Volume 2.34 | Sep 10

Immune Regulation News 2.34, September 10, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


TOP STORY

Novel Sensing Mechanism Discovered in Dendritic Cells to Increase Immune Response to HIV
A team of scientists has discovered a sensor in dendritic cells that recognizes HIV, spurring a more potent immune response by the sentinels to the virus. [Press release from the NYU Langone Medical Center discussing online prepublication in NatureShareThis

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SCIENCE NEWS

Scientists Identify Molecular Gatekeeper of Arthritis
Elimination of a molecular gatekeeper leads to the development of arthritis in mice, scientists report. [Press release from the University of Rochester Medical Center discussing online prepublication in The Journal of Experimental Medicine]

Microfluidic Device Allows Collection, Analysis of Hard-to-Handle Immune Cells
Researchers have developed a new microfluidic tool for quickly and accurately isolating neutrophils from small blood samples, an accomplishment that could provide information essential to better understanding the immune system’s response to traumatic injury. [Press release from Massachusetts General Hospital discussing online prepublication in Nature Medicine]

Investigating Better Endpoints for Immunotherapy Trials
Cancer immunotherapy calls for revised clinical endpoints that differ from those used for chemotherapy, according to an article. [Press release from EurekAlert! discussing online prepublication in The Journal of the National Cancer Institute]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Oligomeric Organization of the B Cell Antigen Receptor on Resting Cells
Researchers propose that oligomers are the autoinhibited form of the B cell antigen receptor (BCR) and that it is the shift from closed BCR oligomers to clustered monomers that drives B cell activation in a way that is independent of the structural input from the antigen. [Nature]

A Cryptic Sensor for HIV-1 Activates Antiviral Innate Immunity in Dendritic Cells
Here, researchers show that when dendritic cell resistance to infection is circumvented, HIV-1 induces dendritic cell maturation, an antiviral type I interferon response and activation of T cells. [Nature]

Clinical Microfluidics for Neutrophil Genomics and Proteomics
Researchers present a robust methodology for rapidly isolating neutrophils directly from whole blood with ‘on-chip’ processing for mRNA and protein isolation for genomics and proteomics. [Nat Med]

The Transcription Cofactor Hopx is Required for Regulatory T Cell Function in Dendritic Cell-Mediated Peripheral T Cell Unresponsiveness
Researchers report a critical role for the transcription cofactor homeodomain-only protein (Hop; also known as Hopx) in induced regulatory T cells to mediate T cell unresponsiveness in vivo. [Nat Immunol]

Gamma-Delta T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism
Using IL-23R reporter mice, researchers showed that gamma-delta T cells were the first cells to respond to IL-23 during experimental autoimmune encephalomyelitis. [Immunity]

G(Alphaq)-Containing G Proteins Regulate B Cell Selection and Survival and are Required to Prevent B Cell-Dependent Autoimmunity
The data show for the first time that signaling through trimeric G proteins is critically important for maintaining control of peripheral B cell tolerance induction and repressing autoimmunity. [J Exp Med]

Antibody Targeting KIT as Pre-Transplant Conditioning in Immunocompetent Mice
Researchers studied the efficacy of administering a novel sequential treatment of parenteral ACK2, an antibody that blocks KIT, followed by low-dose irradiation for conditioning of wild-type and X-linked chronic granulomatous disease mice. [Blood]

Notch Signaling Contributes to Proliferation and Tumor Formation of Human T Cell Leukemia Virus Type 1-Associated Adult T Cell Leukemia
In this study, researchers report a high frequency of constitutively activated Notch in adult T cell leukemia patients. [Proc Natl Acad Sci USA]


INDUSTRY NEWS

STEMSOFT® Software Inc. Licenses StemLab® Software to Arizona’s Celebration Stem Cell Centre
STEMSOFT Software Inc., the leading provider of software solutions for the cell therapy and transplant community, is pleased to announce the licensing of StemLab, the leading cell therapy and cord blood banking laboratory software, to the Celebration Stem Cell Centre in Gilbert, Arizona. [STEMSOFT Software Inc. Press Release]

Stellar Biotechnologies Files Key Patent for Company
Stellar Biotechnologies, Inc. announces filing for patent protection of inventions related to its native Immunogenic (IMG) KLH technology platform and immune status monitoring product portfolio. [Stellar Biotechnologies, Inc. Press Release]

ImmunoCellular Therapeutics Announces Long-Term Disease-Free Survival Data from Phase I Study in Glioblastoma
ImmunoCellular Therapeutics, Ltd., a biotechnology company focused on the development of novel immune-based cancer therapies, announced long-term data from a Phase I clinical trial of ICT-107, the Company’s lead cancer vaccine candidate for the treatment of glioblastoma multiforme (GBM), the most common and aggressive form of brain cancer. [ImmunoCellular Therapeutics, Ltd. Press Release]


POLICY NEWS

Notice of Meeting: Secretary’s Advisory Committee on Genetics, Health, and Society (FR Doc. 2010-21532) [Department of Health and Human Services, United States]

Findings of Research Misconduct (NOT-OD-10-132) [Department of Health and Human Services, United States]

Protein Structure Initiative:Biology-Materials Repository (PSI:Biology-MR) (U01) (RFA-GM-11-008) [National Institute of General Medical Sciences, United States]

Developing and Improving Institutional Animal Resources (G20) (RFA-RR-10-011) [National Center for Research Resources, United States]

Clarification on the Roles of NIH Scientific Review Groups (SRG) and Institutional Animal Care and Use Committees (IACUC) in Review of Vertebrate Animal Research (NOT-OD-10-128) [National Institutes of Health, United States]

Clarification of Eligible Institutions for PA-10-050: Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-21816) [National Institutes of Health, United States]


EVENTS (Listed by Date)

Select Biosciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

Immunology & Microbiology, Genetics & Genomics, Development, Other
September 18-22, 2010
Barcelona, Spain

Cell Symposia: Inflammation and Disease
September 26-28, 2010
Lisbon, Portugal

11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology – DC2010: Forum on Vaccine Science
September 26-30, 2010
Lugano, Switzerland

5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece

Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States

Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States

New! Phacilitate’s 7th Annual Cell & Gene Therapy Forum
January 24-26, 2011
Washington DC, United States

New! Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity joint with Cancer Control by Tumor Suppressors and Immune Effectors
February 12-17, 2011
Santa Fe, United States

New! Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
February 15-20, 2011
Taos, United States

New! The 6th International Conference on Oncolytic Viruses As Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States

New! American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-22, 2011
Seattle, United States

New! Gordon Research Conferences: Viruses & Cells
May 29-June 3, 2011
Lucca, Italy

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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