Volume 4.00 | Jan 6

Immune Regulation News 4.00 January 6, 2012
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Activation-Induced B Cell Fates Are Selected by Intracellular Stochastic Competition
Stochastic competition can explain how the allocation of a proportion of B cells to each cell fate is achieved. [Science] Abstract

Free Demo: Isolate Cells in the New 96-Well EasySep™ EasyPlate Magnet
PUBLICATIONS (Ranked by Impact Factor of the Journal)
Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
Scientists have shown here that CD8+ memory T cells, but not CD8+ T effector cells, possessed substantial mitochondrial spare respiratory capacity. [Immunity] Abstract

TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils
Findings identify a previously unrecognized role of TGF-β activated kinase-1 (TAK1) as a negative regulator of p38 and IKK activation in a cell type-specific manner. [Immunity] Abstract

Lymph Node T Cell Homeostasis Relies on Steady State Homing of Dendritic Cells
Applying different mouse models, including conditionally proficient Ccr7 gene-targeted mice, researchers now show that semi-mature steady state dendritic cells constitutively trafficking into lymph nodes were essential contributors to T cell homeostasis in these organs. [Immunity] Abstract

The Transcription Factor Myc Controls Metabolic Reprogramming Upon T Lymphocyte Activation
Two of the top-ranked candidate transcription factors potentially responsible for the activation-induced T cell metabolic transcriptome, HIF1α and Myc, were induced upon T cell activation, but only the acute deletion of Myc markedly inhibited activation-induced glycolysis and glutaminolysis in T cells. [Immunity] Abstract

Requirements of Transcription Factor Smad-Dependent and -Independent TGF-β Signaling to Control Discrete T-Cell Functions
In this study, scientists investigated the requirements of Smad-dependent and -independent TGF-β signaling for T-cell function. [Proc Natl Acad Sci USA] Abstract
 
A Tolerogenic Role for Toll-Like Receptor 9 Is Revealed by B-Cell Interaction with DNA Complexes Expressed on Apoptotic Cells
Here researchers report that IL-10 production by B cells, stimulated by contact with apoptotic cells (ACs), results from the engagement of Toll-like receptor 9 within the B cell after recognition of DNA-containing complexes on the surface of ACs. [Proc Natl Acad Sci USA] Abstract

Combined Tbet and IL12 Gene Therapy Elicits and Recruits Superior Antitumor Immunity In Vivo
Since IL-12 is a classical promoter of type-1 immunity, the current study was undertaken to determine whether gene therapy using combined Tbet and IL-12 complementary DNA would yield improved antitumor efficacy based on the complementary/synergistic action of these biologic modifiers. [Mol Ther] Abstract

Human Regulatory T Cells Rapidly Suppress T Cell Receptor–Induced Ca2+, Nuclear Factor-κB, and Nuclear Factor of Activated T Cell Signaling in Conventional T Cells
Here, scientists showed that human regulatory T cells rapidly suppressed the release of calcium ions (Ca2+) from intracellular stores in response to T cell receptor activation in conventional T cells. [Sci Signal]
Abstract | Press Release

Cells Exposed to Sublethal Oxidative Stress Selectively Attract Monocytes/Macrophages via Scavenger Receptors and MyD88-Mediated Signaling
In this study, researchers looked for early signals that direct immune cells to cells undergoing stress before irreversible damage takes place. [J Immunol] Abstract

Surfactant Protein A Integrates Activation Signal Strength to Differentially Modulate T Cell Proliferation
Investigators hypothesized that surfactant protein A-mediated modulation of T cell activation depends upon the strength, duration, and type of lymphocyte activating signals. [J Immunol] Abstract

Dominant Th2 Differentiation of Human Regulatory T Cells Upon Loss of FOXP3 Expression
Researchers compared the transcriptomes of stable FOXP3+ regulatory T cells (Treg) and converted FOXP3 ex-Treg by applying a newly developed intranuclear staining protocol that permits the isolation of intact mRNA from fixed, permeabilized, and FACS-purified cell populations. [J Immunol] Abstract

Population Dynamics of Naive and Memory CD8 T Cell Responses After Antigen Stimulations In Vivo
To explore cell-autonomous functional differences between naive and memory CD8 T cells that are not influenced by differences in the priming environment, an experimental model has been developed in which physiological numbers of both populations of cells were co-transferred into naive hosts before Ag stimulation. [J Immunol] Abstract

Influenza A Virus Infection Results in a Robust, Antigen-Responsive and Widely Disseminated Foxp3 Regulatory T Cell Response
The present study sought to examine the induction of Foxp3+CD4+ regulatory T cells in a non-lethal murine model of pulmonary viral infection using the prototypical respiratory virus influenza A. [J Virol] Abstract

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SCIENCE NEWS
Celldex Initiates a Phase II Study of Rindopepimut in Patients with Recurrent Glioblastoma Including Avastin® Naive and Refractory Populations
Celldex Therapeutics, Inc. announced that patient screening was initiated in a Phase II trial of rindopepimut in combination with Avastin® in patients with recurrent epidermal growth factor variant III-positive glioblastoma, called the “ReACT Study.” [Celldex Therapeutics, Inc.] Press Release

Major Milestone Achieved: The Phase IIa Clinical Trial in Rheumatoid Arthritis Meets Its Endpoint
Neovacs announced the full results for its TNF-K-003 clinical trial with TNF-Kinoid in rheumatoid arthritis. [Neovacs] Press Release
INDUSTRY NEWS
Rigel Announces Initiation of Clinical Trials in Two Immunology Programs
Rigel Pharmaceuticals, Inc. announced that two of its lead product candidates entered clinical trials during the fourth quarter of 2011. [Rigel Pharmaceuticals, Inc.] Press Release

Michael A. Marletta Takes Office as New President of Scripps Research Institute
Renowned biochemist Michael A. Marletta, PhD, assumed the post of president and CEO of The Scripps Research Institute January 1, succeeding Richard A. Lerner, MD, who led the institution for more than two decades. [The Scripps Research Institute] Press Release

Immunomedics and UCB Announce Restructuring of Epratuzumab License Agreement
Immunomedics, Inc. and UCB S.A. announced that they have amended their Development, Collaboration and License Agreement for the exclusive worldwide rights to develop, market and sell epratuzumab for all autoimmune disease indications. [UCB S.A.] Press Release
POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW The 51st Midwinter Conference of Immunologists
January 28-31, 2012
Pacific Grove, United States

NEW Keystone Symposia on Molecular and Cellular Biology: Th17 Cells in Health and Disease
February 5-10, 2012
Keystone, United States

NEW Keystone Symposia on Molecular and Cellular Biology: The Biology of Cytokines
February 5-10, 2012
Keystone, United States

Visit
our events page to see a complete list of events in the immune regulation community.
JOB OPPORTUNITIES
Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)  

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Postdoctoral Research Scientist (University of Oxford)

Immunology Investigator (BloodCenter of Wisconsin)

Postdoctoral Fellow in Immunology: T Cell Development and Migration (University of Chicago)

Postdoctoral Fellow (University of Cincinnati)


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