Volume 3.36 | Sep 30

Immune Regulation News 3.36, September 30, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY

How Microbes Train Our Immune System: Gut Bacteria Coax T Cells to See Them as Friends
Microbes living in the colons of mice coax immune cells in their host to embrace them rather than spark an immune response, according to a study. [Press release from NatureNews discussing online prepublication in Nature] Press Release | Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Structural Basis of RNA Recognition and Activation by Innate Immune Receptor RIG-I
Here, to understand the synergy between the helicase and the repressor domains (RD) for RNA binding, and the contribution of ATP hydrolysis to retinoic-acid-inducible gene-I (RIG-I) activation, researchers determined the structure of human RIG-I helicase-RD in complex with double-stranded RNA and an ATP analogue. [Nature] Abstract | Press Release

Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection
Here, researchers report that during a murine chronic viral infection, interleukin-6 (IL-6) was produced by irradiation resistant cells in a biphasic manner, with late IL-6 being absolutely essential for viral control. [Science] Abstract

Innate Lymphoid Cells Promote Lung-Tissue Homeostasis After Infection with Influenza Virus
Here researchers identify a population of lung-resident innate lymphoid cells in mice and humans that expressed the alloantigen Thy-1 (CD90), interleukin 2 (IL-2) receptor α-chain (CD25), IL-7 receptor α-chain (CD127) and the IL-33 receptor subunit T1-ST2. [Nat Immunol] Abstract

Evolutionarily Conserved Features Contribute to αβ T Cell Receptor Specificity
Here, researchers assess directly the evolutionary conservation of αβ T cell receptor specificity for major histocompatibility complex proteins. [Immunity] Abstract

Integrating Autoimmune Risk Loci with Gene-Expression Data Identifies Specific Pathogenic Immune Cell Subsets
Researchers developed a statistical approach to identify potentially pathogenic cell types in autoimmune diseases by using a gene-expression data set of 223 murine-sorted immune cells from the Immunological Genome Consortium. [Am J Hum Genet] Abstract

Over-Activation of Plasmacytoid Dendritic Cell Inhibits Anti-Viral T-Cell Responses: A Model for HIV Immunopathogenesis
By depleting envelope-associated cholesterol to different degrees, investigators generated virions with reduced ability to activate plasmacytoid dendritic cells. [Blood] Abstract | Press Release

Mesenchymal Stem Cells Impair In Vivo T-Cell Priming by Dendritic Cells
Here researchers show that murine mesenchymal stem cells impair Toll-like receptor-4 induced activation of dendritic cells resulting in the inhibition of cytokines secretion, down-regulation of molecules involved in the migration to the lymph nodes, antigen presentation to CD4+ T cells, and cross-presentation to CD8+ T cells. [Proc Natl Acad Sci USA] Abstract

Heat Shock Protein 90 (HSP90) Contributes to Cytosolic Translocation of Extracellular Antigen for Cross-Presentation by Dendritic Cells
The results demonstrate the important role of HSP90 in cross-presentation by pulling endosomal antigen out into the cytosol. [Proc Natl Acad Sci USA] Abstract

In Vivo Accumulation of T Cells in Response to IL-2/Anti-IL-2 mAb Complexes Is Dependent in Part on the TNF Family Ligand 4-1BBL
Here investigators show that in vivo administration of IL-2/anti-IL-2 mAb (IL-2/mAb) complexes induces 4-1BB expression on both adoptively transferred antigen-specific memory CD8 T cells as well as on endogenous memory phenotype cells. [Immunol Cell Biol] Abstract

Dendritic Cells Regulate Natural Killer Cell Activation and Epithelial Injury in Experimental Biliary Atresia
Here, researchers use a model of virus-induced biliary atresia in newborn mice to trace the initiating pathogenic disease mechanisms to resident plasmacytoid and conventional dendritic cells. [Sci Transl Med] Abstract

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INDUSTRY NEWS

Novartis Receives Approval in Japan for Two Innovative Therapies, Gilenya® in MS and Ilaris® in CAPS
Novartis announced that it received regulatory approval in Japan from the Ministry of Health, Labor and Welfare for once-daily Gilenya (fingolimod) 0.5mg for the prevention of relapse and delay of progression of physical disability in adults with multiple sclerosis (MS), and for Illaris (canakinumab) subcutaneous injection 150mg, the first treatment for adults and children with cryopyrin-associated periodic syndrome (CAPS). [Novartis AG] Press Release

F-Star and Merck Serono to Collaborate in the Discovery and Development of Novel Targeted Biologics
F-Star GmbH announced that a research, license and commercialization agreement was signed with Merck Serono for the discovery of new antibody-derived therapeutics against inflammatory disease targets using F-Star’s Modular Antibody Technology. [F-Star GmbH] Press Release

NIH Director, Francis S. Collins, M.D., Ph.D., Recognizes 20 NIH Recipients of the Presidential Early Career Award for Scientists and Engineers (PECASE)
The NIH awardees will take their place along with 94 other highly accomplished scientists from a total of 16 federal agencies. [National Institutes of Health, United States] Press Release

Cancer Vaccine Collaborative Clinical Trials Network Appoints New Director, Expands Leadership
The Cancer Research Institute, Inc. and the Ludwig Institute for Cancer Research (LICR) announced that Jedd D. Wolchok, M.D., Ph.D., a clinician scientist and director of immunotherapy clinical trials at Memorial Sloan-Kettering Cancer Center and assistant member of LICR, has been named director of the Cancer Vaccine Collaborative. [Cancer Research Institute] Press Release

POLICY NEWS

International Society for Cellular Therapy (ISCT) Leads Roundtable with Major US Payors, Healthcare Providers and Industry to Initiate a Collaboration to Address Cell Therapy Product Reimbursement
In keeping with its mission to drive the commercialization of cell therapy products and advance global patient access, ISCT hosted its second event this year in its Commercial Development Series, this time focusing on the timely issue of reimbursement for cell therapy and regenerative medicine products in the US market. [International Society for Cellular Therapy, United States] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW IIR’s 7th Annual Cell Based Assays and Bioanalytical Method Development
October 3-5, 2011
Berkeley, United States

Visit
our events page to see a complete list of events in the immune regulation community.
JOB OPPORTUNITIES
Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 


Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 


Proteomics, Vascular Biology/Angiogenesis, or Immunology (St.Michael’s Hospital/University of Toronto)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut)

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