Volume 4.31 | Aug 17

Immune Regulation News 4.31 August 17, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells
Using various genetic approaches, researchers depleted CD11c+ dendritic cells (DCs) in mice and induced autoimmune CNS inflammation. Unexpectedly, mice lacking DCs developed aggravated disease compared to control mice. [Immunity] Abstract

PneumaCult™-ALI medium, optimized for bronchial epithelial cells
PUBLICATIONS (Ranked by impact factor of the journal)

Cytomegalovirus and Tumor Stress Surveillance by Binding of a Human γδ T Cell Antigen Receptor to Endothelial Protein C Receptor
Researchers found that the T cell antigen receptors of a human Vγ4Vδ5 clone directly bound endothelial protein C receptor, which allowed γδ T cells to recognize both endothelial cells targeted by cytomegalovirus and epithelial tumors. [Nat Immunol] Abstract

The CD100 Receptor Interacts with its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function
γδ T cells respond rapidly to keratinocyte damage, providing essential contributions to the skin wound healing process. The molecular interactions regulating their response are unknown. Researchers identified a role for interaction of plexin B2 with the CD100 receptor in epithelial repair. In vitro blocking of plexin B2 or CD100 inhibited T cell activation. [Immunity] Abstract

Dynamic T Cell-APC Interactions Sustain Chronic Inflammation in Atherosclerosis
Researchers found that antigen presentation by APCs to CD4+ T cells in the arterial wall causes local T cell activation and production of proinflammatory cytokines, which promote atherosclerosis by maintaining chronic inflammation and inducing foam cell formation. [J Clin Invest] Abstract | Press Release

B Cells from Patients with Chronic GvHD Are Activated and Primed for Survival via BAFF Mediated Pathways
Since BAFF increases murine B cell metabolism, survival, and maintains autoreactive B cell clones, the authors performed ex vivo analyses of peripheral B cells from 51 patients who either had or did not have active chronic GvHD and were greater than one year from the time of allogeneic hematopoietic stem cell transplantation. [Blood] Abstract | Press Release

Nucleic Acid-Containing Amyloid Fibrils Potently Induce Type I Interferon and Stimulate Systemic Autoimmunity
The authors report that nucleic acid-containing amyloid fibrils can potently activate plasmacytoid dendritic cells (pDCs) and enable type I IFN (IFN-I) production in response to self-DNA, self-RNA, and dead cell debris. pDCs can take up DNA-containing amyloid fibrils, which are retained in the early endosomes to activate TLR9, leading to high IFNα/β production. [Proc Natl Acad Sci USA] Abstract

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-Cell Pool Changes Observed in Mice with Aging
The authors present direct experimental evidence that mouse cytomegalovirus infection results in select T-cell subset changes associated with immune aging, namely the increase of relative and absolute counts of CD8 T-cells in the blood, with a decreased representation of the naïve and the increased representation of the effector memory blood CD8 T-cells. [PLoS Pathog] Full Article | Press Release

IL-9-Producing Invariant NKT Cells Protect against DSS-Induced Colitis in an IL-4-Dependent Manner
Researchers found that interleukin (IL)-9-producing invariant natural killer T (iNKT) cells protect against dextran sulfate sodium-induced colitis through interferon-γ and IL-17A suppression, but IL-10 and tumor growth factor-β enhancement, depending on the IL-4 production by iNKT cells. [Mucosal Immunol] Abstract

Th17 Responses in Chronic Allergic Airway Inflammation Abrogate Regulatory T-Cell-Mediated Tolerance and Contribute to Airway Remodeling
Scientists demonstrated that both parenteral and mucosal allergen sensitization, followed by allergen inhalation, leads to T-helper type 17 (Th17)-biased lung immune responses. Unlike Th17 cells generated in vitro, lung Th17 cells did not produce tumor necrosis factor-α or interleukin interleukin-22. [Mucosal Immunol] Abstract

Phase I Trial of a Multi-Epitope-Pulsed Dendritic Cell Vaccine for Patients with Newly Diagnosed Glioblastoma
Researchers evaluated the safety and immune responses to an autologous dendritic cell vaccine pulsed with class I peptides from tumor-associated antigens expressed on gliomas and overexpressed in their cancer stem cell population. [Cancer Immunol Immunother] Abstract | Full Article | Press Release 

Whitepaper: Automated Cell Isolation Enables More Relevant HIV Models

INDUSTRY NEWS

Cancer Research Institute Awards $10 Million in Grants to Advance Immune-Based Treatments for Cancer
Cancer Research Institute, Inc. announced that it has committed more than $10 million in new funds to accelerate cancer immunology research and cancer immunotherapy clinical development at research centers worldwide. [Cancer Resarch Institute] Press Release

New Pancreatic Cancer Clinical Trial Applies Revolutionary Immunotherapy Approach That Genetically Modifies T Cells
The Lustgarten Foundation and the Cancer Research Institute are co-sponsoring a new approach to the treatment of pancreatic cancer. A new clinical trial led by Dr. Carl June and Dr. Gregory Beatty at the Perelman School of Medicine at the University of Pennsylvania will focus on altering and training a patient’s immune system to target and eliminate cancer cells. [Cancer Research Institute] Press Release

Atreca, Inc. Licenses Transformational Immune Repertoire CaptureTM Technology from Stanford University
Atreca, Inc. announced that Stanford University has granted the company an exclusive license to transformational technology for harnessing the power of the immune response to generate a wide range of medical products. [Atreca, Inc.] Press Release

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW Free CIRM Webinar – Immune Response in Stem Cell-Based Therapy: Presentations by the FDA and Leading Experts
September 27 10:00AM (PT in US)
Webinar


NEW World Immune Regulation Meeting-VII
March 13-16, 2013
Davos, Switzerland


Visit our events page to see a complete list of events in the immune regulation community.

JOB OPPORTUNITIES

Research Technologist – Media Development (STEMCELL Technologies, Inc.)


Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)


Postdoctoral Position – Immunology (San Raffaele Scientific Institute)


Postdoctoral Research Position (University Lille 2 France)


Postdoctoral Position – Immunology (Louisiana State University)

Postdoctoral Position – Immunology (San Raffaele Scientific Institute)

Research Technician I – Immunology (La Jolla Institute for Allergy and Immunology)


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