Volume 3.38 | Oct 14

Immune Regulation News 3.38, October 14, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation
Researchers show here that the aryl hydrocarbon receptor is a crucial regulator in maintaining intraepithelial lymphocyte numbers in both the skin and the intestine. [Cell] Abstract | Press Release

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Therapeutic siRNA Silencing in Inflammatory Monocytes in Mice
Here researchers present an optimized lipid nanoparticle and a CCR2-silencing short interfering RNA that, when administered systemically in mice, show rapid blood clearance, accumulate in spleen and bone marrow, and localize to monocytes. [Nat Biotechnol] Abstract | Press Release

The Kinase GLK Controls Autoimmunity and NF-κB Signaling by Activating the Kinase PKC-θ in T Cells
Investigators report that the kinase GLK (MAP4K3) directly activated protein kinase C-θ (PKC-θ) during T cell antigen receptor signaling. [Nat Immunol] Abstract

IL-17RE Is the Functional Receptor for IL-17C and Mediates Mucosal Immunity to Infection with Intestinal Pathogens
Here researchers show that interleukin 17 receptor E (IL-17RE) is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection. [Nat Immunol] Abstract

An IL-9 Fate Reporter Demonstrates the Induction of an Innate IL-9 Response in Lung Inflammation
Here scientists describe a reporter mouse strain designed to map the fate of cells that have activated interleukin 9 (IL-9). [Nat Immunol] Abstract

IL-17C Regulates the Innate Immune Function of Epithelial Cells in an Autocrine Manner
Here researchers show that interleukin 17C (IL-17C) functioned in a unique autocrine manner, binding to a receptor complex consisting of the receptors IL-17RA and IL-17RE, which was preferentially expressed on tissue epithelial cells. [Nat Immunol] Abstract

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation
Here, researchers show that epidermal keratinocyte-restricted deficiency of the adaptor protein FADD induced severe inflammatory skin lesions in mice. [Immunity] Abstract | Press Release

Antigen-Fixed Leukocytes Tolerize Th2 Responses in Mouse Models of Allergy
Scientists hypothesized that antigen (Ag)-specific tolerance induced by the i.v. injection of Ags attached to the surface of syngeneic splenic leukocytes (Ag-coupled splenocytes) with the chemical cross-linking agent ethylene-carbodiimide, which effectively modulate Th1/Th17 diseases, may also safely and efficiently induce tolerance in Th2-mediated mouse models of allergic asthma and food allergy. [J Immunol] Abstract | Press Release

Enhanced Th17-Cell Responses Render CCR2-Deficient Mice More Susceptible for Autoimmune Arthritis
Researchers investigated whether autoimmune-associated Th17 cells were involved in the pathogenesis of the severe phenotype of autoimmune arthritis. [PLoS One] Abstract | Press Release

Vitamin D Is Required for IFN-γ–Mediated Antimicrobial Activity of Human Macrophages
Researchers report that T cells, by the release of interferon-γ (IFN-γ), induce autophagy, phagosomal maturation, the production of antimicrobial peptides such as cathelicidin, and antimicrobial activity against Mycobacterium tuberculosis in human macrophages via a vitamin D–dependent pathway. [Sci Transl Med] Abstract | Press Release

Human TH17 Cells Are Long-Lived Effector Memory Cells
Here, investigators studied human TH17 cells in the pathological microenvironments of graft-versus-host disease, ulcerative colitis, and cancer; TH17 cell numbers were increased in the chronic phase of these diseases. [Sci Transl Med] Abstract

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INDUSTRY NEWS

Oncobiologics, Inc. Announces Two New Agreements Worth Close to $80 Million
Oncobiologics announced that it has signed two major agreements. The first is with Parilis Biopharmaceuticals and involves worldwide licensing for an undisclosed biotherapeutic product. The second is with a US based large pharmaceutical company to conduct research focused on solving issues related to downstream processing of monoclonal antibodies. [Oncobiologics, Inc.] Press Release

International Cytokine Society Honors Dr. Laurie Glimcher
Dr. Laurie Glimcher has received the 2011 International Cytokine Society Honorary Lifetime Membership, the Society’s highest honor, for her pivotal contributions to cytokine research, particularly as it relates to immune response. [Weill Cornell Medical College] Press Release

Center for Modeling Immunity to Enteric Pathogens Releases Revolutionary Software
Researchers have released an upgrade to the revolutionary ENteric Immunity SImulator (ENISI) software. ENISI models immune responses to beneficial and harmful bacteria that enter the gastrointestinal tract of mice, pigs and humans. [Virginia Bioinformatics Institute] Press Release

Nationwide Children’s Hospital Clinical Trial to Use Drug to Boost Immune System Function in Critically Injured Children, May Prevent Infection
Thanks to funding from the National Institutes of Health, Nationwide Children’s Hospital will test the ability of a drug commonly used to improve immune function in pediatric cancer patients to help prevent hospital-acquired infection after severe trauma. [Nationwide Children’s Hospital] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Association for Molecular Pathology 2011 Annual Meeting
November 17-19, 2011
Grapevine, United States

Visit
our events page to see a complete list of events in the immune regulation community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 


Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 


Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Principal Scientist, Immune Disease (Takeda Pharmaceutical Company Limited)

Postdoctoral Position in Immunology (Singapore Immunology Network)

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