Volume 2.35 | Sep 17

Immune Regulation News 2.35, September 17, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Oral Tolerance to Food-Induced Systemic Anaphylaxis Mediated by the C-Type Lectin SIGNR1  ShareThis
Researchers propose that a C-type lectin receptor, SIGNR-1 (also called Cd209b), helps to condition dendritic cells in the gastrointestinal lamina propria for the induction of oral tolerance in a model of food-induced anaphylaxis. [Nat Med]

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NYU Langone Scientists Find Key Pathway Implicated in Progression of Childhood Cancer
According to a new study, a protein crucial for the immune response appears to be a key player in the progression of T cell acute lymphoblastic leukemia. [Press release from NYU Langone Medical Center discussing online prepublication in Cancer Cell]

U-M Researchers Examine New Treatment for Type I Diabetes
Using immunology laboratory findings and mathematical models, researchers expect to create a detailed picture of the immune responses leading to the pancreatic cell damage in those considered at risk for developing type I diabetes. [University of Michigan Press Release]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Confinement-Optimized Three-Dimensional T Cell Amoeboid Motility is Modulated via Myosin IIA-Regulated Adhesions
Here, researchers show that in vivo, myosin IIA-deficient T cells had a triad of defects, including overadherence to high-endothelial venules, less interstitial migration and inefficient completion of recirculation through lymph nodes. [Nat Immunol]

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors
Here, researchers have characterized the functions of human monocytes that lack CD14 (CD14dim) and express CD16. CD14dim monocytes were genetically distinct from natural killer cells. [Immunity]

Immunodominant T Cell Responses to Dengue Virus NS3 are Associated with DHF
In this study, researchers set out to study T cell responses across the entire dengue virus proteome and to see whether these were related to disease severity in a cohort of dengue-infected children from Thailand. [Proc Natl Acad Sci USA]

Shared Molecular Amino Acid Signature in the HLA-DR Peptide Binding Pocket Predisposes to Both Autoimmune Diabetes and Thyroiditis
Type IA diabetes (T1D) and autoimmune thyroid disease (AITD) frequently occur together in the same individual, a condition classified as a variant of the autoimmune polyglandular syndrome type 3 (APS3). Because T1D and AITD are individually strongly associated with different HLA class II sequences, researchers asked which HLA class II pocket sequence and structure confer joint susceptibility to both T1D and AITD in the same individual (APS3v). [Proc Natl Acad Sci USA]

Chemotherapy-Induced Genotoxic Stress Promotes Sensitivity to Natural Killer Cell Cytotoxicity by Enabling Missing-Self Recognition
Here, researchers show that Clr-b is rapidly downregulated in cells undergoing genotoxic and cellular stress at the level of both RNA and surface protein. [Cancer Res]

T Cells Expressing Constitutively Active Akt Resist Multiple Tumor-associated Inhibitory Mechanisms
Constitutively active Akt-transduced T cells showed resistance to several evasion strategies employed by tumors and may therefore enhance the antitumor activity of adoptively transferred T lymphocytes. [Mol Ther]

Combined Administration of a Mutant TGF-Beta1/Fc and Rapamycin Promotes Induction of Regulatory T Cells and Islet Allograft Tolerance
In this study, researchers report the development of a long-lasting autoactive human mutant TGF-beta1/Fc fusion protein that acts in conjunction with rapamycin to inhibit T cell proliferation and induce the de novo generation of Foxp3+ regulatory T cell in the periphery, while at the same time inhibiting IL-6-mediated Th17 cell differentiation. [J Immunol]

TLR Agonists that Induce IFN-Beta Abrogate Resident Macrophage Suppression of T Cells
The results suggest TLR agonists that activate TRIF, and consequently induce IFN-beta, but not those that exclusively signal through MyD88, abrogate the immunosuppressive properties of resident tissue macrophages, and thus promote T cell expansion and elimination of invading microorganisms. [J Immunol]


Maryland Stem Cell Research Commission to Host Third Annual Maryland Stem Cell Research Symposium
The Maryland Stem Cell Research Commission will host the Third Annual Maryland Stem Cell Research Symposium in partnership with the National Institutes of Health and the National Institute of Standards and Technology on Sept. 22, 2010. [The Maryland Stem Cell Research Commission Press Release]

Inovio Pharmaceuticals Achieves Unprecedented T Cell Immune Responses in Human Trial of DNA Vaccine for Cervical Dysplasia and Cancer Caused by HPV
Inovio Pharmaceuticals, Inc. announced that it has achieved best-in-class immune responses in its Phase I dose escalation study of VGX-3100, its DNA vaccine to treat pre-cancerous cervical dysplasias and cervical cancers caused by human papillomavirus (HPV) types 16 and 18. [Inovio Pharmaceuticals, Inc. Press Release]

Scott & White Healthcare – Round Rock to Participate in International Clinical Trial Investigating Lung Cancer Treatment
Scott & White Healthcare is recruiting patients for a Phase III lung cancer trial aimed at preventing the disease’s recurrence in previously treated patients. The trial will evaluate the potential of an immunotherapy called Antigen-Specific Cancer Immunotherapeutic for the treatment of Non-Small Cell Lung Cancer. [Scott & White Healthcare Press Release]


NIH Expands Network Focused on How Genes Affect Drug Responses [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-22327) [National Institutes of Health, United States]

National Center for Research Resources; Notice of Closed Meetings (FR Doc. 2010-22529) [National Institutes of Health, United States]

Notice of Correction:  Application Due Date for RFA-HG-10-012, Revolutionary Genome Sequencing Technologies – The $1000 Genome (R01) and RFA-HG-10-013, Revolutionary Genome Sequencing Technologies – The $1000 Genome (R21) (Notice Number:NOT-HG-10-021) [National Institutes of Health, United States]

Knockout Mouse Production and Cryopreservation (U42) (RFA-RM-10-013) [National Institutes of Health, United States]

Knockout Mouse Phenotyping Project Database (U54) (RFA-RM-10-012) [National Institutes of Health, United States]

Knockout Mouse Phenotyping (U54) (RFA-RM-10-011) [National Institutes of Health, United States]

Enhancing Peer Review:  Reminder of and Correction to Previous Notice on A2 Resubmission Opportunities for Eligible Applications (NOT-OD-10-135) [National Institutes of Health, United States]

Notice of Correction to RFA-AG-11-010, Basic Research on Self-Regulation (R21) (NOT-AG-10-011) [National Institutes of Health, United States]

Agenda for the Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations [Food and Drug Administration, United States]

EVENTS (Listed by Date)

Immunology & Microbiology, Genetics & Genomics, Development, Other
September 18-22, 2010
Barcelona, Spain

Cell Symposia: Inflammation and Disease
September 26-28, 2010
Lisbon, Portugal

11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology – DC2010: Forum on Vaccine Science
September 26-30, 2010
Lugano, Switzerland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

Phacilitate’s 7th Annual Cell & Gene Therapy Forum
January 24-26, 2011
Washington DC, United States

Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity joint with Cancer Control by Tumor Suppressors and Immune Effectors
February 12-17, 2011
Santa Fe, United States

Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
February 15-20, 2011
Taos, United States

The 6th International Conference on Oncolytic Viruses As Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

NEW Microbiota and Mucosal Immunology: The Interface in Health and Disease
April 14-16, 2011
San Francisco, United States

American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-22, 2011
Seattle, United States

Gordon Research Conferences: Viruses & Cells
May 29-June 3, 2011
Lucca, Italy

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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