Volume 3.09 | Mar 11

Immune Regulation News 3.04, February 4, 2011.

     In this issue: Science News | Current Publications | Industry News | Policy News | Events

Researchers Discover How Cancer Cheats Immune System
The groundbreaking discovery identifies for the first time a commonly-occurring gene fusion as a cause in primary mediastinal B-cell
lymphoma, and as one of only a handful of times a specific gene has been implicated in the development of Hodgkin lymphoma. [Press release from the BC Cancer Agency discussing online prepublication in Nature]



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For First Time, Scientists Show an HIV Vaccine Impacts the Genetic Makeup of the Virus
An AIDS vaccine tested in people, but found to be ineffective, influenced the genetic makeup of the virus that slipped past. The findings suggest new ideas for developing HIV vaccines. [Press release from the University of Washington discussing online prepublication in Nature Medicine]

Making Viruses Pass for ‘Safe’
Researchers have created a lentiviral vector that expresses CD47, the “marker of self” protein, on its surface. The protein gives cells a free license from macrophages. [Press release from ScienceDaily discussing research presented at the 55th Annual Biophysical Society Meeting in Baltimore, MD]

New Instrument for Analyzing Viruses
Scientists in Israel and California have developed an instrument for rapidly analyzing molecular interactions that take place between viruses and the cells they infect. [Press release from Newswise discussing research presented at the 55th Annual Biophysical Society Meeting in Baltimore, MD]

New Clues to Help Patients With Immune Deficiency Disease
Infection researchers have uncovered a new disease mechanism in patients with Chronic Granulomatous Disease (CGD) in an international clinical collaboration with the Children’s Hospital in Zurich. [Press release from Umeå University discussing online prepublication in the Journal of Allergy and Clinical Immunology]

Journal of Clinical Investigation Publishes Data Demonstrating Enhanced Antitumor Efficacy of Second Generation DeCIDe(TM) Technology
Bellicum Pharmaceuticals, Inc. announced the publication of studies comparing AP1903-activated iMyD88/CD40-transduced dendritic cells (DCs)
to conventionally matured DCs, in the April 2011 issue of The Journal of Clinical Investigation. [Press release from Bellicum
Pharmaceuticals, Inc. discussing online prepublication in The Journal of Clinical Investigation]

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MHC Class II Transactivator CIITA Is a Recurrent Gene Fusion Partner in Lymphoid Cancers
Here researchers show a highly expressed gene fusion involving the major histocompatibility complex (MHC) class II transactivator CIITA (MHC2TA) in KM-H2 cells. [Nature]

Genetic Impact of Vaccination on Breakthrough HIV-1 Sequences From the STEP Trial
To determine whether the vaccine exerted selective T cell pressure on breakthrough viruses, researchers identified potential T cell epitopes in the founder sequences and compared them to epitopes in the vaccine. [Nat Med]

The Transcription Factors Blimp-1 and IRF4 Jointly Control the Differentiation and Function of Effector Regulatory T (Treg) Cells
Here researchers demonstrate that expression of the transcription factor Blimp-1 defined a population of Treg cells that localized mainly to mucosal sites and produced IL-10. [Nat Immunol]

Paired Immunoglobin-like Receptor-B Regulates the Suppressive Function and Fate of Myeloid-Derived Suppressor Cells (MDSC)
Herein, researchers investigate the potential function of paired immunoglobulin-like receptor B (PIR-B), also known as leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB3) in MDSC differentiation, and its role in tumor-induced immunity. [Immunity]

A Molecular Basis for NKT Cell Recognition of CD1d-Self-Antigen
Here, researchers have characterized the antigen receptor for natural killer T cell (NKT TCR) recognition of CD1d molecules loaded with natural self-antigens and report the 2.3 Å resolution structure of an autoreactive NKT TCR-phosphatidylinositol-CD1d complex. [Immunity]

A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells
Here researchers have described natural killer T cell receptor (NKT TCR) fine specificity against several closely related antigens, termed altered glycolipid ligands, which differentially stimulate NKT cells. [Immunity]

A Composite MyD88/CD40 Switch Synergistically Activates Mouse and Human Dendritic Cells (DCs) for Enhanced Antitumor Efficacy
Here, researchers have engineered a drug-inducible, composite activation receptor for DCs (referred to herein as DC-CAR) comprising the TLR adaptor MyD88, the CD40 cytoplasmic region, and 2 ligand-binding FKBP12 domains. [J Clin Invest]

Restoration of Anti-Aspergillus Defense by Neutrophil Extracellular Traps (NETs) in Human Chronic Granulomatous Disease (CGD) After Gene Therapy is Calprotectin-Dependent
The objective of this study was to determine the antifungal agent and mechanism responsible for reconstitution of Aspergillus growth inhibition within NETs after complementation of NADPH oxidase function by gene therapy for CGD. [J Allergy Clin Immunol]

Nonredundant Roles of IL-10 and TGF-Beta in Suppression of Immune Responses to Hepatic AAV-Factor IX Gene Transfer
In this study, researchers examined the roles of immune suppressive cytokines interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) in the development of tolerance to human coagulation factor IX (hF.IX). [Mol Ther]  


Cancer Immunotherapy Consortium 2011 Colloquium – Scheduling and Dosing for Combination Therapy
This year’s meeting, titled “Schedule and Dose for Combination Therapy,” will include a series of plenary lectures from academic and industry leaders in tumor immunology and immunotherapy. [Cancer Research Institute Press Release]

Dendreon Expands Launch of PROVENGE
Dendreon Corporation announced that the U.S. Food and Drug Administration (FDA) approved the remainder of its New Jersey manufacturing facility, allowing the company to significantly increase the availability of PROVENGE® (sipuleucel-T). [Dendreon Corporation Press Release]

Adaptimmune Announces Launch of US Subsidiary and Appointment of Gwen Binder-Scholl as VP of Operations
Adaptimmune Limited announced that it has launched a US subsidiary, Adaptimmune LLC, located in Philadelphia, and appointed Dr Gwen Binder-Scholl as Vice President of Operations of the new company. [Adaptimmune Limited Press Release]


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Immunology 2011: The American Association of Immunologists 98th Annual Meeting
May 13-17, 2011
San Francisco, United States

our events page to see a complete list of events in the immune regulation community.

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Assistant Professor (University of Pittsburgh School of Medicine, Center for Cellular and Molecular Engineering)

Scientist – Pathology (Immunology) (Genentech)

Scientist – Human Monoclonal Antibody Discovery (Arsanis Biosciences)

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