Volume 2.45 | Nov 26

Immune Regulation News 2.45, November 26, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Deciphering How CD4 T Cells Die During HIV Infection  ShareThis
Scientists have solved a long-standing mystery about HIV infection – namely how HIV promotes the death of CD4 T cells. [Press release from The Gladstone Institutes discussing online prepublication in Cell]

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SCIENCE NEWS

How Cannabis Suppresses Immune Functions: Cannabis Compounds Found to Trigger Unique Immune Cells Which Promote Cancer Growth
An international team of immunologists studying the effects of cannabis have discovered how smoking marijuana can trigger a suppression of the body’s immune functions. The research reveals why cannabis users are more susceptible to certain types of cancers and infections. [Press release from ScienceDaily discussing online prepublication in the European Journal of Immunology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue
In ex vivo cultures of human tonsil tissue, CD4 T cells undergo a pronounced cytopathic response following HIV infection. Strikingly, >95% of these dying cells are not productively infected but instead correspond to bystander cells. Researchers now show that the death of these “bystander” cells involves abortive HIV infection. [Cell]

Mzb1 Protein Regulates Calcium Homeostasis, Antibody Secretion, and Integrin Activation in Innate-Like B Cells
Marginal zone (MZ) B cells of the spleen and B1 cells, termed innate-like B cells, differ from follicular B cells by their attenuated Ca2+ mobilization, fast antibody secretion, and increased cell adhesion. Researchers identified and characterized Mzb1 as an endoplasmic reticulum-localized and B cell-specific protein that was most abundantly expressed in MZ B and B1 cells. [Immunity]

Endogenous Cortisol and TGF-Beta in Human Aqueous Humor Contribute to Ocular Immune Privilege by Regulating Dendritic Cell Function
Aqueous humor (AqH) has been shown to have significant immunosuppressive effects on APCs in animal models. Researchers wanted to establish whether, in humans, AqH can regulate dendritic cell function and to identify the dominant mechanism involved. [J Immunol]

Distinct Roles for the NK Cell-Activating Receptors in Mediating Interactions with Dendritic Cells and Tumor Cells
This study investigates the interaction of NK cells with dendritic cells and tumor cells, and the role of specific NK cell-activating receptors in this process. [J Immunol]

Cannabinoid Receptor Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Potent Immunosuppressive Properties
Here, researchers show that administration of delta9-tetrahydrocannabinol in mice leads to rapid and massive expansion of CD11b(+)Gr-1(+) myeloid-derived suppressor cells expressing functional arginase and exhibiting potent immunosuppressive properties both in vitro and in vivo. [Eur J Immunol]

Regulatory T Cells Predict the Time to Initial Treatment in Early Stage Chronic Lymphocytic Leukemia
Higher regulatory T cell levels had significant and independent prognostic power for predicting the time to initial treatment in patients with low to intermediate stage chronic lymphocytic leukemia. [Cancer]

Overrepresentation of IL-17A and IL-22 Producing CD8 T Cells in Lesional Skin Suggests Their Involvement in the Pathogenesis of Psoriasis
By spectral imaging analysis of double-stained skin sections researchers demonstrated that IL-17 was mainly expressed by mast cells and neutrophils and IL-22 by macrophages and dendritic cells. [PLoS ONE]

The Canonical BMP Signaling Pathway is Involved in Human Monocyte-Derived Dendritic Cell Maturation
In this study, researchers investigate the effects of bone morphogenetic protein signaling activation on the capacity of human dendritic cells to stimulate immune responses. [Immunol Cell Biol]


INDUSTRY NEWS

ImmunGene Receives $244,479 Grant Under The Patient Protection And Affordable Care Program For Its Anti-Cancer Technology
ImmunGene, Inc., a privately held drug development company focused on targeted antibody therapeutics with numerous anti-cancer functions built into a single therapy, announced that it has received a $244,479 grant under The Patient Protection and Affordable Care Act of 2010 (PPACA). [Biocompare]


POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


EVENTS (Listed by Date)

American Association for Cancer Research (AACR) Tumor Immunology – Basic and Clinical Advances
November 30-December 3, 2010
Miami, United States

Vaccines Europe 2010
December 1-2, 2010
London, United Kingdom

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

Safety Symposium organized by the NIH RAC and Co-hosted by CliniGene: Retroviral and Lentiviral Vectors for Long-Term Gene Correction: Clinical Challenges in Vector and Trial Design
December 9-10, 2010
Bethesda, United States

The 50th Midwinter Conference of Immunologists at Asilomar
January 22-25, 2011
Pacific Grove, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Phacilitate 9th Annual North American Vaccine Forum
January 24-26, 2011
Washington, D.C., United States

AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer
January 30-February 2, 2011
San Diego, United States

Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity
February 12-17, 2011
Santa Fe, United States

Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
February 15-20, 2011
Taos, United States

Lorne Infection and Immunity Conference 2011
February 16-18, 2011
Lorne, Australia

18th Conference on Retroviruses and Opportunistic Infections (CROI 2011)
February 27-March 2, 2011
Boston, United States

The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting
March 18-22, 2011
San Francisco, United States

Microbiota and Mucosal Immunology: The Interface in Health and Disease
April 14-16, 2011
San Francisco, United States

GTCbio 2nd International Conference on Cancer Immunotherapy & Immunomonitoring
May 2-5, 2011
Budapest, Hungary

American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-22, 2011
Seattle, United States

Gordon Research Conference: Viruses & Cells
May 29-June 3, 2011
Lucca (Barga), Italy

DNA Vaccines 2011
July 12-14, 2011
San Diego, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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