Volume 2.43 | Nov 12

Immune Regulation News 2.43, November 12, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

New Class of ‘Dancing’ Dendritic Cells Derived from Blood Monocytes  ShareThis
Dendritic cells are still notoriously difficult to study in humans. Samples, which come primarily from bone marrow or lymphoid tissue, are simply too difficult to obtain. But new research has shown scientists a way to study “authentic” dendritic cells from mouse monocytes, which are abundant in the blood, a much more accessible source in humans. [Press release from The Rockefeller University discussing online prepublication in Cell]

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SCIENCE NEWS

Epratuzumab Reduced Disease Activity in Adult Patients with Moderate to Severe Active Systemic Lupus Erythematosus (SLE)
UCB and U.S. based partner Immunomedics Inc. announced that results from the phase IIB study, EMBLEM(TM), showed that certain doses of epratuzumab were associated with a meaningful and statistically significant reduction in disease activity in adult patients with moderate to severe active SLE. [Press release from UCB discussing data presented at the 74th Annual Scientific Meeting of the American College of Rheumatology in Atlanta]

Discovery of an Anti-Inflammatory Substance
Biochemists at Kiel University, along with international scientists, have identified an important messenger in the immune system. [Press release from Kiel University discussing online prepublication in Nature Immunology]

Joint Pain Linked to Breast Cancer Drug Not Inflammatory Arthritis or Autoimmune Disease
A new study suggests joint complaints attributed to aromatase inhibitors, popular breast cancer drugs, are not associated with inflammatory arthritis or autoimmune disease. [Press release from Georgetown University Medical Center discussing data presented at the 74th Annual Scientific Meeting of the American College of Rheumatology in Atlanta]

Tiny Variants in a Protein that Alerts the Immune System to the Presence of Infection May Underlie the Rare Ability of Some Individuals to Control HIV Infection Without the Need for Medications
An international research team found that differences in five amino acids in HLA-B are associated with whether or not HIV-infected individuals can control viral levels with their immune system only. [Press release from Massachusetts General Hospital discussing online prepublication in Science]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
Dendritic cells (DCs), critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop into cells with critical features of DCs in vivo . Researchers now show that fully differentiated monocyte-derived DCs develop in mice and DC-SIGN/CD209a marks the cells. [Cell]

The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation
To define host genetic effects on the outcome of a chronic viral infection, researchers performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and analyzed the effects of individual amino acids within the classical HLA proteins. [Science]

A Role for IL-27p28 as an Antagonist of gp130-Mediated Signaling
Here, researchers show that IL-27 subunits p28 (IL-27p28), independently of EBI3, antagonized cytokine signaling through gp130 and IL-6-mediated production of IL-17 and IL-10. [Nat Immunol]

Immunosuppressive CD14(+)HLA-DR(low/neg) Monocytes in B Cell Non-Hodgkin’s Lymphoma
Researchers examined the immunophenotype of 40 non-Hodgkin’s lymphoma patients and 27 age-matched controls to better understand systemic immune suppression. [Blood]

Ubiquitination Regulates MHC Class II-Peptide Complex Retention and Degradation in Dendritic Cells
Researchers now show that ubiquitination of MHC class II-peptide complex (pMHC-II) by the E3 ubiquitin ligase membrane-associated RING-CH 1 regulates surface expression, intracellular distribution, and survival of pMHC-II in dendritic cells. [Proc Natl Acad Sci USA]

Role of Antigen Persistence and Dose for CD4+ T Cell Exhaustion and Recovery
Here, researchers dissected the behavior of primed CD4+ T cells exposed to persistent antigen using an inducible transgenic mouse system that allowed them to control antigen presentation as the only experimental variable, independent of the persistent inflammation and disease progression that complicate infectious models. [Proc Natl Acad Sci USA]

Increased B7-H1 Expression on Dendritic Cells Correlates with Programmed Death 1 Expression on T Cells in Simian Immunodeficiency Virus-Infected Macaques and May Contribute to T Cell Dysfunction and Disease Progression
Using the rhesus macaque model, researchers show B7-H1 (programmed death [PD]-L1) is expressed on lymphoid and mucosal dendritic cells (DCs) (both myeloid DCs and plasmacytoid DCs), and its expression significantly increases after simian immunodeficiency virus infection. [J Immunol]

Mesenchymal Stem Cells Contribute to the Abnormal Bone Marrow Microenvironment in Patients with Chronic Idiopathic Neutropenia by Overproduction of Transforming Growth Factor-Beta1
In this study, researchers investigated the possible involvement of bone marrow (BM) mesenchymal stem cells (MSCs) in the pathophysiology of chronic idiopathic neutropenia by assessing the frequency and function of BM MSCs in terms of the proliferative/clonogenic characteristics, the differentiation capacity, the potential to produce pro-inflammatory cytokines and the ability to suppress T cell proliferation. [Stem Cells Dev]

Indoleamine 2,3-Dioxygenase and Regulatory Dendritic Cells Contribute to the Allograft Protection Induced by Infusion of Donor-Specific Splenic Stromal Cells
Here, researchers have used both murine skin and cardiac allograft transplantation models to explore whether in vivo alloresponses can be regulated by infusion with donor-derived splenic stromal cells (SSCs) and to investigate the possible mechanisms by which SSCs exert regulatory effects to prevent allograft rejection. [Cell Mol Immunol]


INDUSTRY NEWS

Apricus Bio Awarded Three Qualifying Therapeutic Discovery Project Grants
Apricus Biosciences, Inc., announced the award of three grants totaling $733,437 under the Qualifying Therapeutic Discovery Project program for PrevOnco(TM), RayVa(TM) and Femprox(R) which are the Company’s development programs in cancer, autoimmune/cardiovascular and female sexual dysfunction, respectively. [Apricus Biosciences, Inc. Press Release]

Resolve Licenses Potential Autoimmune Disease Treatments from University of Washington
Resolve Therapeutics, LLC announced that it has entered into an exclusive license with the University of Washington for certain biologic compounds and technology developed to treat autoimmune diseases including systemic lupus erythematosus. [PR Newswire]

Celtaxsys Looks to Raise $10 Million
Atlanta-based Celtaxsys is seeking more than $10 million to develop drugs that can control the movement of immune cells. [FierceBiotech]


POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


EVENTS (Listed by Date)

39th Autumn Immunology Conference
November 19-22, 2010
Chicago, United States

American Association for Cancer Research (AACR) Tumor Immunology – Basic and Clinical Advances
November 30-December 3, 2010
Miami, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

The 50th Midwinter Conference of Immunologists at Asilomar
January 22-25, 2011
Pacific Grove, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Phacilitate 9th Annual North American Vaccine Forum
January 24-26, 2011
Washington, D.C., United States

AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer
January 30-February 2, 2011
San Diego, United States

Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity
February 12-17, 2011
Santa Fe, United States

Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
February 15-20, 2011
Taos, United States

Lorne Infection and Immunity Conference 2011
February 16-18, 2011
Lorne, Australia

18th Conference on Retroviruses and Opportunistic Infections (CROI 2011)
February 27-March 2, 2011
Boston, United States

The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting
March 18-22, 2011
San Francisco, United States

Microbiota and Mucosal Immunology: The Interface in Health and Disease
April 14-16, 2011
San Francisco, United States

GTCbio 2nd International Conference on Cancer Immunotherapy & Immunomonitoring
May 2-5, 2011
Budapest, Hungary

American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-21, 2011
Seattle, United States

Gordon Research Conference: Viruses & Cells
May 29-June 3, 2011
Lucca (Barga), Italy

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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