Volume 2.38 | Oct 8

Immune Regulation News 2.38, October 8, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Mice With Human Body’s Defences  ShareThis
Therapeutic antibodies can be an efficient alternative when common drugs do not work anymore.  However, antibodies obtained from blood of animals such as mice could not be used because the human immune system recognizes them as foreign and rejects them. With the help of human stem cells, researchers generated mice with a human immune system, which were then vaccinated to produce human monoclonal antibodies. [Press release from the Helmholtz Centre for Infection Research discussing online prepublication in PLoS ONE]

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SCIENCE NEWS

OHSU Primate Center Research Reveals Possible Method for Boosting the Immune System To Protect Infants Against HIV
Researchers at Oregon Health & Science University may have uncovered a new weapon for combating HIV as it is passed from mother to newborn child. [Press release from the Oregon Health & Science University discussing online prepublication in Nature Medicine]

Vaccine Extends Glioblastoma Patients’ Survival in Phase II Trial
A vaccine that turns the immune system against brain tumor cells bearing a genetic mutation that drives the most aggressive form of glioblastoma multiforme improved survival of patients in a phase II clinical trial, researchers reported. [Press release from the MD Anderson Cancer Center discussing online prepublication in the Journal of Clinical Oncology]

T Cell Discovery Shows Promise for Type I Diabetes Treatment: UBC-CFRI Study
A research team has identified the role of a type of T cell in type I diabetes that may lead to new treatment options for young patients. [Press release from the University of British Columbia discussing online prepublication in the Journal of Immunology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Passive Neutralizing Antibody Controls SHIV Viremia and Enhances B Cell Responses in Infant Macaques
The studies support the use of neutralizing antibodies in enhancing B cell responses and viral control in perinatal settings. [Nat Med]

Invariant NKT Cells Modulate the Suppressive Activity of IL-10-Secreting Neutrophils Differentiated with Serum Amyloid A
Neutrophils are the main effector cells during inflammation, but they can also control excessive inflammatory responses by secreting anti-inflammatory cytokines. However, the mechanisms that modulate their plasticity remain unclear. Researchers now show that systemic serum amyloid A 1 controls the plasticity of neutrophil differentiation. [Nat Immunol]

Mammalian Target of Rapamycin Controls Dendritic Cell Development Downstream of Flt3 Ligand Signaling
Researchers report that mammalian target of rapamycin (mTOR) inhibitor rapamycin impaired Flt3L-driven dendritic cell (DC) development in vitro, with the plasmacytoid DCs and CD8+-like classical DCs most profoundly affected. [Immunity]

Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma
Epidermal growth factor receptor variant III-targeted vaccination in patients with glioblastoma multiforme warrants investigation in a phase III, randomized trial. [J Clin Oncol]

Stimulation and Inhibition of FVIII-Specific Memory-B Cell Responses by CpG-B (ODN 1826), A Ligand for Toll-Like Receptor 9
Researchers asked how stimulation and inhibition of Factor VIII (FVIII)-specific memory B cells by low and high concentrations of FVIII, respectively, are affected by concurrent activation of the innate immune system. [Blood]

Interferon Gamma Limits the Effectiveness of Melanoma Peptide Vaccines
The results demonstrate that peptide vaccines can eradicate large established tumors in circumstances where the inhibitory activities of interferon gamma are curtailed. [Blood]

Relevance of the Mevalonate Biosynthetic Pathway in the Regulation of Bone Marrow Mesenchymal Stromal Cell-Mediated Effects on T Cell Proliferation and B Cell Survival
Herein, researchers defined the effects of cholesterol synthesis inhibitors on the interaction between these mesenchymal stromal cells and T or B lymphocytes. [Haematologica]

Inhibition of Immune Synapse by Altered Dendritic Cell Actin Distribution: A New Pathway of Mesenchymal Stem Cell Immune Regulation
The aim of this work was to elucidate the immunogenic effects of bone marrow mesenchymal stem cell/dendritic cell (DC) interactions during DC activation (LPS stimulation or Ag loading). [J Immunol]

Cellular Requirements for Diabetes Induction in DO11.10xRIPmOVA Mice
The results help define the events leading to diabetes in DO11.10xRIPmOVA mice and provide new insights into the cellular interactions required for disease development in an antigen-specific model of type I diabetes. [ J Immunol]

Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice
In this work, researchers describe a novel approach to generate fully human monoclonal antibodies by combining a humanized mouse model with a new B cell immortalization technique. [PLoS ONE]

INDUSTRY NEWS

Juvaris BioTherapeutics Announces Publication of Preclinical Anti-Leukemic Effects of JVRS-100 Immunotherapy
Juvaris BioTherapeutics, Inc. announced that results from preclinical studies using its lead compound, JVRS-100, as an immunotherapy to treat acute myelogenous leukemia were published. [Juvaris BioTherapeutics, Inc. Press Release]

Immunovaccine and IRX Therapeutics Collaborate on Cancer Immunotherapies
Immunovaccine Inc. and IRX Therapeutics, announced that the two companies have entered into a preclinical research collaboration to evaluate the combination of IRX’s primary cell-derived biologic, IRX-2, and DepoVax(TM)- based therapeutic cancer vaccines. [Immunovaccine Inc. Press Release]



POLICY NEWS

NIH Grants Will Advance Studies of the Form and Function of Proteins
The National Institutes of Health has awarded 23 grants for structural biology research totaling up to $290 million over five years. [National Institutes of Health, United States]

NCBI Launches the Database of Genomic Structural Variations
The National Institutes of Health announced the launch of a new resource, called the Database of Genomic Structural Variation, or dbVar, to help scientists understand how differences in DNA contribute to human health and disease. [National Institutes of Health, United States]

Lawmakers Introduce Bipartisan Legislation to Create Jobs and Promote Investment in Life Sciences
U.S. Representatives introduced bipartisan legislation that will provide tax incentives for small and mid-sized businesses to invest in life sciences research and development on a targeted basis. The Life Sciences Jobs and Investment Act of 2010 provides an opportunity to enhance medical innovation, life sciences education and job creation in the United States. [House of Representatives, United States]

NIH and FDA Announce Awards to Advance Regulatory Science
The National Institutes of Health will award $9.4 million over three years to support four research projects in regulatory science. This research is conducted in partnership with the U.S. Food and Drug Administration, which will contribute approximately $950,000. [National Institutes of Health, United States]

Tumor Microenvironment Network (TMEN) (U54) (RFA-CA-10-021) [Department of Health and Human Services, United States]

Resource Related Research Projects for Development of Animal Models and Related Materials (R24) (PAR-10-289) [National Center for Research Resources, United States]

Animal and Biological Material Resource Centers (P40) (PAR-11-001) [National Center for Research Resources, United States]

NHLBI Translational Research Implementation Program (TRIP) – Limited Competition – (P50) (RFA-HL-12-003) [National Heart, Lung, and Blood Institute, United States]

Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-24548) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-24680) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-24549) [National Institutes of Health, United States]




EVENTS (Listed by Date)

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology
November 7-10, 2010
Singapore

2010 Annual Meeting of the American College of Allergy, Asthma & Immunology
November 11-16, 2010
Phoenix, United States

39th Autumn Immunology Conference
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

The 50th Midwinter Conference of Immunologists at Asilomar
January 22-25, 2011
Pacific Grove, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

Phacilitate 9th Annual North American Vaccine Forum
January 24-26, 2011
Washington, DC, United States

Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity joint with Cancer Control by Tumor Suppressors and Immune Effectors
February 12-17, 2011
Santa Fe, United States

Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
February 15-20, 2011
Taos, United States

BMT Tandem Meetings (ASBMT/CIBMTR)
February 17-21, 2011
Honolulu, Hawaii

18th Conference on Retroviruses and Opportunistic Infections (CROI 2011)
February 27-March 2, 2011
Boston, United States

The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting
March 18-22, 2011
San Francisco, United States

Microbiota and Mucosal Immunology: The Interface in Health and Disease
April 14-16, 2011
San Francisco, United States

GTCbio: 2nd International Conference on Cancer Immunotherapy & Immunomonitoring
May 2-5, 2011
Budapest, Hungary

American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-22, 2011
Seattle, United States

Gordon Research Conference: Viruses & Cells
May 29-June 3, 2011
Lucca (Barga), Italy

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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