Volume 2.42 | Nov 5

Immune Regulation News 2.42, November 5, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Certain Cancer Therapies’ Success Depends on Presence of Immune Cell, Study Shows In Mice  ShareThis
Researchers found that disabling the Myc oncogene in mice with Myc -dependent leukemias caused complete regression of tumors only in mice with intact immune systems. [Press release from the Stanford University School of Medicine discussing online prepublication in Cancer Cell]

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SCIENCE NEWS

Penn Study Shows Two-Sided Immune Cell Could be Harnessed to Shrink Tumors
Researchers have discovered how a stimulatory molecule and a protein found on the membrane of another immune cell make T helper 17 cells multi-taskers of sorts. [Press release from the University of Pennsylvania School of Medicine discussing online prepublication in Science Translational Medicine]

Macrophage Protein Has Major Role in Inflammation
Researchers have discovered that a multi-tasking protein FoxO1 has another important but previously unknown function: It directly interacts with macrophages, promoting an inflammatory response that can lead to insulin resistance and diabetes. [Press release from the University of California, San Diego discussing online prepublication in The EMBO Journal]

NIH Scientists Discover Secrets of Helper T Cells Involved in Autoimmunity
Scientists have redefined the roles of several cytokines involved in the generation of immune cells implicated in severe autoimmune diseases. The study in mice showed that development of T helper 17 (Th17) immune cells can occur without the presence of transforming growth factor-beta, a mediator thought to be required for Th17 cell development. [Press release from the National Institutes of Health discussing online prepublication in Nature]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Generation of Pathogenic TH17 Cells in the Absence of TGF-Beta Signaling
Here, researchers show that CD4+ T helper 17 cell (Th17) differentiation can occur in the absence of TGF-beta signaling. [Nature]

Plasma Cells Negatively Regulate the Follicular Helper T Cell Program
B lymphocytes differentiate into antibody-secreting cells under the antigen-specific control of follicular helper T cells. Here, researchers demonstrate that isotype-switched plasma cells expressed major histocompatibility complex class II, the costimulatory molecules CD80 and CD86, and the intracellular machinery required for antigen presentation. [Nat Immunol]

A Genetically Selective Inhibitor Demonstrates a Function for the Kinase Zap70 in Regulatory T Cells Independent of its Catalytic Activity
Researchers found that conventional naive, effector and memory T cells were dependent on the kinase activity of Zap70 for their activation, which demonstrated a nonredundant role for Zap70 in signals induced by the T cell antigen receptor. [Nat Immunol]

CD1a-Autoreactive T Cells are a Normal Component of the Human AlphaBeta T Cell Repertoire
Using an experimental system that bypasses major histocompatibility complex restriction and the requirement for defined antigens, researchers show that polyclonal T cells responded at higher rates to cells expressing CD1a than to those expressing CD1b, CD1c or CD1d. [Nat Immunol]

CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation
Here, researchers show that an intact immune system, specifically CD4+ T cells, is required for the induction of cellular senescence, shutdown of angiogenesis, and chemokine expression resulting in sustained tumor regression upon inactivation of the MYC or BCR-ABL oncogenes in mouse models of T cell acute lymphoblastic lymphoma and pro-B cell leukemia, respectively. [Cancer Cell]

Regulation of Cytokine Secretion in Human CD127+ LTi-Like Innate Lymphoid Cells by Toll-Like Receptor 2
The results indicate that human LTi-like innate lymphoid cells (ILC) can directly sense bacterial components and unravel a previously unrecognized functional heterogeneity among this important population of ILC. [Immunity]

Regulation of Steady-State Neutrophil Homeostasis by Macrophages
By conditionally deleting the anti-apoptotic gene cellular FLICE-like inhibitory protein (c-FLIP) in myeloid cells, researchers have generated a novel mouse model deficient in marginal zone and bone marrow stromal macrophages. [Blood]

Slc15a4, AP-3, and Hermansky-Pudlak Syndrome Proteins are Required for Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells
Researchers designed a genetic screen to identify proteins required for the development and specialized function of plasmacytoid dendritic cells. [Proc Natl Acad Sci USA]

Aryl Hydrocarbon Receptor Negatively Regulates Dendritic Cell Immunogenicity via a Kynurenine-Dependent Mechanism
Here, researchers show that lipopolysaccharide and CpG stimulate aryl hydrocarbon receptor (Ahr) expression in bone marrow-derived dendritic cells. Furthermore, they found that Ahr is required to induce indoleamine 2,3-dioxygenase expression, an immunosuppressive enzyme that catabolizes tryptophan into kynurenine and other metabolites in dendritic cells. [Proc Natl Acad Sci USA]

Umbilical Cord-Derived Mesenchymal Stromal Cells Modulate Monocyte Function to Suppress T Cell Proliferation
In this paper, researchers report that suppression of mitogen-induced T cell proliferation by human umbilical cord-, bone marrow-, and cord blood-mesenchymal stromal cells required monocytes. [J Immunol]

