (Imperial College London)

Postdoctoral Fellow – Department of Microbiology and Immunology (Penn State University College of Medicine)

Postdoctoral Position – Tumor Stem Cells (Cancer Institute of New Jersey)


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