Volume 2.47 | Dec 10

Immune Regulation News 2.47, December 10, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Vanderbilt Study Explains Disproportionate Illness and Deaths Among Young Adults During H1N1 Pandemic Flu  ShareThis
The study’s findings suggest people are made critically ill, or even killed, by their own immune response. [Press release from Vanderbilt University Medical Center discussing online prepublication in Nature Medicine]

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SCIENCE NEWS

Some Stem Cells Protect TB Bacteria: Study
Certain stem cells protect tuberculosis (TB) bacteria from being destroyed, which explains why TB can lie dormant for years or even decades in the human body, researchers said. [Press release from Reuters discussing online prepublication in the Proceedings of the National Academy of Sciences]

There’s a New ‘Officer’ in the Infection Control Army
Scientists have identified a previously unrecognized step in the activation of infection-fighting white blood cells, the main immunity troops in the body’s war on bacteria, viruses and foreign proteins. [Press release from Johns Hopkins Medicine discussing online prepublication in Molecular Cell]

Aggressive Blood Cancers: Adoptive Transfer of Regulatory T Cell-Depleted Donor T Helper Type 1 and T Helper Type 2 Cells Safely Accelerates Alloengraftment after Low-Intensity Chemotherapy
Researchers conducted a clinical trial to evaluate the effectiveness of infusing cultured donor immune cells known as “T-rapa” cells after stem cell transplantation into patients being treated for blood-related cancers. [Press release from ScienceDaily discussing research presented at the 52nd Annual Meeting of the American Society of Hematology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Severe Pandemic 2009 H1N1 Influenza Disease due to Pathogenic Immune Complexes
The observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics. [Nat Med]

The Enhancer HS2 Critically Regulates GATA-3-Mediated Il4 Transcription in T Helper Type 2 Cells
Researchers identify the DNase I-hypersensitive site 2 (HS2) element located in the second intron of the interleukin 4 locus (Il4) as a critical enhancer strictly controlled by GATA-3 binding. [Nat Immunol]

Control of the Differentiation of Regulatory T Cells and T Helper Type 17 Cells by the DNA-Binding Inhibitor Id3
Scientists show that deletion of the DNA-binding inhibitor Id3 resulted in the defective generation of Foxp3+ regulatory T cells. [Nat Immunol]

Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8+ T Cell Accrual
Investigators conclude that plasmacytoid dendritic cells mediate early antiviral type I interferon responses and influence the accrual of virus-specific natural killer (NK) or CD8+ T cells in a virus-dependent manner. [Immunity]

Antiphospholipid Antibodies Promote Leukocyte-Endothelial Cell Adhesion and Thrombosis in Mice by Antagonizing eNOS via Beta-2GPI and apoER2
In antiphospholipid syndrome, antiphospholipid antibodies binding to beta-2 glycoprotein I (beta-2GPI) induce endothelial cell-leukocyte adhesion and thrombus formation via unknown mechanisms. Here, scientists show that in mice both of these processes are caused by the inhibition of the endothelial isoform of NOS. [J Clin Invest]

Mycobacterium tuberculosis Evades Host Immunity by Recruiting Mesenchymal Stem Cells
Scientists demonstrate that Mycobacterium tuberculosis suppresses T-lymphocyte responses by recruiting mesenchymal stem cells to the site of infection. [Proc Natl Acad Sci U S A]
 
Genetic Immunization in the Lung Induces Potent Local and Systemic Immune Responses
Genetic immunization in the lung offers a powerful platform approach to generating protective immune responses against respiratory pathogens. [Proc Natl Acad Sci U S A]

Tumor Ablation by Gene-Modified T Cells in the Absence of Autoimmunity
To determine whether gene-modified T cells could induce antitumor effects without associated autoimmune pathology, scientists assessed the ability of T cells expressing an anti-Her-2 chimeric receptor to eradicate tumor in Her-2 transgenic mice that express human Her-2 as a self-antigen in brain and mammary tissues. [Cancer Res]