The Inducible Costimulator (ICOS) Is Critical for the Development of Human Th17 Cells
The findings reveal a vital role for ICOS signaling in the generation and maintenance of human Th17 cells and suggest that components of this pathway could be therapeutically targeted to treat cancer or chronic infection and, conversely, that interruption of this pathway may have utility in multiple sclerosis and other autoimmune syndromes. [Sci Transl Med]


INDUSTRY NEWS

ChemoCentryx Reports One-Year Results from PROTECT-1 Study Demonstrating Traficet-EN’s Effectiveness in Treating Patients with Crohn’s Disease at the United European Gastroenterology Federation (UEGW) Meeting
ChemoCentryx, Inc., announced that it reported one-year results from the Company’s PROTECT-1 Study (the Prospective Randomized Oral Therapy Evaluation in Crohn’s disease Trial) of Traficet-EN™ (CCX282-B) in patients with moderate-to-severe Crohn’s disease. [ChemoCentryx, Inc. Press Release]

Pharmasan Labs, Inc. Wins Grant for Novel Immune Tolerance Test (ITT)-Cytokine Platform
Pharmasan Labs, Inc. and NeuroScience, Inc. announce that Pharmasan Labs is the recipient of a $244,479 grant under the highly competitive Qualifying Therapeutic Discovery Project (QDTP) Program established by the Patient Protection and Affordable Care Act of 2010. [NeuroScience, Inc. Press Release]

Aduro BioTech Awarded $442,000 Under U.S. Qualified Therapeutic Discovery Project Program
Aduro BioTech announced that it has been awarded two cash grants totaling approximately $442,000 under the U.S. Government’s Qualifying Therapeutic Discovery Project (QTDP) program. [BusinessWire]

Karyopharm Lands $20 Million in Series A
Karyopharm Therapeutics has completed a $20 million Series A round of financing with the help of unidentified backers, according to a company press release. [FierceBiotech]


POLICY NEWS

NIH Introduces Images, a Database of Images in Biomedical Literature
More than 2.5 million images and figures from medical and life sciences journals are now available through Images, a new resource for finding images in biomedical literature. [National Institutes of Health, United States]

NIH Recovery Act Grants to Foster Scientific Workforce Diversity
The National Institutes of Health has awarded six grants totaling approximately $12 million over three years through a new initiative aimed at fostering a diverse scientific workforce. [National Institutes of Health, United States]

Guidelines for Use of Stored Specimens and Access to Ancillary Data and Proposed Cost Schedule: Stored Biologic Specimens and Ancillary Data From the Collaborative Perinatal Project (CPP) (FR Doc. 2010-27183) [National Institutes of Health, United States]

National Heart, Lung, and Blood Institute; Notice of Closed Meetings (FR Doc. 2010-27319) [National Institutes of Health, United States]

National Heart, Lung, and Blood Institute; Notice of Meetings (FR Doc. 2010-27318) [National Institutes of Health, United States]

National Heart, Lung, and Blood Institute; Notice of Closed Meeting (FR Doc. 2010-26889) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27325) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27185) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27192) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27039) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27040) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27049) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26881) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-26935) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-27410) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-27187) [National Institutes of Health, United States]


EVENTS (Listed by Date)

The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology
November 6-9, 2010
Singapore

GTCbio 8th Annual Vaccines: “All Things Considered” Conference
November 8-9, 2010
Washington, D.C., United States

2010 Annual Meeting of the American College of Allergy, Asthma & Immunology
November 11-16, 2010
Phoenix, United States

Understanding Dendritic Cells and Their Ability to Regulate Immune Responses
November 12, 2010
Hertfordshire, United Kingdom

39th Autumn Immunology Conference
November 19-22, 2010
Chicago, United States

American Association for Cancer Research (AACR) Tumor Immunology – Basic and Clinical Advances
November 30-December 3, 2010
Miami, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

The 50th Midwinter Conference of Immunologists at Asilomar
January 22-25, 2011
Pacific Grove, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Phacilitate 9th Annual North American Vaccine Forum
January 24-26, 2011
Washington, D.C., United States

AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer
January 30-February 2, 2011
San Diego, United States

Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity
February 12-17, 2011
Santa Fe, United States

Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
February 15-20, 2011
Taos, United States

Lorne Infection and Immunity Conference 2011
February 16-18, 2011
Lorne, Australia

18th Conference on Retroviruses and Opportunistic Infections (CROI 2011)
February 27-March 2, 2011
Boston, United States

The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting
March 18-22, 2011
San Francisco, United States

Microbiota and Mucosal Immunology: The Interface in Health and Disease
April 14-16, 2011
San Francisco, United States

GTCbio 2nd International Conference on Cancer Immunotherapy & Immunomonitoring
May 2-5, 2011
Budapest, Hungary

American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-21, 2011
Seattle, United States

Gordon Research Conference: Viruses & Cells
May 29-June 3, 2011
Lucca (Barga), Italy

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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