Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Upregulation of HLA-II Related to LAG-3+ CD4+ T Cell Infiltration Is Associated with Patient Outcome in Human Glioblastoma

[Cancer Science] Scientists investigated the expression and regulation of human leukocyte antigen-II in human glioblastoma samples and the correlation with LAG-3+CD4+ T cell infiltration.

Transmembrane TNF-TNFR2 Signaling as a Critical Immunoregulatory Node in Pancreatic Cancer

[Oncoimmunology] Researchers described that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-associated fibroblasts and T cell dysfunction – two hallmarks of therapeutic resistance.

A Single-Agent Fusion of Human IL-2 and Anti-IL-2 Antibody That Selectively Expands Regulatory T Cells

[Communications Biology] Investigators discovered an anti-human IL-2 antibody and engineer a covalently-linked single-agent fusion of human IL-2 and its antibody that selectively expands Treg cells and exhibits superior disease control activity in animal models of ulcerative colitis and systemic lupus erythematosus, with proper safety profile and good developability.

Mi-2β Promotes Immune Evasion in Melanoma by Activating EZH2 Methylation

[Nature Communications] Scientists identified Mi-2β as a key melanoma-intrinsic effector regulating the adaptive anti-tumor immune response. Studies in genetically engineered mouse melanoma models indicated that loss of Mi-2β rescues the immune response to immunotherapy in vivo.

Impact of NDUFAF6 on Breast Cancer Prognosis: Linking Mitochondrial Regulation to Immune Response and PD-L1 Expression

[Cancer Cell International] Researchers explored the expression and functional significance of NDUFAF6 in breast cancer using various databases and experimental models.

T Cell Help in the Tumor Microenvironment Enhances Rituximab-Mediated NK Cell ADCC

[Blood] Investigators conducted studies using a novel mouse model and clinical correlative analysis to assess whether T cell help contributed to rituximab-mediated nature killer cell antibody-dependent cellular cytotoxicity in the tumor microenvironment in vivo.

Dioscin Alleviates Aplastic Anemia through Regulatory T Cells Promotion

[Hematology] Scientists looked into the effect of Dioscin on the functions of CD4+ CD25+ Tregs in the AA mouse model and explored its underlying mechanism.

FCRL3 Expression Is Upregulated and Closely Correlates with TIGIT Expression in Regulatory T Cells of Patients with Systemic Lupus Erythematosus

[European Journal Of Immunology] Using data from single-cell RNA sequencing and flow cytometry, we initially examined the expression of FCRL3, finding it to be elevated and positively associated with TIGIT expression in the regulatory T cells of patients with systemic lupus erythematosus.

Comprehensive Assessment of Regulatory T Cells-Related Scoring System for Predicting the Prognosis, Immune Microenvironment and Therapeutic Response in Hepatocellular Carcinoma

[Aging] Investigators constructed a novel Tregs-associated biomarker for the prediction of tumour immune microenvironment, clinical outcomes, and individualised treatment in hepatocellular carcinoma.

Beyond T Cell Exhaustion: TIM-3 Regulation of Myeloid Cells

[Science Immunology] Scientists review emerging evidence demonstrating unexpected roles for T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) as a key regulator of myeloid cell function.

Combining TIGIT Blockage with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Anti-Tumor Immunity

[Cancer Discovery] Investigators showed that crosstalk between granulocytes and T cells was central to shaping an immunosuppressive microenvironment. They identified the PD-1 and TIGIT signaling axes and the pro-inflammatory cytokine IL1b as central players in the interactions between granulocytes and T cells.

CD8+ T Cell Priming That Is Required for Curative Intratumorally Anchored Anti-4-1BB Immunotherapy Is Constrained by Tregs

[Nature Communications] Researchers reported the development of a tumor-anchored ɑ4-1BB agonist, which consisted of a ɑ4-1BB antibody fused to the collagen-binding protein leukocyte associated immunoglobulin like receptor (LAIR).

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.

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