Volume 3.43 | Nov 25

Immune Regulation News 3.43, November 25, 2011
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs
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Recipient’s Immune System Governs Stem Cell Regeneration
A new study describes how different types of immune system T-cells alternately discourage and encourage stem cells to regrow bone and tissue, bringing into sharp focus the importance of the transplant recipient’s immune system in stem cell-based regeneration. [Press release from the University of Southern California discussing online prepublication in Nature Medicine] Press Release | Abstract

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Natural Killer Cells Act as Rheostats Modulating Antiviral T Cells
Here researchers examine the roles of natural killer cells in regulating T-cell-dependent viral persistence and immunopathology in mice infected with lymphocytic choriomeningitis virus, an established model for human immunodeficiency virus and hepatitis C virus infections in humans. [Nature] Abstract

Lyn Is a Redox Sensor that Mediates Leukocyte Wound Attraction In Vivo
Here investigators identify the Src family kinase Lyn as a redox sensor that mediates initial neutrophil recruitment to wounds in zebrafish larvae. [Nature] Abstract | Press Release

Aryl Hydrocarbon Receptor (AHR) Drives the Development of Gut ILC22 Cells and Postnatal Lymphoid Tissues via Pathways Dependent on and Independent of Notch
Here researchers found that Ahr−/− mice had a considerable deficit in innate lymphoid cell 22 (ILC22) cells that resulted in less secretion of interleukin 22 and inadequate protection against intestinal bacterial infection. [Nat Immunol] Abstract

The Redox-Sensitive Cation Channel TRPM2 Modulates Phagocyte ROS Production and Inflammation
Here scientists report that TRPM2, a nonselective and redox-sensitive cation channel, inhibited reactive oxygen species (ROS) production in phagocytic cells and prevented endotoxin-induced lung inflammation in mice. [Nat Immunol] Abstract

Enforced Viral Replication Activates Adaptive Immunity and Is Essential for the Control of a Cytopathic Virus
Researchers found that enforced viral replication in marginal zone macrophages was an immunological mechanism that ensured the production of sufficient antigen for effective activation of the adaptive immune response. [Nat Immunol] Abstract

Crosstalk between B Lymphocytes, Microbiota and the Intestinal Epithelium Governs Immunity versus Metabolism in the Gut
Researchers found that, in the absence of B cells, or of IgA, and in the presence of the microbiota, the intestinal epithelium launches its own protective mechanisms, upregulating interferon-inducible immune response pathways and simultaneously repressing Gata4-related metabolic functions. [Nat Med] Abstract

A Mechanism for Glycoconjugate Vaccine Activation of the Adaptive Immune System and Its Implications for Vaccine Design
In this study, the researchers’ discovery of how glycoconjugates are processed resulting in presentation of carbohydrate epitopes that stimulate CD4+ T cells has key implications for glycoconjugate vaccine design that could result in greatly enhanced vaccine efficacy. [Nat Med] Abstract

An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells
This study shows that the interleukin-10 (IL-10)-IL-21-STAT3 pathway is critical for memory CD8+ T cell development after acute LCMV infection. [Immunity] Abstract

Eomesodermin Controls Interleukin-5 Production in Memory T Helper 2 Cells through Inhibition of Activity of the Transcription Factor GATA3
Here investigators show that memory T helper 2 cells are divided into four subpopulations by CD62L and CXCR3 expression. All four subpopulations produced interleukin-4 (IL-4) and IL-13, whereas only the CD62LloCXCR3lo population produced IL-5 accompanied by increased H3-K4 methylation at the Il5 gene locus. [Immunity] Abstract

Glucocorticoid Therapy of Antigen-Induced Arthritis Depends on the Dimerized Glucocorticoid Receptor in T Cells
Using cell type-specific glucocorticoid receptor-deficient mice subjected to antigen-induced arthritis (AIA) as a model of human rheumatoid arthritis, researchers show that glucocorticoid action on T cells but not myeloid cells is critical for therapeutic intervention in AIA. [Proc Natl Acad Sci USA] Abstract

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Galapagos’ GLPG0634 Shows Excellent Efficacy and Safety in Rheumatoid Arthritis Phase II Study
Galapagos NV announced that its JAK1 inhibitor, GLPG0634, achieved the primary endpoint of significant improvement in the signs and symptoms of rheumatoid arthritis. [Galapagos NV] Press Release

Pfizer Announces European Medicines Agency Acceptance of Regulatory Submission for Tofacitinib for the Treatment of Rheumatoid Arthritis
Pfizer Inc. announced that its Market Authorization Application for tofacitinib (development code CP-690,550), a novel, oral JAK inhibitor being studied for the treatment of moderate-to-severe active rheumatoid arthritis, has been validated by the European Medicines Agency. [Pfizer Inc.] Press Release

MSRCNY Receives Approval for Groundbreaking Stem Cell Trial in Multiple Sclerosis
The Multiple Sclerosis Research Center of New York (MSRCNY) and the International Cellular Medicine Society (ICMS) jointly announced the ICMS Institutional Review Board’s approval of the first study to use autologous brain-like or neural stem cells for multiple sclerosis. [International Multiple Sclerosis Management Practice] Press Release

U-M Medical School and MedImmune Join Forces to Accelerate Search for New Therapies
Leaders from the University of Michigan (U-M) Medical School and MedImmune, the global biologics arm of AstraZeneca, have signed a new agreement to work together on a broad range of projects. [University of Michigan Health System] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Dutch Society for Immunology Annual Meeting 2011
December 14-15, 2011
Noordwijkerhout, Netherlands

our events page to see a complete list of events in the immune regulation community.

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)  

Postdoctoral Fellow – Immunology & Inflammation (SRI International)

Postdoctoral Fellow (University of Cincinnati)

Assistant Professor – Immunology (University of Saskatchewan)

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