Volume 2.39 | Oct 15

Immune Regulation News 2.39, October 15, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

A Crucial Link in Immune Development and Regulation Unearthed  ShareThis
An Australian team of scientists has uncovered a quality control mechanism that must take place for our immune system to subsequently effectively destroy harmful viruses and bacteria. [Press release from Monash University discussing online prepublication in Nature]

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SCIENCE NEWS

Cell Survival Protein Discovery Rewrites Immune System Story
A discovery is set to rewrite a long-held belief about how the body’s immune system establishes its memory. [Press release from the Walter and Eliza Hall Institute discussing online prepublication in Science]

Studying Illnesses Caused by Worms
Biomedical researchers are investigating illnesses caused by these gut-dwelling worms in an effort to decipher how immune cells send and receive signals that determine the specific immune response to mount. [Press release from the Trudeau Institute discussing online prepublication in the Journal of Immunology]

UT Southwestern Study to Determine Whether Leptin Helps Type I Diabetes Patients
A clinical trial aims to determine whether adding the hormone leptin to standard insulin therapy might help rein in the tumultuous blood-sugar levels of people with type I diabetes. [The University of Texas Southwestern Medical Center Press Release]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

The Structural Basis for Autonomous Dimerization of the Pre-T Cell Antigen Receptor
The pre-T-cell antigen receptor (pre-TCR) comprises an invariant alpha-chain (pre-Talpha) that pairs with any TCR beta-chain (TCRbeta) following successful TCR beta-gene rearrangement. The unusual dual-chaperone-like sensing function of pre-Talpha represents a unique mechanism in nature whereby developmental quality control regulates the expression and signalling of an integral membrane receptor complex. [ Nature]

Mcl-1 is Essential for Germinal Center Formation and B Cell Memory
Here, researchers investigated the consequences of deleting genes encoding the anti-apoptotic molecules Mcl1 and Bcl2l1 from B cells using an inducible system synchronized with expression of activation-induced cytidine deaminase following immunization. [Science]

Structures of the CXCR4 Chemokine G Protein-Coupled Receptor With Small-Molecule and Cyclic Peptide Antagonists
Here, researchers report five independent crystal structures of CXCR4 bound to an antagonist small molecule IT1t and a cyclic peptide CVX15 at 2.5 to 3.2 angstrom resolution. [Science]

IL-12 Initiates Tumor Rejection via Lymphoid Tissue-Inducer Cells Bearing the Natural Cytotoxicity Receptor NKp46
By systematic analysis of the IL-12-induced immune response to subcutaneous melanoma (B16), researchers found that tumor suppression was mediated independently of T lymphocytes or natural killer cells. [Nat Immunol]

IL-37 is a Fundamental Inhibitor of Innate Immunity
Expression of IL-37 in macrophages or epithelial cells almost completely suppressed production of pro-inflammatory cytokines, whereas the abundance of these cytokines increased with silencing of endogenous IL-37 in human blood cells. [Nat Immunol]

The microRNA miR-182 Is Induced by IL-2 and Promotes Clonal Expansion of Activated Helper T Lymphocytes
Here, researchers show that in the late phase of expansion, Foxo1 was no longer post-translationally regulated but was inhibited post-transcriptionally by the interleukin 2 (IL-2)-induced microRNA miR-182. [Nat Immunol]

Early B Cell Factor 2 Regulates Hematopoietic Stem Cell Homeostasis in a Cell-Nonautonomous Manner
Here, researchers examine the role of early B cell factor 2 (Ebf2), a transcription factor expressed in a subset of immature osteoblastic cells. Ebf2-/- mice show decreased frequencies of hematopoietic stem cells and lineage-committed progenitors. [Cell Stem Cell]

Intravital Imaging Reveals Distinct Dynamics for Natural Killer and CD8+ T Cells during Tumor Regression
To address how NKG2D engagement affects intratumoral natural killer cell dynamics, researchers performed intravital microscopy in a Rae-1beta-expressing solid tumor. [Immunity]

Early Lymphocyte Recovery Following Intensive Timed Sequential Chemotherapy for Acute Myelogenous Leukemia: Peripheral Oligoclonal Expansion of Regulatory T Cells
To test the hypothesis that lymphocyte recovery mirrors ontogeny, researchers characterized early lymphocyte recovery and attendant cytokine profiles in twenty consecutive patients undergoing induction timed sequential chemotherapy for newly diagnosed acute myelogenous leukemia. [Blood]

A Nonredundant Role for IL-21 Receptor Signaling in Plasma Cell Differentiation and Protective Type 2 Immunity Against Gastrointestinal Helminth Infection
In the present study, researchers identify IL-21R signaling as a critical factor in driving pathogen-specific plasma cell differentiation and protective immunity against H. polygyrus in mice. [J Immunol]


