Volume 2.46 | Dec 3

Immune Regulation News 2.46, December 3, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation  ShareThis
Researchers showed here that conditional inactivation of Hes1 , a well-characterized Notch target gene, in adult murine bone marrow cells severely impaired T cell development without affecting other Notch-dependent hematopoietic lineages such as marginal zone B cells. [Immunity]

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SCIENCE NEWS

Journal of Experimental Medicine Publishes New Dynavax Findings on the Role of TLRS in Cutaneous Lupus
Dynavax Technologies Corporation reported new data that suggests an important role of the key innate immune receptors TLR7 and TLR9 in cutaneous lupus and related skin conditions. [Press release from the Dynavax Technologies Corporation discussing online prepublication in the Journal of Experimental Medicine]

Mayo Researchers Find Drug-Resistant HIV Patients With Unimpaired Immune Cells
Researchers have shown why, in a minority of HIV patients, immune function improves despite a lack of response to standard anti-retroviral treatment. In these cases, researchers say, the virus has lost its ability to kill immune cells. [Press release from the Mayo Clinic discussing online prepublication in PLoS Pathogens]

Adipose Tissue Produces Cells Involved in Immune Response
Researchers isolated a population of hematopoietic stem cells in adipose tissue capable of differentiating into mast cells. [Press release from PhysOrg discussing online prepublication in Stem Cells]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Autoimmune Skin Inflammation is Dependent on Plasmacytoid Dendritic Cell Activation by Nucleic Acids via TLR7 and TLR9
Recognition of endogenous DNA and RNA by cells expressing TLR7 and TLR9 is an important contributor to the pathogenesis of systemic lupus erythematosus and has been suggested to contribute to cutaneous lupus and to a group of related inflammatory skin diseases termed interface dermatitis. Researchers have developed a mouse model of TLR7- and TLR9-dependent skin inflammation using tape stripping. [J Exp Med]

IL-27 Supports Germinal Center Function by Enhancing IL-21 Production and the Function of T Follicular Helper Cells
Researchers show that the heterodimeric cytokine IL-27 is critical for the function of T follicular helper cells and for normal and pathogenic germinal center responses. [J Exp Med]

Blockade of Osteopontin Reduces Alloreactive CD8+ T Cell-Mediated Graft-Versus-Host Disease
This study demonstrates for the first time, the critical effect of osteopontin (OPN) in the initiation and persistence of CD8+ T cell-mediated graft-versus-host disease (GVHD), and validates OPN as a potential target in GVHD prevention. [Blood]

Inflammation-Induced Tumorigenesis in the Colon is Regulated by Caspase-1 and NLRC4
Using the azoxymethane and dextran sodium sulfate colitis-associated colorectal cancer model, researchers show that caspase-1-deficient (Casp1-/-) mice have enhanced tumor formation. [Proc Natl Acad Sci USA]

Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors
In this study, researchers asked whether mast cells present in mice adipose tissue could derive from hematopoietic stem/progenitor cells identified in the tissue. [Stem Cells]

Patients with Discordant Responses to Antiretroviral Therapy Have Impaired Killing of HIV-Infected T Cells
Researchers have studied the circumstance of HIV-infected patients in whom antiretroviral therapy results in immunologic benefit, despite virologic failure. [PLoS Pathog]


INDUSTRY NEWS

Hycult Biotech B.V. Announces Formation of Hycult Biotech Inc. to Serve the Innate Immune Market Segment in the Americas
Hycult Biotechnology bv announced the formation of Hycult Biotech Inc. a wholly owned subsidiary located in Plymouth Meeting, PA. The Company specializes in the development, manufacture and commercialization of antibodies, antibody based products and more specifically immunoassays for innate immunity and directly related fields. [Hycult Biotech B.V. Press Release]

Immune Response Modifiers from 3M Available for the Pharmaceutical Industry
3M announces the availability of immune response modifier compounds for nonvaccine use in the pharmaceutical industry. The toll-like receptor (TLR) compounds, that activate through TLR7 and TLR8, show promise for the treatment of conditions including cancer, dermatologic diseases and atopic diseases, such as allergy and asthma. [Businesswire]


POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


EVENTS (Listed by Date)

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

Safety Symposium organized by the NIH RAC and Co-hosted by CliniGene: Retroviral and Lentiviral Vectors for Long-Term Gene Correction: Clinical Challenges in Vector and Trial Design
December 9-10, 2010
Bethesda, United States

The 50th Midwinter Conference of Immunologists at Asilomar
January 22-25, 2011
Pacific Grove, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Phacilitate 9th Annual North American Vaccine Forum
January 24-26, 2011
Washington, D.C., United States

AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer
January 30-February 2, 2011
San Diego, United States

Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity
February 12-17, 2011
Santa Fe, United States

Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
February 15-20, 2011
Taos, United States

Lorne Infection and Immunity Conference 2011
February 16-18, 2011
Lorne, Australia

18th Conference on Retroviruses and Opportunistic Infections (CROI 2011)
February 27-March 2, 2011
Boston, United States

NEW  Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany

NEW PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States

The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting
March 18-22, 2011
San Francisco, United States

Microbiota and Mucosal Immunology: The Interface in Health and Disease
April 14-16, 2011
San Francisco, United States

GTCbio 2nd International Conference on Cancer Immunotherapy & Immunomonitoring
May 2-5, 2011
Budapest, Hungary

NEW  World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-22, 2011
Seattle, United States

Gordon Research Conference: Viruses & Cells
May 29-June 3, 2011
Lucca (Barga), Italy

DNA Vaccines 2011
July 12-14, 2011
San Diego, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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