Volume 4.06 | Feb 17

Immune Regulation News 4.06, February 17, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model
Researchers have generated mice expressing the transforming Epstein-Barr virus latent membrane protein 1 (LMP1), mimicking a constitutively active CD40 coreceptor, specifically in B cells. [Cell] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

The Circadian Clock Controls Toll-Like Receptor 9-Mediated Innate and Adaptive Immunity
Researchers demonstrate the circadian molecular clock controls the expression and function of Toll-like receptor 9. [Immunity] Abstract | Press Release

Cxcr2 and Cxcl5 Regulate the IL-17/G-CSF Axis and Neutrophil Homeostasis in Mice
Scientists report here that Cxcr2 on murine neutrophils inhibits the IL-17A/G-CSF axis that regulates neutrophil homeostasis. [J Clin Invest] Abstract

Regulatory T Cells Control the CD8 Adaptive Immune Response at the Time of Ductal Obstruction in Experimental Biliary Atresia
Here, researchers hypothesize that neonatal deficiency in CD25+CD4+ regulatory T cells leads to aberrant activation of hepatic T-lymphocytes in biliary atresia. [Hepatology] Abstract

Severe Necroinflammatory Reaction Caused by Natural Killer by Fas/FasL Interaction and Dendritic Cells in Human Hepatocyte Chimeric Mouse
Here scientists demonstrate elimination of hepatitis B virus-infected hepatocytes by natural killer cells and dendritic cells using urokinase-type plasminogen activator-severe combined immunodeficiency mice in which the livers were highly repopulated with human hepatocytes. [Hepatology] Abstract

Nuclear Receptor Nr4a1 Modulates Both Regulatory T-Cell (Treg) Differentiation and Clonal Deletion
Researchers show that Nr4a1 appears to act as a balancing molecule in fate determination at a critical juncture of T-cell differentiation. [Proc Natl Acad Sci USA] Abstract

Mutual Antagonism of TGF-Beta and Interleukin-2 in Cell Survival and Lineage Commitment of Induced Regulatory T Cells
Here, researchers investigated the behavior of induced regulatory T cells, derived from apoptosis-defective mouse mutants, during activated cell autonomous cell death, triggered by cytokine-deprivation, or activation-induced cell death after restimulation of the T-cell receptor, and compared these responses with those of effector T cells. [Cell Death Differ] Abstract

Plasmacytoid Dendritic Cells and Th17 Immune Response Contribution in Gastro-Intestinal Acute Graft-versus-Host-Disease
In this study, scientists have shown that the absolute number of Th17 cells using the CCR6 and CD161 markers were significantly higher in the intestinal mucosa of patients with acute graft-versus-host-disease (aGvHD) compared with intestinal mucosa of patients without aGvHD. [Leukemia] Abstract

Cutting Edge: The Role of IFN-α Receptor and MyD88 Signaling in Induction of IL-15 Expression In Vivo
To visualize IL-15 expression, researchers created a transgenic mouse expressing emerald-GFP under IL-15 promoter control. [J Immunol] Abstract

Inducible Hsp70 Reduces T Cell Responses and Stimulatory Capacity of Monocyte-Derived Dendritic Cells
In this study investigators used low endotoxin inducible heat shock protein 70 (Hsp70), and observed that after 24-hour incubation of monocyte-derived immature dendritic cells with 20 μg/ml of low endotoxin Hsp70 their ability to stimulate allogenic T cells was reduced. [J Biol Chem] Abstract

Interferon-γ-Producing Immature Myeloid Cells Confer Protection against Severe Invasive Group A Streptococcus Infections
Here investigators show that mice infected with severe invasive group A Streptococcus isolates, but not with non-invasive group A Streptococcus isolates, exhibit high concentrations of plasma interferon-γ during the early stage of infection. [Nat Commun] Abstract

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INDUSTRY NEWS

Lupus Research Institute Awards $3.6 Million for Novel Studies Driving Wide-Ranging New Science in Lupus
The Lupus Research Institute awarded 12 “Novel Research Grants” to jumpstart discovery in lupus by supporting original, highly promising ideas from some of the country’s most creative scientists. Studies will look at why lupus turns the body’s immune system against itself and pioneer strategies for new treatment development. [Lupus Research Institute] Press Release

Did an Evolutionary Arms Race Cause Lupus? Biologist Harmit Malik Receives Grant From Lupus Research Institute to Find Out
Evolutionary biologist Harmit Singh Malik, Ph.D., of Fred Hutchinson Cancer Research Center, has received a $300,000 grant from the Lupus Research Institute to study the potential role of “genetic conflicts” in the development of lupus, an autoimmune disease. [Fred Hutchinson Cancer Research Center] Press Release

InnaVirVax Lands $4.9 Million in Series B Funding Round
InnaVirVax, a biopharmaceutical company dedicated to the development of therapeutic and diagnostic solutions in pathologies associated with immune dysregulation, announced the closing of a $4.9 million Series B round of funding. [InnaVirVax] Press Release

POLICY NEWS

Prospective Grant of Exclusive License: The Development of Human Anti-CD22 Monoclonal Antibodies for the Treatment of Human Cancers and Autoimmune Disease (FR Doc No: 2012-3829) [National Institutes of Health, United States]

Prospective Grant of Exclusive License: Photosensitizing Antibody-Fluorophore Conjugates for Photo-Immunotherapy (FR Doc No: 2012-3828) [National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Experimental Biology (EB) 2012
April 21-25, 2012
San Diego, United States

NEW Immunology 2012 – 99th American Association of Immunologists (AAI) Annual Meeting
May 4-8, 2012
Boston, United States

Visit our events page to see a complete list of events in the immune regulation community.

JOB OPPORTUNITIES

Scientist – Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Research Technologist (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)  

Immunology Investigator (BloodCenter of Wisconsin)

Postdoctoral Fellow – Program in Children’s Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Positions in Allergy and Immunology (University of Southern California)

Postdoctoral Position in Molecular Immunology (Karolinska Institutet)


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