Volume 4.34 | Sep 7

Immune Regulation News 4.34 September 7, 2012
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Lymphoid Priming in Human Bone Marrow Begins Before Expression of CD10 with Upregulation of L-Selectin
Expression of the cell-surface antigen CD10 has long been used to define the lymphoid commitment of human cells. Researchers report a unique lymphoid-primed population in human bone marrow that was generated from hematopoietic stem cells before onset of the expression of CD10 and commitment to the B cell lineage. [Nat Immunol] Abstract | Press Release

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The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens
Researchers showed that Puma cooperates with Bim to impose a thymic-deletion checkpoint to peripheral self-antigens and cemented the notion that defects in apoptosis alone are sufficient to cause autoimmune disease. [Immunity] Abstract | Press Release

γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response
The authors report that a noted B cell antigen, the algae protein phycoerythrin, is a murine and human γδ T cell antigen. Employing this specificity, they demonstrated that antigen recognition activated naive γδ T cells to make interleukin-17 and respond to cytokine signals that perpetuate the immune response. [Immunity] Abstract

T-Bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2
Researchers demonstrated that the development of T-bet+ regulatory T (Treg) cells that potently inhibit T helper 1 (Th1) cell responses was dependent on the transcription factor STAT1 and occurred directly in response to interferon-produced by effector T cells. [Immunity] Abstract

Hepatic Expression of HCV RNA-Dependent RNA Polymerase Triggers Innate Immune Signaling and Cytokine Production
Researchers showed that transient expression of Hepatitis C Virus RNA-dependent RNA polymerase, NS5B, in mouse liver and human hepatocytes resulted in production of small RNA species that activate innate immune signaling via TBK1-IRF3 and NF-B and induced cytokine production, including type I interferons and IL-6. [Mol Cell] Abstract

Regulation of Plasmacytoid Dendritic Cell Responses by PIR-B
Researchers showed that an inhibitory major histocompatibility complex class I receptor, paired immunoglobulin-like receptor (PIR)-B, suppressed Flt3-L-induced plasmacytoid dendritic cell (PDC) differentiation in bone marrow cells, as well as TLR9-mediated type I interferons-α production by PDCs, through the dephosphorylation of STAT1/2. [Blood] Abstract

Activated Mouse CD4+Foxp3 T Cells Facilitate Melanoma Metastasis via Qa-1-Dependent Suppression of NK-Cell Cytotoxicity
Scientists found that mitogen-activated CD4+Foxp3 T cells exhibited potent suppressor function on NK-cell proliferation and cytotoxicity in vitro, and notably facilitated B16 melanoma metastasis in vivo. [Cell Res]
Full Article

A Novel Mechanism for the Autonomous Termination of Pre-B Cell Receptor Expression via Induction of Lysosomal-Associated Protein Transmembrane 5
Researchers report that the pre-B cell receptor (pre-BCR) induces the prompt down-modulation of its own expression through induction of lysosomal-associated protein transmembrane 5 that promotes the lysosomal transport and degradation of the intracellular pre-BCR pool, and hence limits the supply of pre-BCR to the cell surface. [Mol Cell Biol] Abstract

CD64 Distinguishes Macrophages from Dendritic Cells in the Gut and Reveals the Th1-Inducing Role of Mesenteric Lymph Node Macrophages during Colitis
Dendritic cells (DCs) and monocyte-derived macrophages (MFs) are key components of intestinal immunity. However, the lack of surface markers differentiating MFs from DCs has hampered understanding of their respective functions. Researchers demonstrated that, using CD64 expression, MFs can be distinguished from DCs in the intestine of both mice and humans. [Eur J Immunol] Abstract

Immune Tolerance to Tumor Antigens Occurs in a Specialized Environment of the Spleen
Researchers found that CD11b+Gr-1intLy6Chi cells expand in the marginal zone of the spleen. Here, they alter the normal tissue cytoarchitecture and closely associate with memory CD8+ T cells, cross-presenting tumor antigens and causing their tolerization. [Cell Rep] Abstract

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Consortium Biology in Immunology: the Perspective from the Immunological Genome Project
Immunology is naturally suited to large-scale integrative and systems-level approaches, owing to the multicellular and adaptive nature of the cells it encompasses. The authors of this review discuss the value and drawbacks of this organization of research, in the context of the long-running ‘big science’ debate, and consider the opportunities that may exist for the immunology community. [Nat Rev Immunol] Abstract

Unconventional Recognition of Peptides by T Cells and the Implications for Autoimmunity
Researchers discuss unconventional peptide recognition by type B T cells and consider the implications for type 1 diabetes and other autoimmune diseases. [Nat Rev Immunol] Abstract

Cytokine-Induced Cytokine Production by Conventional and Innate Lymphoid Cells
This review discusses how cytokine-induced cytokine production may have broad significance in orchestrating innate responses to distinct infectious agents and in maintaining inflammatory responses after elimination of the inciting antigen. [Trends Immunol] Abstract


WuXi PharmaTech and Open Monoclonal Technology Announce OmniRat™ Antibody Collaboration
WuXi PharmaTech and Open Monoclonal Technology, Inc. (OMT) announced that they have entered into an agreement to use OMT’s OmniRat™ to develop therapeutic antibody candidates for commercialization by WuXi’s global customers. [Open Monoclonal Technology, Inc.] Press Release

Argos Therapeutics Expands Global Patent Protection
Argos Therapeutics Inc. announced it was recently granted two patents and one patent allowance from the United States Patent and Trademark Office and one patent allowance from the European Patent Office. These new patents and allowed patent applications cover compositions of matter and methods of use related to Argos´ proprietary immunotherapy technologies. [Argos Therapeutics, Inc.] Press Release

ImmuNext Enters into a Strategic Partnership with Janssen to Develop Novel Immunotherapies for the Treatment of Cancer
Under the terms of the agreement, ImmuNext will grant Janssen a worldwide, exclusive license to develop and commercialize therapeutics that antagonize the V-region immunoglobulin-containing suppressor of T-cell activation signaling pathway. [ImmuNext, Inc.] Press Release


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Center for Biologics Evaluation and Research (United States)

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Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Postdoctoral Position – Immunology (San Raffaele Scientific Institute)

Postdoctoral Positions – Immunity and Inflammation (CNRS & University of Toulouse, France)

Research Associate – Quality Assurance (University of California)

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