Volume 3.33 | Sep 9

Immune Regulation News 3.33, September 9, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY

The Inflammasome Adaptor ASC Regulates the Function of Adaptive Immune Cells by Controlling Dock2-Mediated Rac Activation and Actin Polymerization
Here researchers demonstrate that ASC has an inflammasome-independent, cell-intrinsic role in cells of the adaptive immune response. [Nat Immunol] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity
Animal studies demonstrated that intravenous immunization was critical for inducing a high frequency of Plasmodium falciparum sporozoite-specific CD8+, interferon-γ–producing T cells in the liver (nonhuman primates, mice) and conferring protection (mice). [Science] Abstract

Human Cytomegalovirus MicroRNA miR-US4-1 Inhibits CD8+ T Cell Responses by Targeting the Aminopeptidase ERAP1
The findings identify a previously unknown viral microRNA–based cytotoxic T lymphocyte-evasion mechanism that targets a key step in the major histocompatibility complex class I antigen-processing pathway. [Nat Immunol] Abstract

The Helicase DDX41 Senses Intracellular DNA Mediated by the Adaptor STING in Dendritic Cells
Here investigators report the identification of DDX41, a member of the DEXDc family of helicases, as an intracellular DNA sensor in myeloid dendritic cells. [Nat Immunol] Abstract

Invariant Natural Killer T Cells Recognize Glycolipids from Pathogenic Gram-Positive Bacteria
Here researchers show that natural killer T cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae and group B Streptococcus. [Nat Immunol] Abstract

A Recombinant Mycobacterium smegmatis Induces Potent Bactericidal Immunity Against Mycobacterium tuberculosis
Analysis of the adaptive immune responses indicated that the highly protective bactericidal immunity elicited by IKEPLUS was dependent on CD4+ memory T cells and involved a distinct shift in the pattern of cytokine responses by CD4+ cells. [Nat Med] Abstract | Press Release

Increased Sensitivity of Antigen-Experienced T Cells Through the Enrichment of Oligomeric T Cell Receptor Complexes
Through biochemistry and electron microscopy, researchers showed that previously stimulated and memory T cells have more and larger T cell receptor oligomers at the cell surface than their naive counterparts. [Immunity] Abstract

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production
To systematically investigate innate immune signaling networks regulating production of type I interferon, researchers analyzed protein complexes formed after microbial recognition. [Immunity] Abstract

Protective Antiviral Antibody Responses in a Mouse Model of Influenza Virus Infection Require TACI
Here, researchers have identified a critical role for extrinsic cytokine signals in the survival of respiratory tract antibody-secreting cells in a mouse model of influenza infection. [J Clin Invest] Abstract | Press Release

The Cyclin Dependent Kinase Inhibitor p21 Is Essential for Resolution of Murine Inflammatory Arthritis via its C-Terminal Domain
Here, investigators sought to determine the role and mechanism of p21-mediated suppression of experimental inflammatory arthritis. [Arthritis Rheum] Abstract | Press Release

Natural Killer Cells in Free-Living Mus musculus Have a Primed Phenotype
The findings indicate a high degree of pre-activation of natural killer (NK) cells of free-living mice, indicating a strong environmental impact on NK cells, which may be highly relevant for interpretation of studies in the mouse model. [Mol Ecol] Abstract | Press Release

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INDUSTRY NEWS

Phase IIa Study of Selective Oral JAK3 Inhibitor VX-509 Showed Significant Improvements in Signs and Symptoms of Rheumatoid Arthritis
Vertex Pharmaceuticals Incorporated announced that treatment with the investigational selective oral JAK3 inhibitor VX-509 in a Phase IIa trial resulted in substantial and statistically significant improvements in multiple measurements of rheumatoid arthritis activity. [Vertex Pharmaceuticals Incorporated] Press Release

Toyama Chemical and Eisai Submit Marketing Authorization Application for Anti-Rheumatic Agent T-614
Toyama Chemical Co., Ltd. and Eisai Co., Ltd. announced that they have submitted a marketing authorization application for T-614 (iguratimod), an anti-rheumatic agent being jointly developed in Japan by the two companies. [Eisai Co., Ltd.] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Phacilitate Vaccine Forum Singapore 2011
September 19-21, 2011
Singapore

Visit
our events page to see a complete list of events in the immune regulation community.

JOB OPPORTUNITIES
Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 


Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 


Research and Development Technologist (STEMCELL Technologies) 


Proteomics, Vascular Biology/Angiogenesis, or Immunology (St.Michael’s Hospital/University of Toronto)

PhD Scholarship (Tasmania University)

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