Volume 3.35 | Sep 23

Immune Regulation News 3.35, September 23, 2011
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY

Scientists Find Approach to Enhance and Prolong Immune Attack Against Tumor Cells
The study describes how stem cell-like T cells can trigger a prolonged immune attack against tumor cells by continuously generating killer T cells and regenerating themselves. [Press release from the National Institutes of Health discussing online prepublication in Nature Medicine] Press Release | Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Regulated Release of Nitric Oxide by Nonhematopoietic Stroma Controls Expansion of the Activated T Cell Pool in Lymph Nodes
Here researchers report that fibroblastic reticular cells and lymphatic endothelial cells inhibited T cell proliferation through a tightly regulated mechanism dependent on nitric oxide synthase 2. [Nat Immunol] Abstract

Chronic Virus Infection Enforces Demethylation of the Locus that Encodes PD-1 in Antigen-Specific CD8+ T Cells
By using human and murine systems of acute and chronic viral infections, researchers analyzed epigenetic regulation of PD-1 expression during CD8+ T cell differentiation. [Immunity] Abstract

Chemokine Nitration Prevents Intratumoral Infiltration of Antigen-Specific T Cells
Researchers describe a novel reactive nitrogen species-dependent posttranslational modification of chemokines that has a profound impact on leukocyte recruitment to mouse and human tumors. [J Exp Med] Abstract | Press Release

Host Type I IFN Signals Are Required for Antitumor CD8+ T Cell Responses Through CD8α+ Dendritic Cells
Results show that host type I IFNs are critical for the innate immune recognition of a growing tumor through signaling on CD8α+ dendritic cells. [J Exp Med] Abstract

Type I Interferon Is Selectively Required by Dendritic Cells for Immune Rejection of Tumors
Using mixed bone marrow chimeric mice, scientists demonstrate that type I interferon sensitivity selectively within the innate immune compartment is essential for tumor-specific T cell priming and tumor elimination. [J Exp Med] Abstract

Airborne Lipid Antigens Mobilize Resident Intravascular NKT Cells to Induce Allergic Airway Inflammation
In this study, researchers demonstrate that NKT cells constitutively accumulate and reside in the microvasculature of the mouse lung. [J Exp Med] Abstract

DC Mobilization from the Skin Requires Docking to Immobilized CCL21 on Lymphatic Endothelium and Intralymphatic Crawling
Researchers studied how dendritic cells (DCs) in live mice respond to skin inflammation, transmigrate through lymphatic endothelium, and propagate in initial lymphatics. [J Exp Med] Abstract

A Subclass of Acylated Anti-Inflammatory Mediators Usurp Toll-Like Receptor 2 to Inhibit Neutrophil Recruitment Through Peroxisome Proliferator-Activated Receptor γ
Here, investigators report that the di-acylated TLR2 ligand lipoteichoic acid can directly inhibit neutrophil recruitment in vivo. [Proc Natl Acad Sci USA] Abstract | Press Release

Hepatocyte Entry Leads to Degradation of Autoreactive CD8 T Cells
By investigating the site in which autoreactive T cells are tolerized, researchers identify a unique mechanism of peripheral deletion in which naïve autoreactive CD8 T cells are rapidly eliminated in the liver after intrahepatic activation. [Proc Natl Acad Sci USA] Abstract | Press Release

A Plasmablast Biomarker for Nonresponse to Antibody Therapy to CD20 in Rheumatoid Arthritis
Here, researchers tested the hypothesis that quantitative mRNA assays for B lineage cells in blood could serve as baseline predictors of therapeutic response to B cell depletion therapy in subjects with rheumatoid arthritis. [Sci Transl Med] Abstract

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SCIENCE NEWS

Virus a Potential Future Cancer Medicine
The new findings show that the vesicular stomatitis virus both kills cancer cells and stops the expression of the molecules which certain types of cancer cells produce to hide from the immune system. [University of Copenhagen] Press Release

Gene Therapy May Thwart HIV
The studies attempt to make the immune system resistant to HIV by crippling a receptor, known as CCR5, on T cells that the virus uses during the infection process. [Press release from ScienceNOW discussing research presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago] Press Release

INDUSTRY NEWS

The Centre for Drug Research and Development and the National Research Council Canada to Collaborate on New Cancer Therapeutics
The Centre for Drug Research and Development and the National Research Council Canada Biotechnology Research Institute announced that they have entered into a Preferred Collaboration Agreement to develop new antibody-based cancer therapeutics. [The Centre for Drug Research and Development] Press Release

Adaptimmune Announces New Board Appointments as Clinical Programmes Get Underway
Adaptimmune is strengthening its Board following the opening of three pilot cancer trials and an HIV trial earlier this year. [Adaptimmune] Press Release

Biochemist, Brenda L. Bass, Ph.D., Wins NIH Pioneer Award to Study Elusive RNA Molecule’s Link to Inflammatory Diseases
Bass is among 13 scientists nationwide to receive the prestigious 2011 award, which comes with $2.5 million in funding or $500,000 annually for five years. [University of Utah Heath Care] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 2011 Improving Immunohistochemistry Discussion Forum
October 28, 2011
London, United Kingdom

Visit
our events page to see a complete list of events in the immune regulation community.
JOB OPPORTUNITIES
Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 


Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 


Research and Development Technologist (STEMCELL Technologies) 


Proteomics, Vascular Biology/Angiogenesis, or Immunology (St.Michael’s Hospital/University of Toronto)

Postdoctoral Position (Izmir Katip Celebi University)

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