Volume 4.10 | Mar 16

Immune Regulation News 4.10, March 16, 2012
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Goblet Cells Deliver Luminal Antigen to CD103+ Dendritic Cells in the Small Intestine
Using a minimally disruptive in vivo imaging approach researchers show that in the steady state, small intestine goblet cells function as passages delivering low molecular weight soluble antigens from the intestinal lumen to underlying CD103+ lamina propria-dendritic cells. [Nature] Abstract | Press Release

View Lectures, Tools, Protocols and Other Resources on the Human Immunology Portal (www.humanimmunologyportal.com)
PUBLICATIONS (Ranked by Impact Factor of the Journal)

Molecular Mechanisms that Control the Expression and Activity of Bcl-6 in TH1 Cells to Regulate Flexibility with a Follicular Helper T Cell-Like Gene Profile
Here researchers found that high concentrations of interleukin 2 inhibited Bcl-6 expression in polarized T helper type 1 cells (TH1 cells). [Nat Immunol] Abstract

Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium
Researchers’ data attributed a functional importance to the temporal development of Vγ5+ γδ T cells during thymus medulla formation for αβ T cell tolerance induction and demonstrated a Rank-mediated reciprocal link between dendritic epidermal T cells and autoimmune regulator positive (Aire+) medullary thymic epithelial cell maturation. [Immunity] Abstract

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation
Here investigators report that innate lymphocytes termed lung natural helper cells are a T cell-independent source of T helper 2 (Th2) cell-type cytokines in protease allergen-treated lungs. [Immunity] Abstract

E Protein Transcription Factors Are Required for the Development of CD4+ Lineage T Cells
Here, researchers have demonstrated that in addition to regulating the onset of the double-positive to single-positive transition during T cell development, HEB and E2A also play a separate role in CD4+ lineage choice. [Immunity] Abstract

Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation
Herein, scientists demonstrate that inactivation of Foxo1 was essential for instructing T-bet transcription factor-mediated effector differentiation of CD8+ T cells. [Immunity] Abstract

Immune Insufficiency during GvHD Is Due to Defective Antigen Presentation within Dendritic Cell Subsets
Immune suppression due to alloreactivity after transplantation is most profound during graft-versus-host disease (GvHD) after bone marrow transplantation where an inflammatory cytokine storm dominates. Contrary to current dogma, which avers that this is a T-cell defect, researchers demonstrate that the impairment lies within conventional dendritic cells. [Blood] Abstract

Cancer-Associated Epithelial Cell Adhesion Molecule (EpCAM; CD326) Enables Epidermal Langerhans Cell Motility and Migration In Vivo
To gain insight into EpCAM function in a physiologic context in vivo, researchers generated conditional knockout mice with EpCAM-deficient Langerhans cells and characterized them. [Proc Natl Acad Sci USA] Abstract

Signal Transducer and Activator of Transcription-3/Suppressor of Cytokine Signaling-3 (STAT3/SOCS3) Axis in Myeloid Cells Regulates Neuroinflammation
To determine the role of SOCS3 in myeloid cells in neuroinflammation, mice with conditional SOCS3 deletion in myeloid cells were tested for experimental autoimmune encephalomyelitis. [Proc Natl Acad Sci USA] Abstract

Adoptive Transfer with In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice
This study aimed to determine the ability of human regulatory T cells to prevent islet xenograft rejection and the mechanism(s) involved. [Diabetes] Abstract

A Model for Personalized In Vivo Analysis of Human Immune Responsiveness
Here, researchers demonstrated robust immune reconstitution in mice with hematopoietic stem cells aspirated from bone marrow of adults with type 1 diabetes and healthy control volunteers. [Sci Transl Med]
Abstract | Press Release

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SCIENCE NEWS
Inovio Pharmaceuticals’ PENNVAX®-B HIV Vaccine Demonstrates Strong T-Cell Immune Responses in Therapeutic Vaccine Trial
Inovio Pharmaceuticals, Inc. announced that it has achieved strong T cell immune responses in a Phase I clinical study of PENNVAX®-B, its product for the treatment of the HIV subtype prevalent in North America and Europe, in HIV-positive subjects. [Press release from Inovio Pharmaceuticals, Inc. discussing research presented at the Vaccine World Summit 2012, Hyderabad] Press Release
INDUSTRY NEWS

DSM and Agennix Sign New Contract for Commercial Manufacture of Talactoferrin
DSM Pharmaceutical Products (DSM) and Agennix AG have signed a new contract under which DSM will continue to manufacture talactoferrin for Agennix at commercial levels. [DSM Pharmaceutical Products] Press Release

Prima Receives TGA Manufacturing License for CVac™ in Australia
Prima BioMed Ltd announced that it has received a manufacturing license from the Therapeutic Goods Administration (TGA) to produce the CVac™ immunotherapy ovarian cancer vaccine in Australia. [Prima BioMed Ltd] Press Release

Alliance for Advanced Therapies to Officially Launch at BIO-Europe Spring® 2012
EBD Group announced that the Alliance for Advanced Therapies (AAT) will launch at the BIO-Europe Spring® 2012 partnering event. The ATT is a new organization devoted to supporting cell therapy, regenerative medicine and other potentially life-saving advanced therapeutics in Europe. [EBD Group AG] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 8th International Congress on Autoimmunity
May 9-13, 2012
Granada, Spain

NEW European Congress of Immunology (ECI) 2012
September 5-8, 2012
Glasgow, United Kingdom

Visit our events page to see a complete list of events in the immune regulation community.

JOB OPPORTUNITIES

Scientist – Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)  

Postdoctoral Fellow (Medical Research Council)

Postdoctoral Fellow – Transplant Immunology (Regensburg Center of Interventional Immunology)

Postdoctoral Position in Molecular Immunology (Karmanos Cancer Institute)


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