Volume 3.00 | Jan 7

Immune Regulation News 3.00, January 7, 2011.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


The Transcription Factor STAT3 Is Required for T Helper 2 Cell Development  ShareThis
Signal transducer and activator of transcription (STAT) 6 is required for the development of T helper 2 (Th2) cells, whereas STAT3 promotes differentiation of Th17 and follicular helper T cell subsets. Researchers demonstrated that STAT3 was also activated during Th2 cell development and was required for the expression of Th2 cell-associated cytokines and transcription factors. [Immunity]

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Accurate Interpretation of Antinuclear Antibodies Test Key to Confirming Autoimmune Disease
Researchers from Brazil have now uncovered distinguishing characteristics of the antinuclear antibodies test in healthy individuals and patients with autoimmune disease, reducing the likelihood of an erroneous autoimmune disorder diagnosis. [Press release from ScienceDaily discussing online prepublication in Arthritis & Rheumatism]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens
The major source of tumor antigens is dead tumor cells, but little is known about how antigen-presenting cells in draining lymph nodes acquire and crosspresent these antigens. Here, researchers show that CD169+ macrophages phagocytose dead tumor cells transported via lymphatic flow and subsequently crosspresent tumor antigens to CD8+ T cells. [Immunity]

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion
Here, researchers show that human blood CXCR5+CD4+ T cells share functional properties with T follicular helper cells and appear to represent their circulating memory compartment. [Immunity]

A Highly Tilted Binding Mode by a Self-Reactive T Cell Receptor Results in Altered Engagement of Peptide and MHC
Self-reactive T cells that escape elimination in the thymus can cause autoimmune pathology, and it is therefore important to understand the structural mechanisms of self-antigen recognition. Researchers report the crystal structure of a T cell receptor from a patient with relapsing-remitting multiple sclerosis that engages its self-peptide-major histocompatibility complex ligand in an unusual manner. [J Exp Med]

Acquisition and Presentation of Follicular Dendritic Cell-Bound Antigen by Lymph Node-Resident Dendritic Cells
In this study, researchers show that follicular dendritic cell (DC)-retained antigens are continually sampled by lymph node-resident DCs for presentation to CD8 T cells. [J Exp Med]

IL-27 Promotes T Cell-Dependent Colitis through Multiple Mechanisms
Because the role of Interleukin-27 (IL-27) in human and experimental mouse colitis is controversial, researchers studied the consequences of Il27ra deletion in the mouse T cell transfer model of colitis and unexpectedly discovered a proinflammatory role of IL-27. [J Exp Med]

CD137 Stimulation Enhances the Anti-Lymphoma Activity of Anti-CD20 Antibodies
In a syngeneic murine lymphoma model and in a xenotransplanted human lymphoma model, sequential administration of anti-CD20 monoclonal antibody (mAb) followed by anti-CD137 mAb has potent anti-lymphoma activity in vivo. These results support a novel, sequential antibody approach against B cell malignancies by targeting first the tumor and then the host immune system. [Blood]

T Helper Cell Type 2 (Th2) Memory T Cell-Potentiating Cytokine IL-25 Has the Potential to Promote Angiogenesis in Asthma
Researchers hypothesized that IL-25 stimulates local angiogenesis in the asthmatic bronchial mucosa. Immunoreactive IL-25+, IL-25R+, and CD31+ (endothelial) cells in sections of bronchial biopsies from asthmatics and controls were detected by immunohistochemistry. [Proc Natl Acad Sci USA]

T Cell Receptor Ligation Induces Distinct Signaling Pathways in Naïve vs. Antigen-Experienced T Cells
Naïve T lymphocytes display weaker and slower responses than antigen-experienced cells for reasons that are not well understood. Here, researchers show that T-cell receptor stimulation induces distinct ERK and p38 phosphorylation patterns in naïve and antigen-experienced human T cells, and that these contribute to the differential responses shown by these cells. [Proc Natl Acad Sci USA]

Pattern On the Antinuclear Antibody-HEp-2 Test Is a Critical Parameter for Discriminating Antinuclear Antibody-Positive Healthy Individuals and Patients with Autoimmune Rheumatic Diseases
The purpose of the study was to identify features of antinuclear antibody (ANA)-HEp-2 test results that discriminate ANA-positive healthy individuals and patients with autoimmune rheumatic diseases. [Arthritis Rheum]



SYMPHOGEN Raises 100 Million Euros in Private Equity Round
Symphogen, a private biopharmaceutical company developing superior antibody therapeutics (monoclonal, monoclonal mixtures and polyclonal) to treat cancer, infectious and autoimmune diseases, announced that it closed a 100 million euro placement of Preferred Stock to a group of investors. [Symphogen Press Release]

VBL Therapeutics to Present at 29th Annual J.P. Morgan Healthcare Conference
VBL Therapeutics, a clinical-stage biotechnology company committed to the development of novel treatments for immune-inflammatory diseases and cancer, announced that Dror Harats, M.D., chief executive officer, will present at the 29th Annual J.P. Morgan Healthcare Conference. [VBL Therapeutics Press Release]

Particle Sciences Develops Wax Nanoparticles that Enhance Immune Response to Antigens
Particle Sciences Inc. (PSI), a leading pharmaceutical CRO has formulated a series of wax nanoparticles that, when coupled with an antigen, enhanced its immunogenicity, increasing both systemic and the mucosal immune response. [Particle Sciences Inc. Press Release]

Amgen and Xencor Enter Option Deal to Co-Develop Xencor’s Novel Antibody for Autoimmune Diseases
Amgen and Xencor, Inc. announced that they will collaborate to develop XmAb(R)5871, an Fc- engineered monoclonal antibody dually targeting CD19 and CD32b. [Amgen Press Release]

Spirogen Ltd. Announces a Research Collaboration and License Agreement With Genentech for the Discovery and Development of Antibody Drug Conjugates
Spirogen Ltd. a leading oncology-focused company developing DNA sequence targeted agents, announced a multi-year research collaboration and license agreement with Genentech, a member of the Roche Group. [PR Newswire]

SERVIER Announces Joint Development and Commercialization with XOMA on Novel Therapeutics for Orphan Disease
Servier and XOMA Ltd., a leader in the discovery and development of therapeutic antibodies, announced the signing of an agreement to jointly develop and commercialize XOMA 052, XOMA’s anti-inflammatory drug candidate, in multiple indications. [Servier Press Release]


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