INDUSTRY NEWS

ImmunoCellular Therapeutics’ Clinical Data for ICT-107 Featured at World Stem Cell Summit
ImmunoCellular Therapeutics, a biotechnology company focused on the development of novel immune-based cancer therapies, announced that the company’s clinical data from ICT-107 will be featured in two oral sessions at the World Stem Cell Summit. [ImmunoCellular Therapeutics, Ltd. Press Release]

Micromet Announces FDA Acceptance of Investigational New Drug Application for BiTE Antibody MT111/MEDI-565
Micromet, Inc. announced that its licensee for MT111, MedImmune, plans to initiate a Phase I trial in patients with advanced gastrointestinal cancers based on an investigational new drug application recently accepted by the U.S. Food and Drug Administration (FDA). MT111, also known as MEDI-565, is a BiTE(R) antibody designed to direct a patient’s T cells against cancer cells that express carcinoembryonic antigen. [Micromet, Inc. Press Release]

U.S. Food and Drug Administration Approves Aridol
Pharmaceutical company Pharmaxis is pleased to announce the U.S. Food and Drug Administration has approved Aridol™ (mannitol inhalation powder) Bronchial Challenge Test Kit for marketing. [Pharmaxis Ltd. Press Release]

STEMSOFT Connect – A Simplified Solution to a Complex Problem
STEMSOFT is pleased to announce the release of their new standard interfaces, STEMSOFT Connect™.  STEMSOFT Connect offers standard interface tools that easily connect commonly used applications and devices to STEMSOFT’s applications. [STEMSOFT Software Inc. Press Release]


POLICY NEWS

NIH Funds Advanced Development of Three Biodefense Vaccines
The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, announced three new contracts to fund research on vaccines to protect against emerging infectious diseases and biological threats that could be used in a terror attack. [National Institutes of Health, United States]

NIH Announces New Program to Accelerate Research Independence
The National Institutes of Health intends to invest approximately $60 million over the next five years in the NIH Director’s Early Independence Award program to help junior investigators leapfrog over traditional post-doctoral training and move into independent academic positions at U.S. institutions, directly upon completion of their graduate research degrees. [National Institutes of Health, United States]

NIH Launches Genotype-Tissue Expression Project
The National Institutes of Health (NIH) announced awards to support an initiative to understand how genetic variation may control gene activity and its relationship to disease. Launched as a pilot phase, the Genotype-Tissue Expression (GTEx) project will create a resource researchers can use to study inherited susceptibility to illness and will establish a tissue bank for future biological studies. [National Institutes of Health, United States]

FDA’s $25 Million Pitch for Improving Drug Regulation
The U.S. Food and Drug Administration (FDA) is pressing for a big funding boost for “regulatory science”- research that can help it evaluate new treatments better and faster. [Food and Drug Administration, United States]

FDA to Push for More Investment in Science
Health regulators plan to spend millions of dollars to step up their scientific prowess in a move that officials say will help quickly get new treatments to patients and protect the public against possible health threats. [Food and Drug Administration, United States]

FDA Issues Regulatory Science Report
The U.S. Food and Drug Administration unveiled a report outlining the agency’s plans to advance regulatory science through its Regulatory Science Initiative. [Food and Drug Administration, United States]

Plan to Develop a Genetic Testing Registry at the National Institutes of Health; Public Meeting; Request for Comments (FR Doc. 2010-25411) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25171) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25180) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25185) [National Institutes of Health, United States]


EVENTS (Listed by Date)

The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology
November 7-10, 2010
Singapore

2010 Annual Meeting of the American College of Allergy, Asthma & Immunology
November 11-16, 2010
Phoenix, United States

39th Autumn Immunology Conference
November 19-22, 2010
Chicago, United States

NEW Tumor Immunology: Basic and Clinical Advances
November 30-December 3, 2010
Miami, United Sates

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

NEW  5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

The 50th Midwinter Conference of Immunologists at Asilomar
January 22-25, 2011
Pacific Grove, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

Phacilitate 9th Annual North American Vaccine Forum
January 24-26, 2011
Washington, DC, United States

NEW  AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer
January 30-February 2, 2011
San Diego, United Sates

Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity joint with Cancer Control by Tumor Suppressors and Immune Effectors
February 12-17, 2011
Santa Fe, United States

Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
February 15-20, 2011
Taos, United States

BMT Tandem Meetings (ASBMT/CIBMTR)
February 17-21, 2011
Honolulu, Hawaii

18th Conference on Retroviruses and Opportunistic Infections (CROI 2011)
February 27-March 2, 2011
Boston, United States

The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting
March 18-22, 2011
San Francisco, United States

Microbiota and Mucosal Immunology: The Interface in Health and Disease
April 14-16, 2011
San Francisco, United States

GTCbio: 2nd International Conference on Cancer Immunotherapy & Immunomonitoring
May 2-5, 2011
Budapest, Hungary

American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-22, 2011
Seattle, United States

Gordon Research Conference: Viruses & Cells
May 29-June 3, 2011
Lucca (Barga), Italy

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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