Volume 2.41 | Oct 29

Immune Regulation News 2.41, October 29, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Ig Gene-Like Molecule CD31 Plays a Nonredundant Role in the Regulation of T Cell Immunity and Tolerance  ShareThis
Researchers conclude that CD31 functions as a nonredundant comodulator of T cell responses, which specializes in sizing the ensuing immune response by setting the threshold for T cell activation and tolerance, while preventing memory T cell death. [Proc Natl Acad Sci USA]

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SCIENCE NEWS

Mount Sinai Researchers Make Groundbreaking Discovery on Origin of Brain’s Immune Cells
Researchers have discovered that microglia have a unique origin and are formed shortly after conception. [Press release from the Mount Sinai Medical Center discussing online prepublication in Science]

Cancer’s Hiding Spots Revealed
In a study of mice with lymphoma, MIT biologists have discovered that a small number of cancer cells escape chemotherapy by hiding out in the thymus. [Press release from Massachusetts Institute of Technology discussing online prepublication in Cell]

Haptoglobin as an Early Serum Biomarker of Virus-Induced Type I Diabetes In Rats
Researchers have utilized several well-established rat models of virus-induced type I diabetes to search for serum biomarkers that occur early in disease development. [Press release from Biocompare discussing online prepublication in Experimental Biology and Medicine]

Immune Cells Deploy Traps to Catch and Kill Pathogens
A new study reveals that two enzymes help immune cells deploy pathogen-killing traps by unraveling and using the chromatin (DNA and its associated proteins) contained in the cells’ nuclei to form defensive webs. [Press release from EurekAlert! discussing online prepublication in The Journal of Cell Biology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DNA Damage-Mediated Induction of a Chemoresistant Niche
Here, researchers use a well-established mouse model of Burkitt’s lymphoma to show that paracrine factors in the tumor microenvironment modulate lymphoma cell survival following the administration of genotoxic chemotherapy. [Cell]

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Researchers show that postnatal hematopoietic progenitors do not significantly contribute to microglia homeostasis in the adult brain. [Science]

Critical Role for the Chemokine Receptor CXCR6 in NK Cell-Mediated Antigen-Specific Memory of Haptens and Viruses
Researchers report that hepatic natural killer (NK) cells, but not splenic or naïve NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus or human immunodeficiency virus type 1. [Nat Immunol]

Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 (CEACAM1) Regulates Granulopoiesis by Inhibition of Granulocyte Colony-Stimulating Factor Receptor
CEACAM1 expression correlated with granulocytic differentiation, and Ceacam1-/- mice developed neutrophilia because of loss of the Src-homology-phosphatase-1 (SHP-1)-dependent inhibition of granulocyte colony-stimulating factor receptor (G-CSFR) signal transducer and activator of transcription (Stat3) pathway provided by CEACAM1. [Immunity]

Immune Modulation by Fas Ligand Reverse Signaling: Lymphocyte Proliferation is Attenuated by the Intracellular Fas Ligand Domain
The results demonstrate that Fas ligand intracellular domain signaling impairs activation-induced proliferation in B and T cells by diminishing phosphorylation of PLCgamma, PKC and ERK1/2. [Blood]

Human Effector CD8+ T Cells Derived from Naïve Rather than Memory Subsets Possess Superior Traits for Adoptive Immunotherapy
Researchers investigated human CD8+ T cells and found that naïve cells were not only the most abundant subset, but also the most capable of in vitro expansion and of T cell receptor transgene expression. [Blood]

Vasoactive Intestinal Peptide Loss Leads to Impaired CNS Parenchymal T Cell Infiltration and Resistance to Experimental Autoimmune Encephalomyelitis
The results indicate that vasoactive intestinal peptide plays an unanticipated permissive and/or proinflammatory role in the propagation of the inflammatory response in the CNS, a finding with potential therapeutic relevance in autoimmune neuroinflammatory diseases such as multiple sclerosis. [Proc Natl Acad Sci USA]

Convergent Recombination Shapes the Clonotypic Landscape of the Naïve T Cell Repertoire
Here, researchers tested the key predictions of convergent recombination in a comprehensive evaluation of the naïve CD8+ T cell receptor-beta repertoire in mice. [Proc Natl Acad Sci USA]

Cytokine-Dependent but Acquired Immunity-Independent Arthritis Caused by DNA Escaped from Degradation
Here, researchers showed that when bone marrow cells from the DNase II-deficient mice were transferred to the wild-type mice, they developed arthritis. [Proc Natl Acad Sci USA]

IFN-Gamma Abrogates Endotoxin Tolerance by Facilitating Toll-Like Receptor-Induced Chromatin Remodeling
The results identify a mechanism by which IFN-gamma promotes activation of macrophages and highlight the importance of chromatin remodeling and transcriptional control in the regulation of inflammatory cytokine production in tolerant and activated macrophages. [Proc Natl Acad Sci USA]

