Volume 4.25 | Jul 6

Immune Regulation News 4.25 July 6, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Follicular Dendritic Cells Emerge from Ubiquitous Perivascular Precursors
The differentiation of follicular dendritic cells (FDC) is essential to the remarkable microanatomic plasticity of lymphoid follicles. Scientists showed that FDC arise from ubiquitous perivascular precursors expressing platelet-derived growth factor receptor β. [Cell] Abstract | Press Release

Whitepaper: Automated Cell Isolation Enables More Relevant HIV Models
PUBLICATIONS (Ranked by impact factor of the journal)

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict
Regulatory T (Treg) cells, whose differentiation and function are controlled by X chromosome-encoded transcription factor Foxp3, are generated in the thymus (tTreg) and extrathymically (peripheral, pTreg), and their deficiency results in fatal autoimmunity. Researchers demonstrated that a Foxp3 enhancer, conserved noncoding sequence 1, essential for pTreg but dispensable for tTreg cell generation, is present only in placental mammals. [Cell] Abstract

Aiolos Promotes TH17 Differentiation by Directly Silencing Il2 Expression
Researchers report that under interleukin 17-producing helper T cell (TH17)-polarizing conditions, the transcription factors STAT3 and AhR upregulated the expression of Aiolos, a member of the Ikaros family of transcription factors. Using Aiolos-deficient mice, they demonstrated that Aiolos silenced the Il2 locus, promoting TH17 differentiation in vitro and in vivo. [Nat Immunol] Abstract

IL-23 Induces Spondyloarthropathy by Acting on ROR-γt+ CD3+CD4CD8 Entheseal Resident T Cells
Researchers showed that interleukin-23 (IL-23) is essential in enthesitis and acts on previously unidentified IL-23 receptor (IL-23R)+, RAR-related orphan receptor γt (ROR-γt)+CD3+CD4CD8, stem cell antigen 1 (Sca1)+ entheseal resident T cells. [Nat Med] Abstract

The Receptor Ly108 Functions as a SAP Adaptor-Dependent On-Off Switch for T Cell Help to B Cells and NKT Cell Development
The authors found that deletion of receptor Ly108 in CD4+ T cells reversed the adaptor protein SAP−/− phenotype, eliminating the SAP requirement for germinal centers. This potent negative signaling by Ly108 required immunotyrosine switch motifs and SHP-1 recruitment, resulting in high amounts of SHP-1 at the T cell:B cell synapse, limiting T cell:B cell adhesion. [Immunity] Abstract

NK Cell-Derived Interferon-γ Orchestrates Cellular Dynamics and the Differentiation of Monocytes into Dendritic Cells at the Site of Infection
Researchers showed that, after intraperitoneal infection with Toxoplasma gondii cysts, resident mononuclear phagocytes are replaced by circulating monocytes that differentiate in situ into inflammatory dendritic cells and F4/80+ macrophages. [Immunity] Abstract

Long-Term Remission of Diabetes in NOD Mice Is Induced by Nondepleting Anti-CD4 and Anti-CD8 Antibodies
Researchers showed that a short course of nondepleting antibodies specific for the CD4 and CD8 coreceptors rapidly reversed clinical disease in recent-onset diabetic NOD mice. Once established, remission was maintained indefinitely and immunity to foreign antigens unimpaired. [Diabetes]
Abstract | Press Release

Systemic Vaccination Induces Clonally Diverse SIV-Specific CD8+ T-Cell Populations in Systemic and Mucosal Compartments
Researchers showed that systemic delivery of prototype vaccine vectors in rhesus monkeys induced SIV (simian immunodeficiency virus)-specific CD8+ T-cell responses in systemic and mucosal compartments with comparable clonal compositions. [Mucosal Immunol] Abstract

Harnessing Oncolytic Virus-Mediated Antitumor Immunity in an Infected Cell Vaccine
Researchers developed a potent oncolytic vaccine platform, consisting of tumor cells infected with VSV-Δ51. They demonstrated that prophylactic immunization with this infected cell vaccine protected mice from subsequent tumor challenge, and expression of granulocyte-monocyte colony stimulating factor by the virus increased efficacy. [Mol Ther] Abstract

Inducible IL10+ Suppressor B Cells Inhibit CNS Inflammation and T Helper 17 Polarization
Researchers demonstrated that a synthetic cytokine linking granulocyte-macrophage colony-stimulating factor to MCP3 has enhanced CC-chemokine receptor-mediated intracellular Ca++ mobilization with selective effects on the CD21hiCD24hi CD1.dhi subset of splenic B cells inducing substantial interleukin 10 (IL10) production. [Mol Ther] Abstract

Term and Preterm Labor: Decreased Suppressive Activity and Changes in Composition of the Regulatory T-Cell Pool
Researchers examined whether there were differences in the percentage of the total CD4+CD127low+/−CD25+FoxP3+-regulatory T (Treg)-cell pool, its suppressive activity and its composition with distinct Treg subsets between preterm and term laboring women. [Immunol Cell Biol] Abstract

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INDUSTRY NEWS

Lorus Therapeutics Announces Issuance of Canadian Patent for Novel Anticancer Therapy IL-17E
The Canadian patent protects the use of IL-17E to treat cancer, including many different solid tumors such as colon, breast, ovarian, pancreatic, and lung cancers as well as melanoma until 2026. [Lorus Therapeutics, Inc.] Press Release

Medistem Receives Notice of Patent Allowance Covering Fat Stem Cell Therapy of Autoimmune Diseases
Medistem Inc. announced notice of allowance from the United States Patent and Trademark Office for a patent covering the use of fat stem cells, and cells associated with fat stem cells for treatment of diseases related to a dysfunctional immune system. [MarketWatch] Press Release


Argos Therapeutics Receives FDA Approval of Special Protocol Assessment for AGS-003 Phase III Trial
Argos Therapeutics Inc. announced that the U.S. Food & Drug Administration (FDA) has approved the Company´s revised Special Protocol Assessment for its Phase III clinical study of AGS-003 for the treatment of metastatic renal cell carcinoma. [Argos Therapeutics Inc.] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Antigen Processing and Presentation in Health and Disease
November 15-16, 2012
Luxembourg, Luxembourg


NEW Emerging Topics in Immune System Plasticity: Cellular Networks, Metabolic Control and Regeneration
January 15-20, 2013
Santa Fe, United States


Visit our events page to see a complete list of events in the immune regulation community.

JOB OPPORTUNITIES

Research Associate – Chemistry (STEMCELL Technologies, Inc.)


Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)


Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)


Research Technologist – Media Development (STEMCELL Technologies, Inc.)


Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)


Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)


Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)


Postdoctoral Position – Protein Chemistry/Immuno-Receptor Biology (Genentech)


Postdoctoral Position – Immunology (San Raffaele Scientific Institute)


Postdoctoral Research Position (University Lille 2 France)


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