Volume 4.16 | May 4

Immune Regulation News 4.16, May 4, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
NLRP10 Is a NOD-Like Receptor Essential To Initiate Adaptive Immunity by Dendritic Cells
Researchers found that the loss of antigen transport to the draining lymph nodes by a subset of migratory dendritic cells (DCs) resulted in an almost absolute loss in naive CD4+ T-cell priming, highlighting the critical link between diverse innate immune stimulation, NOD-like receptor P10 (NLRP10) activity and the immune function of mature DCs. [Nature] Abstract


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PUBLICATIONS (Ranked by Impact Factor of the Journal)

AID-Driven Deletion Causes Immunoglobulin Heavy Chain “Locus Suicide Recombination” in B Cells
Remodeling of immunoglobulin genes by activation-induced deaminase (AID) is required for affinity maturation and class switch recombination in mature B lymphocytes. In the immunoglobulin heavy chain locus, these processes are predominantly controlled by the 3′ cis-regulatory region. This study revealed that this region is transcribed and undergoes AID-mediated mutation and recombination around phylogenetically conserved switch-like DNA repeats. [Science] Abstract

TRIM28 Prevents Autoinflammatory T Cell Development In Vivo
By studying mice with conditional T cell-specific deletion of TRIM28, researchers found that TRIM28 was phosphorylated after stimulation via the T cell antigen receptor and was involved in the global regulation of CD4+ T cells. [Nat Immunol] Abstract

TGF-β and Retinoic Acid Induce the MicroRNA miR-10a, which Targets Bcl-6 and Constrains the Plasticity of Helper T Cells
Researchers report that naturally occurring regulatory T cells (Treg cells) had high expression of the microRNA miR-10a and that miR-10a was induced by retinoic acid and transforming growth factor-β (TGF-β) in inducible Treg cells. [Nat Immunol] Abstract

Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells
Using only autologous human tissues, researchers report that both in vitro and in vivo, resting epidermal Langerhan cells selectively and specifically induced the activation and proliferation of skin resident regulatory T cells, a minor subset of skin resident memory T cells. [Immunity] Abstract | Press Release

Adaptor Protein-3 in Dendritic Cells Facilitates Phagosomal Toll-Like Receptor Signaling and Antigen Presentation to CD4+ T Cells
The authors showed that dendritic cells from adaptor protein-3-deficient pearl mice elicited impaired CD4+ T cell activation and Th1 effector cell function to particulate antigen in vitro and to recombinant Listeria monocytogenes infection in vivo. [Immunity] Abstract

Resident CD141 (BDCA3)+ Dendritic Cells in Human Skin Produce IL-10 and Induce Regulatory T Cells that Suppress Skin Inflammation
Researchers identified an immunoregulatory tissue-resident dendritic cell in the dermis of human skin that is characterized by surface expression of CD141, CD14, and constitutive IL-10 secretion. [J Exp Med] Abstract

Cytotoxic Immunological Synapses Do Not Restrict the Action of Interferon-γ to Antigenic Target Cells
Researchers developed a live-cell imaging system to compare the responses of target cells and nonantigenic bystanders to IFN-γ secreted by CD8+, antigen-specific, cytotoxic T cells. [Proc Natl Acad Sci USA]
Abstract | Press Release

Altered Regulation of Toll-Like Receptor Responses Impairs Antibacterial Immunity in the Allergic Lung
Using the intranasal house-dust mite-sensitized mouse model of allergic airway disease, researchers showed an imbalance in novel antibacterial pathways that culminates in a reduction in neutrophil recruitment to the airspaces and leads to bacterial invasion and dissemination. [Mucosal Immunol]
Abstract

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells
Researchers report long-term results from three clinical trials to evaluate gammaretroviral vector-engineered T cells for HIV. [Sci Transl Med] Abstract | Press Release


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INDUSTRY NEWS

Argos Therapeutics Secures $25 million Series D Financing to Commence Phase III ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
Argos Therapeutics Inc. announced that it has secured a $25 million Series D financing to support the commencement of its Phase III ADAPT study in patients with newly diagnosed mRCC in mid-2012. [MarketWatch] Press Release


Bioo Scientific Launches Transduction Reagents for Targeted Delivery into Neuronal and Myeloid Cells
Bioo Scientific announced that it has launched the proprietary MyeloAim™ and NeuroAim™ Transduction Reagents, which offer directed delivery of RNAi agents into myeloid cells (both in primary cells and in cell lines) or into neuronal cells (both in primary cells and in cell lines), respectfully. [Bioo Scientific Corp.]
Press Release

POLICY NEWS

Chinese Publishers Vow to Cleanse Journals
The China Association for Science and Technology in Beijing has taken the lead among the country’s publishers in trying to clamp down on academic misconduct. [The China Association for Science and Technology, China] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 5th International Singapore Symposium of Immunology
June 7-8, 2012
Singapore, Singapore


Visit our events page to see a complete list of events in the immune regulation community.
JOB OPPORTUNITIES

Research Associate – Chemistry (STEMCELL Technologies, Inc.)


Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)


Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)


Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)  


Cell Biologist – Innate Immune Response (University Medical Center, Utrecht)

Postdoctoral Position – Protein Chemistry/Immuno-Receptor Biology (Genentech)


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