Umbilical Cord-Derived Mesenchymal Stromal Cells Modulate Monocyte Function to Suppress T Cell Proliferation
In this paper, researchers report that suppression of mitogen-induced T cell proliferation by human umbilical cord-, bone marrow-, and cord blood-mesenchymal stromal cells required monocytes. [J Immunol]

Haptoglobin as an Early Serum Biomarker of Virus-Induced Autoimmune Type I Diabetes in Biobreeding Diabetes Resistant and LEW1.WR1 Rats
In this study, researchers utilized two-dimensional gel analysis followed by matrix-assisted-laser desorption/ionization time-of-flight mass spectrometry analysis to identify putative serum biomarkers for autoimmune type I diabetes in biobreeding diabetes resistant rats induced to express the disease. [Exp Biol Med]


INDUSTRY NEWS

Is Our Too Clean Culture Making Our Kids Sick?
Rising levels of allergic asthma and eczema in North American children have Canadian scientists wondering if there is such a thing as being “too clean.” [Genome British Columbia Press Release]

GlobeImmune Expands GI-5005-02 Phase IIb Trial to Include Additional Treatment Naïve IL28B T/T Subjects with Chronic Genotype 1 HCV
GlobeImmune Inc. announced the expansion of its Phase IIb clinical trial of GI-5005, an investigational Tarmogen product for the treatment of hepatitis C virus infection. [GlobeImmune Inc. Press Release]

MacroGenics Enters Global Research Collaboration and License Agreement with Pfizer
MacroGenics, Inc, a leader in next-generation antibody platforms and therapeutics, announced that it has entered into a global research collaboration and license agreement with Pfizer Inc. to discover, develop and commercialize Dual-Affinity Re-Targeting (DART™) products directed at two undisclosed cancer targets. [MacroGenics, Inc. Press Release]

Immune Design Grants Adjuvant License to MedImmune
Immune Design Corp., a privately held biotechnology company developing novel vaccines and immunotherapies for infectious disease and cancer, announced that it has entered into a license and development agreement with MedImmune for the use and commercialization of IDC’s proprietary Glucopyranosyl Lipid Adjuvant (GLA) as a component in vaccines for select infectious diseases. [PR Newswire]


POLICY NEWS

NIH Recovery Act Awards Enable Crucial Health Research Technologies
Thanks to the Recovery Act, more health scientists now will have access to state-of-the-art devices, the National Institutes of Health announced. Through its National Center for Research Resources, NIH has awarded $300 million in shared instrumentation grants.  [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26362) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26363) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26317) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26497) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26499) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26028) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-26702) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-26706) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-26390) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-26036) [National Institutes of Health, United States]

Public Submissions: Proposed Standards and Code of GMP for Human Blood and Blood Components, Human Tissues and Human Cellular Therapies [Therapeutic Goods Administration, Australia]


EVENTS (Listed by Date)

The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology
November 6-9, 2010
Singapore

GTCbio 8th Annual Vaccines: “All Things Considered” Conference
November 8-9, 2010
Washington, D.C., United States

2010 Annual Meeting of the American College of Allergy, Asthma & Immunology
November 11-16, 2010
Phoenix, United States

Understanding Dendritic Cells and Their Ability to Regulate Immune Responses
November 12, 2010
Hertfordshire, United Kingdom

39th Autumn Immunology Conference
November 19-22, 2010
Chicago, United States

American Association for Cancer Research (AACR) Tumor Immunology – Basic and Clinical Advances
November 30-December 3, 2010
Miami, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

The 50th Midwinter Conference of Immunologists at Asilomar
January 22-25, 2011
Pacific Grove, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Phacilitate 9th Annual North American Vaccine Forum
January 24-26, 2011
Washington, D.C., United States

AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer
January 30-February 2, 2011
San Diego, United States

Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity
February 12-17, 2011
Santa Fe, United States

Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
February 15-20, 2011
Taos, United States

NEW Lorne Infection and Immunity Conference 2011
February 16-18, 2011
Lorne, Victoria

18th Conference on Retroviruses and Opportunistic Infections (CROI 2011)
February 27-March 2, 2011
Boston, United States

The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting
March 18-22, 2011
San Francisco, United States

Microbiota and Mucosal Immunology: The Interface in Health and Disease
April 14-16, 2011
San Francisco, United States

GTCbio 2nd International Conference on Cancer Immunotherapy & Immunomonitoring
May 2-5, 2011
Budapest, Hungary

American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-21, 2011
Seattle, United States

Gordon Research Conference: Viruses & Cells
May 29-June 3, 2011
Lucca (Barga), Italy

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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