Volume 3.37 | Oct 7

Immune Regulation News 3.37, October 7, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Induced Immune Tolerance for Kidney Transplantation
In the current proof-of-concept study, 12 patients who received HLA-matched kidney transplants received a donor-cell infusion of highly enriched CD34+ hematopoietic progenitor cells mixed with CD3+ T cells, and a conditioning regimen of total lymphoid irradiation and anti–T-cell antibodies according to a protocol described in detail in a previous case report of the successful
induction of tolerance. [N Engl J Med] Abstract | Press Release

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Complement Factor H Binds Malondialdehyde Epitopes and Protects from Oxidative Stress
Here researchers identify complement factor H as a major malondialdehyde (MDA)-binding protein that can block both the uptake of MDA-modified proteins by macrophages and MDA-induced proinflammatory effects in vivo in mice. [Nature] Abstract | Press Release

A Motif in the V3 Domain of the Kinase PKC-θ Determines its Localization in the Immunological Synapse and Functions in T Cells via Association with CD28
Researchers found association with CD28 to be essential for protein kinase C-θ (PKC-θ)-mediated downstream signaling and the differentiation of T helper type 2 cells and interleukin 17–producing helper T cells but not of T helper type 1 cells. [Nat Immunol] Abstract | Press Release

Mucosal Memory CD8+ T Cells Are Selected in the Periphery by an MHC Class I Molecule
Here researchers show that the nonclassical major histocompatibility complex (MHC) class I molecule thymus leukemia antigen, induced on dendritic cells interacting with CD8αα on activated CD8αβ+ T cells, mediated affinity-based selection of memory precursor cells. [Nat Immunol] Abstract

Mast Cell Interleukin-2 Production Contributes to Suppression of Chronic Allergic Dermatitis
Here researchers report that mast cell-derived interleukin-2 contributes to the suppression of chronic allergic dermatitis. [Immunity] Abstract

Evolutionarily Conserved Features Contribute to αβ T Cell Receptor Specificity
Here, researchers assess directly the evolutionary conservation of αβ T cell receptor specificity for major histocompatibility complex proteins. [Immunity] Abstract | Press Release

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation
Here, investigators report that interleukin-23 (IL-23) predominantly stimulated dermal γδ T cells to produce IL-17 that led to disease progression. [Immunity] Abstract

Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E
Here researchers show that an interleukin-17 (IL-17) cytokine family member, IL-17C, was induced in a T-helper 17 (Th17) cell-dependent autoimmune disease and was required for its pathogenesis. [Immunity] Abstract

N-Acetylglucosamine Inhibits T-Helper 1 (Th1) / T-Helper 17 (Th17) Responses and Treats Experimental Autoimmune Encephalomyelitis
Here scientists report that oral N-acetylglucosamine inhibits T-helper 1 and T-helper 17 responses and attenuates the clinical severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis when administered after disease onset. [J Biol Chem] Abstract | Press Release

The HIV/AIDS Vaccine Candidate MVA-B Administered as a Single Immunogen in Humans Triggers Robust, Polyfunctional, and Selective Effector Memory T Cell Responses to HIV-1 Antigens
Here, researchers describe the nature of T cell immune responses induced in healthy volunteers participating in a phase I clinical trial in Spain after intramuscular administration of three doses of the recombinant MVA-B-expressing monomeric gp120 and the fused Gag-Pol-Nef polyprotein of clade B. [J Virol] Abstract | Press Release

Inhibition of TLR8- and TLR4-Induced Type I IFN Induction by Alcohol Is Different from its Effects on Inflammatory Cytokine Production in Monocytes
Here scientists hypothesized that alcohol exposure modulates toll like receptor 8 (TLR8)- and toll like receptor 4 (TLR4)-ligand-induced monocyte activation and affects both type I interferon (IFN) and inflammatory cytokine induction. [BMC Immunol] Abstract | Press Release

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INDUSTRY NEWS

The Nobel Prize in Physiology or Medicine 2011
The Nobel Prize in Physiology or Medicine 2011 shall be divided, with one half jointly to Bruce A. Beutler and Jules A. Hoffmann for their discoveries concerning the activation of innate immunity and the other half to Ralph M. Steinman for his discovery of the dendritic cell and its role in adaptive immunity. [The Nobel Assembly at Karolinska Institutet] Press Release

Maryland Stem Cell Research Commission Issues 2012 Requests for Applications (RFAs) at Fourth Annual Stem Cell Symposium
Approximately 400 individuals attended the Fourth Annual Maryland Stem Cell Research Symposium presented by the Maryland Stem Cell Research Commission at Towson University. The Commission also released its 2012 Requests for Applications at the symposium. [Maryland Stem Cell Research Fund] Press Release

NeoStem’s Subsidiary, Progenitor Cell Therapy, and ImmunoCellular Therapeutics Enter Into a Manufacturing Agreement
Progenitor Cell Therapy, LLC (PCT) and ImmunoCellular Therapeutics, Ltd. (IMUC) announced that IMUC has retained the services of PCT to serve as the second manufacturing site to produce ICT-107, a dendritic cell-based vaccine targeting multiple tumor associated antigens for glioblastoma, for its Phase II clinical trial. [ImmunoCellular Therapeutics, Ltd.] Press Release

Second Multi-Target Collaboration with UCB Announced
Evotec AG announced that it has entered into a second multi year, multi target integrated drug discovery collaboration with UCB in the field of immunology. [Evotec AG] Press Release

Ono to Enter into License Agreements with Merck KGaA
Ono Pharmaceutical Co., Ltd. announced that the company signed two separate agreements with Merck KGaA on October 3, 2011 to out-license ONO-4641, a novel compound originally discovered and developed by Ono for the treatment of multiple sclerosis and to license for co-development and co-marketing Stimuvax® (candidate for product name) in Japan, a novel cancer immunotherapy, globally developed by Merck Serono. [Ono Pharmaceutical Co., Ltd.] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Immunogenicity Summit 2011
November 16-18, 2011
Bethesda, United States

Visit
our events page to see a complete list of events in the immune regulation community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 


Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 


Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Principal Scientist, Immune Disease (Takeda Pharmaceutical Company Limited)

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