Potent Antirheumatic Activity of a New DNA Vaccine Targeted to B7-2/CD28 Costimulatory Signaling Pathway in Autoimmune Arthritis
Scientists show a single intramuscular injection of their novel targeted DNA vaccine encoding Pseudomonas exotoxin A and costimulatory molecule B7-2 without autoantigens in a collagen-induced arthritis model simultaneously increased CD4+CD25+ regulatory T and CD8+CD28-suppressor T cells and selectively decreased autoreactive CD4+CD28+ T helper type 1 cells. [Hum Gene Ther]

CD8+ T Cell Activation Predominate Early Immune Responses to Hypercholesterolemia in Apoe-/- Mice
Researchers assessed immune responses to hypercholesterolemia induced by feeding Apoe-/- mice a high-fat diet for 4 or 8 weeks. [BMC Immunol]



INDUSTRY NEWS

GlaxoSmithKline and Human Genome Sciences Announce FDA Extension of Benlysta® PDUFA Target Date to 10th March 2011
GlaxoSmithKline PLC and Human Genome Sciences, Inc. announced that the U.S. Food and Drug Administration (FDA) has extended the Prescription Drug User Fee Act target date for its priority review of the Biologics License Application for Benlysta® as a potential treatment for systemic lupus erythematosus from 9th December 2010 to 10th March 2011. [GlaxoSmithKline PLC Press Release]

Biocon May Start Therapeutic Cancer Vaccine Trials Next Year
Biocon Limited, in collaboration with a US-based research company, is working on creating a “therapeutic vaccine” that will help the body activate the immune system to fight cancer on its own. [Biocon Ltd. Press Release]

SuppreMol Receives Public Research Funding to Advance its Lead Project SM101 into SLE as Further Indication
SuppreMol GmbH announced it has been awarded research funding by the German Federal Ministry of Education and Research. [SuppreMol GmbH Press Release]

Molecular Diagnostics Platform Will Enable Better Monitoring of Immune System in Human Disease
Sequenta, Inc., a molecular diagnostics platform company focused on immune system profiling, announced that the company has raised $13 million in funding. [Sequenta, Inc. Press Release]

Accentia Biopharmaceuticals Announces Strategic Agreement with Baxter
Accentia Biopharmaceuticals, Inc. announced a strategic agreement with Baxter Healthcare Corporation to provide Accentia with the exclusive, worldwide right to purchase Baxter’s cyclophosphamide, which is marketed under the brand name Cytoxan®, for the treatment of designated autoimmune diseases including multiple sclerosis. [Accentia Biopharmaceuticals, Inc. Press Release]



POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)



EVENTS (Listed by Date)

The 50th Midwinter Conference of Immunologists at Asilomar
January 22-25, 2011
Pacific Grove, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Phacilitate 9th Annual North American Vaccine Forum
January 24-26, 2011
Washington, D.C., United States

AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer
January 30-February 2, 2011
San Diego, United States

Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity
February 12-17, 2011
Santa Fe, United States

Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
February 15-20, 2011
Taos, United States

Lorne Infection and Immunity Conference 2011
February 16-18, 2011
Lorne, Australia

18th Conference on Retroviruses and Opportunistic Infections (CROI 2011)
February 27-March 2, 2011
Boston, United States

Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany

PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States

The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting
March 18-22, 2011
San Francisco, United States

Microbiota and Mucosal Immunology: The Interface in Health and Disease
April 14-16, 2011
San Francisco, United States

GTCbio 2nd International Conference on Cancer Immunotherapy & Immunomonitoring
May 2-5, 2011
Budapest, Hungary

World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-22, 2011
Seattle, United States

Gordon Research Conference: Viruses & Cells
May 29-June 3, 2011
Lucca (Barga), Italy

DNA Vaccines 2011
July 12-14, 2011
San Diego, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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